|
|
 Previous Article | Table of Contents | Next Article 
Expression and release of CD27 in human B-cell malignancies
MH van Oers, ST Pals, LM Evers, CE van der Schoot, G Koopman, JM Bonfrer, RQ Hintzen, AE von dem Borne and RA van Lier
Department of Hematology, Academic Medical Center, Amsterdam, The
Netherlands.
CD27, a transmembrane disulfide-linked 55-kD homodimer, belongs to the
nerve growth factor-receptor family, a group of homologous molecules
involved in lymphocyte differentiation and selection. It is expressed on
mature thymocytes, peripheral blood T cells, and a subpopulation of B
cells. We investigated the expression of CD27 on malignant B cells
representative for a broad range of stages in physiologic antigen-
independent and -dependent B-cell development. In normal lymphoid tissue
CD27+ B cells were only found in the peripheral blood (29.8% +/- 10.8%, n =
13) and in germinal centers. With the exception of pro-B and the majority
of pre-pre-B acute lymphocytic leukemias and of myelomas, CD27 expression
of variable intensity was detected on almost all immature and mature
malignant B cells tested. Moreover, using a sandwich enzyme-linked
immunosorbent assay we could show the presence of sometimes very high (up
to 6,000 U/mL; normal values < 190 U/mL) amounts of the soluble 28- to
32-kD form of CD27 (sCD27) in the sera of patients with B-cell
malignancies. The highest levels of sCD27 were observed in patients with
chronic lymphocytic leukemia and low-grade non-Hodgkin's lymphomas. Most
importantly, both in transversal and longitudinal studies, we found a
strong correlation between sCD27 levels in the serum and tumor load,
indicating that sCD27 can be used as a disease-marker in patients with
acute and chronic B-cell malignancies.
Volume 82,
Issue 11,
pp. 3430-3436,
12/01/1993
Copyright © 1993 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. W. Ho, E. Hatjiharissi, B. T. Ciccarelli, A. R. Branagan, Z. R. Hunter, X. Leleu, O. Tournilhac, L. Xu, K. O'Connor, R. J. Manning, et al.
CD27-CD70 interactions in the pathogenesis of Waldenstrom macroglobulinemia
Blood,
December 1, 2008;
112(12):
4683 - 4689.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Mondria, C H J Lamers, P A W t. Boekhorst, J W Gratama, and R Q Hintzen
Bone-marrow transplantation fails to halt intrathecal lymphocyte activation in multiple sclerosis
J. Neurol. Neurosurg. Psychiatry,
September 1, 2008;
79(9):
1013 - 1015.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Bleesing, M. M. Souto-Carneiro, W. J. Savage, M. R. Brown, C. Martinez, S. Yavuz, S. Brenner, R. M. Siegel, M. E. Horwitz, P. E. Lipsky, et al.
Patients with Chronic Granulomatous Disease Have a Reduced Peripheral Blood Memory B Cell Compartment.
J. Immunol.,
June 1, 2006;
176(11):
7096 - 7103.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Xiao, J. Hendriks, P. Langerak, H. Jacobs, and J. Borst
CD27 Is Acquired by Primed B Cells at the Centroblast Stage and Promotes Germinal Center Formation
J. Immunol.,
June 15, 2004;
172(12):
7432 - 7441.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Marafioti, M. Jones, F. Facchetti, T. C. Diss, M.-Q. Du, P. G. Isaacson, M. Pozzobon, S. A. Pileri, A. J. Strickson, S.-Y. Tan, et al.
Phenotype and genotype of interfollicular large B cells, a subpopulation of lymphocytes often with dendritic morphology
Blood,
October 15, 2003;
102(8):
2868 - 2876.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ek, C.-M. Hogerkorp, M. Dictor, M. Ehinger, and C. A. K. Borrebaeck
Mantle Cell Lymphomas Express a Distinct Genetic Signature Affecting Lymphocyte Trafficking and Growth Regulation as Compared with Subpopulations of Normal Human B Cells
Cancer Res.,
August 1, 2002;
62(15):
4398 - 4405.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. N. Damle, F. Ghiotto, A. Valetto, E. Albesiano, F. Fais, X.-J. Yan, C. P. Sison, S. L. Allen, J. Kolitz, P. Schulman, et al.
B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes
Blood,
May 13, 2002;
99(11):
4087 - 4093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wischhusen, G. Jung, I. Radovanovic, C. Beier, J. P. Steinbach, A. Rimner, H. Huang, J. B. Schulz, H. Ohgaki, A. Aguzzi, et al.
Identification of CD70-mediated Apoptosis of Immune Effector Cells as a Novel Immune Escape Pathway of Human Glioblastoma
Cancer Res.,
May 1, 2002;
62(9):
2592 - 2599.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. E. P. Dekkers, T. ten Hove, F. N. Lauw, H. R. Koene, P. Lumley, S. J. H. van Deventer, and T. van der Poll
The Metalloproteinase Inhibitor GI5402 Inhibits Endotoxin-Induced Soluble CD27 and CD16 Release in Healthy Humans
Infect. Immun.,
May 1, 2000;
68(5):
3036 - 3039.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Nagumo, K. Agematsu, K. Shinozaki, S. Hokibara, S. Ito, M. Takamoto, T. Nikaido, K. Yasui, Y. Uehara, A. Yachie, et al.
CD27/CD70 Interaction Augments IgE Secretion by Promoting the Differentiation of Memory B Cells into Plasma Cells
J. Immunol.,
December 15, 1998;
161(12):
6496 - 6502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. G. Tangye, Y.-J. Liu, G. Aversa, J. H. Phillips, and J. E. de Vries
Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27
J. Exp. Med.,
November 2, 1998;
188(9):
1691 - 1703.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Agematsu, H. Nagumo, Y. Oguchi, T. Nakazawa, K. Fukushima, K. Yasui, S. Ito, T. Kobata, C. Morimoto, and A. Komiyama
Generation of Plasma Cells From Peripheral Blood Memory B Cells: Synergistic Effect of Interleukin-10 and CD27/CD70 Interaction
Blood,
January 1, 1998;
91(1):
173 - 180.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. V. S. Prasad, Z. Ao, Y. Yoon, M. X. Wu, M. Rizk, S. Jacquot, and S. F. Schlossman
CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein
PNAS,
June 10, 1997;
94(12):
6346 - 6351.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
