|
|
 Previous Article | Table of Contents | Next Article 
Aspirin does not inhibit adenosine diphosphate-induced platelet alpha-
granule release
CS Rinder, LA Student, JL Bonan, HM Rinder and BR Smith
Department of Anesthesiology, Yale University School of Medicine, New
Haven, CT 06510.
The involvement of metabolites of arachidonic acid in platelet-dense
granule secretion and secondary platelet-platelet interactions is well
characterized. However, their role in heterotypic interactions dependent on
alpha-granule secretion is less well understood. Using platelet-surface
expression of P-selectin as a marker of alpha-granule secretion, we have
shown that: (1) aspirin treatment of platelets at doses that block dense
granule secretion does not inhibit alpha-granule secretion to adenosine
diphosphate (ADP); (2) synergism between epinephrine and ADP in the
induction of P-selectin expression is similarly unaffected by aspirin; and
(3) the ability of P-selectin to mediate adhesion of activated platelets to
monocytes and polymorphonuclear lymphocytes in whole blood is also
unchanged by aspirin treatment. To further explore the mechanisms
responsible for platelet alpha-granule secretion, we have shown that
inhibition of Na+/H+ exchange by either acidification of the extracellular
medium or amiloride treatment blocked ADP-induced P-selectin expression. In
contrast, incubation with the platelet lipoxygenase inhibitor 5,8,11-
eicosatrynoic acid, by itself and with aspirin, did not decrease ADP-
induced P-selectin expression. We conclude that platelet alpha-granule
secretion in response to ADP is dependent on intact Na+/H+ exchange but is
independent of the lipoxygenase- and cyclooxygenase-dependent metabolites
of arachidonic acid.
Volume 82,
Issue 2,
pp. 505-512,
07/15/1993
Copyright © 1993 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Eligini, S. S. Barbieri, I. Arenaz, E. Tremoli, and S. Colli
Paracrine up-regulation of monocyte cyclooxygenase-2 by platelets: Role of transforming growth factor-{beta}1
Cardiovasc Res,
May 1, 2007;
74(2):
270 - 278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Borgdorff, G. J. Tangelder, and W. J. Paulus
Cyclooxygenase-2 Inhibitors Enhance Shear Stress-Induced Platelet Aggregation
J. Am. Coll. Cardiol.,
August 15, 2006;
48(4):
817 - 823.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Borgdorff and G. J. Tangelder
Pump-induced platelet aggregation with subsequent hypotension: Its mechanism and prevention with clopidogrel
J. Thorac. Cardiovasc. Surg.,
April 1, 2006;
131(4):
813 - 821.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Connolly, A. Choudhury, R. C. Davis, and G. Y. H. Lip
A randomized trial of aspirin on the risk of embolic events in patients with infective endocarditis
J. Am. Coll. Cardiol.,
March 17, 2004;
43(6):
1134 - 1135.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Silverman, T. Halaszynski, R. Sinatra, M. Luther, and C. S. Rinder
Rofecoxib does not compromise platelet aggregation during anesthesia and surgery: [Le rofecoxib n'altere pas l'agregation plaquettaire pendant l'anesthesie et la chirurgie]
Can J Anesth,
December 1, 2003;
50(10):
1004 - 1008.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yamazaki, S. Uchiyama, A. J. Grau, L. Marquardt, and A. Ruf
Platelet Function Under Aspirin, Clopidogrel, and Both After Ischemic Stroke: A Case-Crossover Study * Response
Stroke,
December 1, 2003;
34
(12):
e227 - e228.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Nishimura, T. Hashimoto, H. Kobayashi, T. Fukuda, K. Okino, N. Yamamoto, N. Iwamoto, N. Nakamura, T. Yoshikawa, and T. Ono
The high incidence of left atrial appendage thrombosis in patients on maintenance haemodialysis
Nephrol. Dial. Transplant.,
November 1, 2003;
18(11):
2339 - 2347.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Valles, M. T. Santos, J. Aznar, M. Martinez, A. Moscardo, M. Pinon, M. J. Broekman, and A. J. Marcus
Platelet-erythrocyte interactions enhance alpha IIbbeta 3 integrin receptor activation and P-selectin expression during platelet recruitment: down-regulation by aspirin ex vivo
Blood,
May 13, 2002;
99(11):
3978 - 3984.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kamath, A. D. Blann, G. J. Caine, D. Gurney, B. S.P. Chin, and G. Y.H. Lip
Platelet P-Selectin Levels in Relation to Plasma Soluble P-Selectin and {beta}-Thromboglobulin Levels in Atrial Fibrillation
Stroke,
May 1, 2002;
33(5):
1237 - 1242.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Graff, U. Klinkhardt, V. B. Schini-Kerth, S. Harder, N. Franz, S. Bassus, and C. M. Kirchmaier
Close Relationship between the Platelet Activation Marker CD62 and the Granular Release of Platelet-Derived Growth Factor
J. Pharmacol. Exp. Ther.,
March 1, 2002;
300(3):
952 - 957.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Li, N. H. Wallen, and P. Hjemdahl
Evidence for Prothrombotic Effects of Exercise and Limited Protection by Aspirin
Circulation,
September 28, 1999;
100(13):
1374 - 1379.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K Nakamura, H Kariyazono, T Shinkawal, T Yamaguchi, T Yamashita, O Ayukawal, Y Moriyama, G Yotsumoto, H Toyohira, A Taira, et al.
Inhibitory effects of H2-receptor antagonists on platelet function in vitro
Human and Experimental Toxicology,
August 1, 1999;
18(8):
487 - 492.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. Z. Naqvi, P. K. Shah, P. A. Ivey, M. D. Molloy, P. Linn, M. Linker-Israeli, B. Cercek, and S. Kaul
Therapeutic Concentrations of Heparin Augment Platelet Activation at the Time of Coronary Angiography
Journal of Cardiovascular Pharmacology and Therapeutics,
January 1, 1998;
3(2):
91 - 101.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. J. Knight, M. Panesar, C. Wright, D. Clarke, P. S. Butowski, D. Patel, A. Patrineli, K. Fox, and A. H. Goodall
Altered Platelet Function Detected by Flow Cytometry : Effects of Coronary Artery Disease and Age
Arterioscler. Thromb. Vasc. Biol.,
October 1, 1997;
17(10):
2044 - 2053.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y. Merhi, P. Provost, R. Guidoin, and J.-G. Latour
Importance of Platelets in Neutrophil Adhesion and Vasoconstriction After Deep Carotid Arterial Injury by Angioplasty in Pigs
Arterioscler. Thromb. Vasc. Biol.,
June 1, 1997;
17(6):
1185 - 1191.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Humbert, P. Nurden, C. Bihour, J.-M. Pasquet, J. Winckler, E. Heilmann, P. Savi, J.-M. Herbert, T. J. Kunicki, and A. T. Nurden
Ultrastructural Studies of Platelet Aggregates From Human Subjects Receiving Clopidogrel and From a Patient With an Inherited Defect of an ADP-Dependent Pathway of Platelet Activation
Arterioscler. Thromb. Vasc. Biol.,
December 1, 1996;
16(12):
1532 - 1543.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
E.J. Langford, R.J. Wainwright, and J.F. Martin
Platelet Activation in Acute Myocardial Infarction and Unstable Angina Is Inhibited by Nitric Oxide Donors
Arterioscler. Thromb. Vasc. Biol.,
January 1, 1996;
16(1):
51 - 55.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Lopez-Farre, C. Caramelo, A. Esteban, M. L. Alberola, I. Millas, M. Monton, and S. Casado
Effects of Aspirin on Platelet-Neutrophil Interactions : Role of Nitric Oxide and Endothelin-1
Circulation,
April 1, 1995;
91(7):
2080 - 2088.
[Abstract]
[Full Text]
|
|
|
|
|
