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Synthesis of interleukin-5 by activated eosinophils in patients with
eosinophilic heart diseases
P Desreumaux, A Janin, S Dubucquoi, MC Copin, G Torpier, A Capron, M Capron and L Prin
Centre d'Immunologie et Biologie Parasitaire, Institut Pasteur, Lille,
France.
Eosinophilic endomyocardial disease represents a major evolutive risk in
chronic eosinophilia-associated disorders. Eosinophil granule proteins
appear to be involved in cardiac injury, but the mechanisms leading to
eosinophil infiltration and degranulation are not clear. Interleukin-5
(IL-5) has been recently shown to be produced by eosinophils and might play
a role in both chemoattraction and degranulation of eosinophils. In four
cases of eosinophilic diseases with severe cardiac failure, we evaluated
the proportion of eosinophil phenotypes and the serum levels of eosinophil
cationic protein (ECP) and soluble IL-2 receptor (sIL-2R), markers of
disease activity in the hypereosinophilic syndromes. All four patients
showed a markedly increased proportion of hypodense eosinophils with
elevated serum ECP and sIL-2R levels. In all four patients, extracellular
deposition of eosinophil granule proteins and features of eosinophil
activation were observed in cardiac tissues. The synthesis of IL-5 by
eosinophils was detected in myocardial sections and blood cells by in situ
hybridization and by immunostaining with a monoclonal antibody against
human IL-5. Sixty percent to 90% of tissue eosinophils expressed IL-5 mRNA
and IL-5 protein. These data suggest that IL-5 can be produced by
eosinophils at the sites of myocardial tissue damage and might participate
in local eosinophil activation.
Volume 82,
Issue 5,
pp. 1553-1560,
09/01/1993
Copyright © 1993 by The American Society of Hematology
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