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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cermak, J. Articles by Vercellotti, G. M. Search for Related Content PubMed PubMed Citation Articles by Cermak, J. Articles by Vercellotti, G. M. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor J Cermak, NS Key, RR Bach, J Balla, HS Jacob and GM Vercellotti Department of Medicine, University of Minnesota, Minneapolis 55455. The acute inflammatory response is frequently accompanied by serious thrombotic events. We show that C-reactive protein (CRP), an acute- phase reactant that markedly increases its serum concentration in response to inflammatory stimuli, induced monocytes to express tissue factor (TF), a potent procoagulant. Purified human CRP in concentrations commonly achieved in vivo during inflammation (10 to 100 micrograms/mL) induced a 75-fold increase in TF procoagulant activity (PCA) of human peripheral blood mononuclear cells (PBM), with a parallel increase in TF antigen levels. CRP-induced PCA was completely blocked by a monoclonal antibody against human TF but not by irrelevant murine IgG. Dot blot analysis showed a significant increase of TF mRNA after 4 hours of incubation with CRP, followed by a peak of PCA within 6 and 8 hours. Actinomycin D and cycloheximide blocked CRP-stimulated PCA, suggesting that de novo TF protein synthesis was required. Endotoxin (LPS) contamination of CRP was excluded as the mediator of TF synthesis because: (1) CRP was Limulus assay negative; (2) induction of TF PCA by CRP was not blocked by Polymyxin B, in contrast to LPS- induced PCA; (3) antihuman CRP IgG inhibited CRP-induced PCA, but not LPS-induced PCA; (4) CRP was able to stimulate TF production in LPS- pretreated PBM refractory to additional LPS stimulation; and, (5) unlike LPS, CRP was incapable of inducing TF in human umbilical vein endothelial cells. We suggest that CRP-mediated TF production in monocytes may contribute to the development of disseminated intravascular coagulation and thrombosis in inflammatory states. Volume 82, Issue 2, pp. 513-520, 07/15/1993 Copyright © 1993 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. M. McDermott and D. M. 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Yamamoto The Coagulation-Fibrinolysis System in Patients With Leukoaraiosis and Binswanger Disease Arch Neurol, October 1, 2001; 58(10): 1620 - 1625. [Abstract] [Full Text] [PDF] D. M. Herrington, K. B. Brosnihan, B. E. Pusser, E. W. Seely, P. M. Ridker, N. Rifai, and D. B. MacLean Differential Effects of E and Droloxifene on C-Reactive Protein and Other Markers of Inflammation in Healthy Postmenopausal Women J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4216 - 4222. [Abstract] [Full Text] [PDF] J. C. Chambers, S. Eda, P. Bassett, Y. Karim, S. G. Thompson, J. R. Gallimore, M. B. Pepys, and J. S. Kooner C-Reactive Protein, Insulin Resistance, Central Obesity, and Coronary Heart Disease Risk in Indian Asians From the United Kingdom Compared With European Whites Circulation, July 10, 2001; 104(2): 145 - 150. [Abstract] [Full Text] [PDF] M. Feldman, I. Jialal, S. Devaraj, and B. Cryer Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2 concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assay J. Am. Coll. Cardiol., June 15, 2001; 37(8): 2036 - 2041. [Abstract] [Full Text] [PDF] R. P. Tracy Is Visceral Adiposity the "Enemy Within"? Arterioscler Thromb Vasc Biol, June 1, 2001; 21(6): 881 - 883. [Full Text] [PDF] I. Lemieux, A. Pascot, D. Prud'homme, N. Almeras, P. Bogaty, A. Nadeau, J. Bergeron, and J.-P. Despres Elevated C-Reactive Protein : Another Component of the Atherothrombotic Profile of Abdominal Obesity Arterioscler Thromb Vasc Biol, June 1, 2001; 21(6): 961 - 967. [Abstract] [Full Text] [PDF] V. Pasceri, J. Chang, J. T. Willerson, and E. T. H. Yeh Modulation of C-Reactive Protein-Mediated Monocyte Chemoattractant Protein-1 Induction in Human Endothelial Cells by Anti-Atherosclerosis Drugs Circulation, May 29, 2001; 103(21): 2531 - 2534. [Abstract] [Full Text] [PDF] G. Liuzzo, D. J. Angiolillo, A. Buffon, V. Rizzello, C. Colizzi, F. Ginnetti, L. M. Biasucci, and A. Maseri Enhanced Response of Blood Monocytes to In Vitro Lipopolysaccharide-Challenge in Patients With Recurrent Unstable Angina Circulation, May 8, 2001; 103(18): 2236 - 2241. [Abstract] [Full Text] [PDF] M. H. A. M. Veltrop, J. A. M. Langermans, J. Thompson, and M. J. L. M. F. Bancsi Interleukin-10 Regulates the Tissue Factor Activity of Monocytes in an In Vitro Model of Bacterial Endocarditis Infect. Immun., May 1, 2001; 69(5): 3197 - 3202. [Abstract] [Full Text] [PDF] K. A. HERZIG, D. M. PURDIE, W. CHANG, A. M. BROWN, C. M. HAWLEY, S. B. CAMPBELL, J. M. STURTEVANT, N. M. ISBEL, D. L. NICOL, and D. W. JOHNSON Is C-Reactive Protein a Useful Predictor of Outcome in Peritoneal Dialysis Patients? J. Am. Soc. Nephrol., April 1, 2001; 12(4): 814 - 821. [Abstract] [Full Text] [PDF]

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