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ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of
early infancy
G Cimino, F Lo Coco, A Biondi, L Elia, A Luciano, CM Croce, G Masera, F Mandelli and E Canaani
Department of Hematology, University La Sapienza of Rome, Italy.
Early infancy (< 1 year of age), massive tumor cell burden, and
extremely poor prognosis are characteristic features of a particular subset
of childhood acute leukemias (AL). In these cases, chromosome aberrations
at the 11q23 band are the most frequently reported cytogenetic
abnormalities. We have recently cloned a genetic locus named ALL-1, in
which DNA breakpoints are clustered in leukemic patients with 11q23
aberrations. Analysis of the ALL-1 genomic configuration in DNA from 15
infants with AL showed specific ALL-1 rearrangements in 12 cases (80%),
including 5 with normal karyotypes. These findings indicate that a
consistent genetic defect underlies this particular leukemic subset.
Volume 82,
Issue 2,
pp. 544-546,
07/15/1993
Copyright © 1993 by The American Society of Hematology
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