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Heterogeneity of breakpoints of 11q23 rearrangements in hematologic
malignancies identified with fluorescence in situ hybridization
H Kobayashi, R Espinosa , MJ Thirman, HJ Gill, AA Fernald, MO Diaz, MM Le Beau and JD Rowley
Department of Medicine, University of Chicago, IL 60637.
Twenty-four patients whose cells contained a variety of 11q23
rearrangements, including translocations, insertions, and an inversion,
were studied using fluorescence in situ hybridization with cosmid, phage,
and plasmid probes mapped to 11q22-24. In 17 patients, the breakpoints of
the common 11q23 translocations involving chromosomes 4, 6, 9, and 19 as
well as some uncommon translocations involving 3q23, 17q25, 10p11, and an
insertion 10;11 were all located in the breakpoint cluster region of the
MLL gene, regardless of age, phenotype of disease, or involvement of a
third chromosome. The breakpoints in 11q23 in the other 7 patients with a
t(7;11)(p15;q23), inv(11)(p11q23), t(4;11)(q23;q23),
der(5)t(5;11)(q13;q23), ins(10;11)(p11;q23q24), t(11;14)(q23;q11), or
t(11;18;11) (p15;q21;q23) were located either centromeric to CD3D or
telomeric to THY1. Thus, although most 11q23 rearrangements, involve the
same breakpoint cluster region of MLL, there is heterogeneity in the
breakpoint in some of the rare rearrangements.
Volume 82,
Issue 2,
pp. 547-551,
07/15/1993
Copyright © 1993 by The American Society of Hematology
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