|
|
 Previous Article | Table of Contents | Next Article 
T-cell-rich B-cell lymphoma
J Rodriguez, WC Pugh and F Cabanillas
Department of Hematology, University of Texas, M.D. Anderson Cancer Center,
Houston 77030.
We analyzed 23 cases of T-cell-rich B-cell lymphomas (BCL) to determine if
the clinical features are characteristic of a discrete entity. Cases
encoded as T-cell-rich BCL in the hematopathology archives of the
University of Texas M.D. Anderson Cancer Center between 1988 and 1991
formed the basis of this study. At least 50% of the total population of
cells were required to be of T-cell phenotype. Actually, all but one
patient had more than 70% T cells in the total population. Sixty-five
percent of all cases were referred with other diagnosis such as Hodgkin's
mixed cellularity, peripheral T-cell lymphoma (PTCL), or diffuse mixed
lymphoma, and had received therapy accordingly. With the exception of
splenomegaly, which occurred in 35% of cases, the other clinical
characteristics and the response to therapy did not indicate that this
entity represents a distinct type of lymphoma. Ann Arbor stage I-II
presentations were seen in 10 of 23 (43%) T-cell-rich BCLs. Serum lactate
dehydrogenase (LDH) was elevated in eight of 19 patients. Age, sex, and
beta 2-microglobulin were not significantly different from classical B-cell
large cell lymphoma. The clinical presentation and clinical outcome of
T-cell-rich BCL did not differ from that of common B-cell large cell
lymphoma, except for the higher proportion of splenomegaly seen in patients
with T-cell-rich BCL. The presence of the T-cell-rich infiltrate varied: it
frequently was not seen at relapse or at other sites of disease at
presentation. It was thus considered an unstable parameter. The major
importance of identifying this entity is to distinguish it pathologically
from other disorders such as Hodgkin's disease and PTCL, which would be
treated in a different manner.
Volume 82,
Issue 5,
pp. 1586-1589,
09/01/1993
Copyright © 1993 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. S. Abramson
T-cell/histiocyte-rich B-cell lymphoma: biology, diagnosis, and management.
Oncologist,
April 1, 2006;
11(4):
384 - 392.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Bouabdallah, N. Mounier, C. Guettier, T. Molina, V. Ribrag, C. Thieblemont, A. Sonet, A. Delmer, K. Belhadj, P. Gaulard, et al.
T-Cell/Histiocyte-Rich Large B-Cell Lymphomas and Classical Diffuse Large B-Cell Lymphomas Have Similar Outcome After Chemotherapy: A Matched-Control Analysis
J. Clin. Oncol.,
April 1, 2003;
21(7):
1271 - 1277.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Achten, G. Verhoef, L. Vanuytsel, and C. De Wolf-Peeters
T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Distinct Clinicopathologic Entity
J. Clin. Oncol.,
March 1, 2002;
20(5):
1269 - 1277.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Walton and M. J. Hendrick
Feline Hodgkin's-like Lymphoma: 20 Cases (1992-1999)
Vet. Pathol.,
September 1, 2001;
38(5):
504 - 511.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Anagnostopoulos, M.-L. Hansmann, K. Franssila, M. Harris, N. L. Harris, E. S. Jaffe, J. Han, J. M. van Krieken, S. Poppema, T. Marafioti, et al.
European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes
Blood,
September 1, 2000;
96(5):
1889 - 1899.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Brauninger, R. Kuppers, T. Spieker, R. Siebert, J. G. Strickler, B. Schlegelberger, K. Rajewsky, and M.-L. Hansmann
Molecular Analysis of Single B Cells From T-Cell-Rich B-Cell Lymphoma Shows the Derivation of the Tumor Cells From Mutating Germinal Center B Cells and Exemplifies Means by Which Immunoglobulin Genes Are Modified in Germinal Center B Cells
Blood,
April 15, 1999;
93(8):
2679 - 2687.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Felgar, K. R. Steward, J. B. Cousar, and W. R. Macon
T-Cell-Rich Large-B-Cell Lymphomas Contain Non-Activated CD8+ Cytolytic T Cells, Show Increased Tumor Cell Apoptosis, and Have Lower Bcl-2 Expression Than Diffuse Large-B-Cell Lymphomas
Am. J. Pathol.,
December 1, 1998;
153(6):
1707 - 1715.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Jennings and K. A. Foon
Recent Advances in Flow Cytometry: Application to the Diagnosis of Hematologic Malignancy
Blood,
October 15, 1997;
90(8):
2863 - 2892.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Wang, P. D. Unger, and J. A. Strauchen
T-Cell-Rich B-Large-Cell Lymphoma Simulating Hodgkin's Disease: Report of Two Cases with Transformation to Pleomorphic B-Large-Cell Lymphoma
International Journal of Surgical Pathology,
July 1, 1997;
5(1-2):
31 - 36.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Melnyk, A. Rodriguez, W.C. Pugh, and F. Cabannillas
Evaluation of the Revised European-American Lymphoma Classification Confirms the Clinical Relevance of Immunophenotype in 560 Cases of Aggressive Non-Hodgkin's Lymphoma
Blood,
June 15, 1997;
89(12):
4514 - 4520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
