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Expression of the c-mpl proto-oncogene in human hematologic malignancies
I Vigon, F Dreyfus, J Melle, F Viguie, V Ribrag, L Cocault, M Souyri and S Gisselbrecht
U363 INSERM, ICGM, Paris, France.
Similar to two other hematopoietic growth factor receptors, the c-fms
(macrophage colony-stimulating factor receptor) and the c-kit genes, c- mpl
has been discovered through the study of oncogenic retroviruses. Unlike
c-fms and c-kit, which both belong to a subgroup of tyrosine kinase
receptors, the c-mpl proto-oncogene encodes a new member of the cytokine
receptor superfamily. We have studied the expression of c-mpl in a series
of 105 patients with hematologic malignancies using Northern blot analysis.
The levels of c-mpl transcripts in lymphoid malignancies and in chronic
myeloproliferative disorders were not significantly different from those
found in normal bone marrow cells, in which c-mpl was barely detectable. In
contrast, c-mpl expression was increased in 26 of 51 patients with acute
myeloblastic leukemia (AML) and in 5 of 16 patients with myelodysplastic
syndromes. Amplification of the c-mpl gene was detected in genomic DNA of
one M4 AML patient. There was no significant correlation between c-mpl
expression and the French-American-British classification of AML. Patients
with high c-mpl expression appeared to belong to a subgroup of AML with a
low rate of complete remission and a poor prognosis, including secondary
leukemia and AML with unfavorable cytogenetic abnormalities.
Volume 82,
Issue 3,
pp. 877-883,
08/01/1993
Copyright © 1993 by The American Society of Hematology
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