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E-selectin and vascular cell adhesion molecule-1 mediate adult T-cell
leukemia cell adhesion to endothelial cells
T Ishikawa, A Imura, K Tanaka, H Shirane, M Okuma and T Uchiyama
Research Center for Immunodeficiency Virus, Kyoto University, Japan.
We studied the adhesion properties of peripheral blood leukemic cells from
10 patients with adult T-cell leukemia (ATL) to endothelial cells to better
understand the mechanism of leukemic cell infiltration. ATL cells expressed
lymphocyte function-associated antigen-1 (LFA-1), but the expression of
very late antigen-4 (VLA-4) and sialyl-Lewisx (SLex) was variable. They did
not express sialyl-Lewisa (SLea). Cell adhesion assays, which were
performed in nine patients, showed marked adhesion of ATL cells to
interleukin [IL]-1-activated human umbilical vein endothelial cells
(HUVEC). A monoclonal antibody (MoAb) against E- selectin consistently
inhibited ATL cell adhesion, and an MoAb against vascular cell adhesion
molecule-1 (VCAM-1) or an MoAb against VLA-4 sometimes diminished it. In
contrast, an MoAb against LFA-1 had a minor effect on freshly isolated ATL
cell adhesion to HUVEC. The percentage of SLex+ cells in the cell
population adherent to IL-1-activated HUVEC was slightly higher than that
in unseparated cells. These results, together with the detection of
E-selectin expression on the endothelium at ATL skin lesions, indicate that
E-selectin-mediated adhesion is the major pathway for the adherence of ATL
cells to endothelial cells. In addition, the ligand for E-selectin on ATL
cells appears to differ from that on neutrophils.
Volume 82,
Issue 5,
pp. 1590-1598,
09/01/1993
Copyright © 1993 by The American Society of Hematology
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