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Cross-linking of the beta-glucan receptor on human monocytes results in
interleukin-1 receptor antagonist but not interleukin-1 production
DD Poutsiaka, M Mengozzi, E Vannier, B Sinha and CA Dinarello
Department of Medicine, New England Medical Center, Boston, MA 02111.
The beta-glucan receptor, found on monocytes and neutrophils, binds glucose
polymers derived from fungi. Ligands for the receptor have various
immunomodulatory effects, including increased microbicidal killing
activity. We have investigated the effect of beta-glucans on the production
of interleukin-1 (IL-1) and its naturally occurring inhibitor, the IL-1
receptor antagonist (IL-1Ra). Particulate beta- glucan induced IL-1Ra
production from human peripheral blood mononuclear cells (PBMC) but did not
stimulate IL-1 beta synthesis or gene expression in these same cells.
Monomeric (soluble) beta-glucan did not induce IL-1Ra production. However,
when preincubated with PBMC, monomeric beta-glucan significantly (P <
.01) reduced particulate beta- glucan induction of IL-1Ra by 40%,
suggesting that crosslinking of beta- glucan receptors is required for
induction of IL-1Ra. In support of this, monomeric beta-glucan immobilized
on plastic surfaces stimulated IL-1Ra production. Vitamin D3, which
increases the functional capacity of beta-glucan receptors, increased
IL-1Ra production induced by particulate beta-glucan, whereas dexamethasone
suppressed IL-1Ra synthesis. Because of their differential effects on
cytokine production, beta-glucans may be used to therapeutic advantage in
the diseases in which IL-1 is implicated.
Volume 82,
Issue 12,
pp. 3695-3700,
12/15/1993
Copyright © 1993 by The American Society of Hematology
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