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Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells
O Rosnet, C Schiff, MJ Pebusque, S Marchetto, C Tonnelle, Y Toiron, F Birg and D Birnbaum
Centre d'Immunologie de Marseille-Luminy, France.
The human FLT3 cDNA was cloned from a pre-B cell line and characterized.
The deduced amino acid sequence shows that FLT3 codes for a receptor-type
tyrosine kinase of 993 residues, presenting a strong similarity with the
corresponding mouse FLT3/FLK2 protein as well as with the receptors for
colony-stimulating factor 1 (CSF1R/FMS) and steel locus factor (SLFR/KIT).
An analysis of the expression of the gene using amplification of reverse
transcribed FLT3 mRNA by polymerase chain reaction shows that FLT3 is
expressed in various lymphohematopoietic cells and tissues, including a
series of immature cell lines and leukemias of lymphocytic origin.
Volume 82,
Issue 4,
pp. 1110-1119,
08/15/1993
Copyright © 1993 by The American Society of Hematology
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