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Association of the subtype 2 of the Epstein-Barr virus with T-cell non-
Hodgkin's lymphoma of the midline granuloma type [see comments]
B Borisch, I Hennig, RH Laeng, ER Waelti, R Kraft and J Laissue
Institute of Pathology, University of Berne, Switzerland.
Lethal midline granuloma (LMG) is associated with Epstein-Barr virus (EBV).
The latter has at least two subtypes with different biological properties.
The subtypes can be identified by their genomic configuration. Using
EBV-RNA (EBER) in situ hybridization and EBV polymerase chain reaction
(PCR), we have looked for the presence of EBV in six LMGs and six
non-Hodgkin's lymphomas (NHLs) located in the nasopharyngeal region, and
determined the subtype of EBV. Six of six LMGs were positive by PCR and
EBER in situ hybridization, whereas NHLs were either negative or, in three
of six cases, showed few EBER- positive cells considered to be
nonneoplastic lymphocytes. The subtype 2 was found in LMG lesions of three
of six patients; the remaining three of six patients with LMG had the
generally occurring subtype 1. The results indicate that the association of
EBV with NHL may depend more on tumor type than on its localization. The
occurrence of the rare subtype 2 in LMG may relate to a covert immune
defect.
Volume 82,
Issue 3,
pp. 858-864,
08/01/1993
Copyright © 1993 by The American Society of Hematology
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