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Variable morphology of human immunodeficiency virus-associated lymphomas
with c-myc rearrangements. The French Study Group of Pathology for Human
Immunodeficiency Virus-Associated Tumors, I
HJ Delecluse, M Raphael, JP Magaud, P Felman, IA Alsamad, GW Bornkamm and GM Lenoir
Centre International de Recherche sur le cancer, Lyon, France.
Burkitt lymphoma (BL) and immunoblastic lymphoma (IL) are the most frequent
lymphoid tumors encountered in human immunodeficiency virus (HIV)-infected
patients. Tumors with a morphology intermediate between BL and IL, and the
existence of Burkitt's type translocations in some IL cases makes the
classification of these tumors sometimes unclear. We have studied 14 cases
of BL and IL in HIV-seropositive individuals with regard to clonality,
Epstein-Barr virus (EBV) association, and the presence of c-myc
rearrangement. Of seven tumors with morphology of BL, all were monoclonal,
six showed a c-myc rearrangement and four were associated with EBV. Five
tumors with morphology of IL were associated with EBV and devoid of c-myc
rearrangement. Three were polyclonal representing EBV-driven
lymphoproliferations similar to those observed in transplant recipients.
Two tumors, one with a morphology of IL and the other intermediate between
IL and BL were monoclonal, associated with EBV, and harbored a c-myc
rearrangement. We propose that these last two tumors represent cases of BL
that have adopted an immunoblastic morphotype in the context of acquired
immunodeficiency syndrome (AIDS), reflecting the morphologic evolution of
Burkitt lymphoma cells observed in culture.
Volume 82,
Issue 2,
pp. 552-563,
07/15/1993
Copyright © 1993 by The American Society of Hematology
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