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Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity
induces K562 to differentiate
M Anafi, A Gazit, A Zehavi, Y Ben-Neriah and A Levitzki
Lautenberg Center for Immunology, Hebrew University Hadassah Medical
School, Jerusalem, Israel.
We report on the potency of two Tyrphostin tyrosine kinase blockers, AG
1112 and AG 568, to inhibit p210bcr-abl tyrosine kinase activity in K562
cells, concomitant with the induction of erythroid differentiation. AG 568
and especially AG 1112 represent a specific group of nontoxic protein
tyrosine kinase blockers among more than 1,400 tested. These compounds
possess therapeutic potential for purging Philadelphia chromosome-positive
cells in preparation for autologous bone marrow transplantation in chronic
myelogenous leukemia.
Volume 82,
Issue 12,
pp. 3524-3529,
12/15/1993
Copyright © 1993 by The American Society of Hematology
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