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Phenotypic markers and BCL-1 gene rearrangements in B-cell chronic
lymphocytic leukemia: a Cancer and Leukemia Group B study
RA Newman, B Peterson, FR Davey, C Brabyn, H Collins, VL Brunetto, DB Duggan, RB Weiss, I Royston and FE Millard
Department of Medicine, University of California San Diego Cancer Center,
La Jolla.
The markers, CD11b, CD11c, CD14, CD21, CD23, CD25, CD38, and FMC7 were
correlated with morphologic and other laboratory and clinical
characteristics of 127 patients with untreated CD5+ chronic lymphocytic
leukemia (CLL). Only CD38 and CD21 were significantly associated with
atypical CLL morphology. The integrin associated markers CD11b and CD11c
were associated with lower leukocyte count (white blood cell count [WBC])
and lower Rai stage. By contrast, the activation antigen CD23 was
associated with a higher WBC, higher Rai stage, younger age group, and the
presence of lymphadenopathy. Therefore, we conclude that CD23 positivity
may reflect a more aggressive form of CLL, and CD11b and CD11c positivity a
less aggressive form. The BCL-1 gene rearrangement was present in 5 of 84
(6%) CLL cases examined and was associated with atypical morphology and
surface expression of CD11b. Patients with a BCL-1 gene rearrangement may
represent a CLL subset or possibly a different B-cell disease.
Volume 82,
Issue 4,
pp. 1239-1246,
08/15/1993
Copyright © 1993 by The American Society of Hematology
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