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A comparison of the iron-clearing properties of parabactin and desferrioxamine

R Bergeron, RR Streiff, W King, RD Daniels and J Wiegand

Department of Medicinal Chemistry, University of Florida, Gainesville 32610.

A comparative study of the iron-clearing properties of subcutaneously administered desferrioxamine and parabactin is presented. The evaluation was performed in both a non-iron-overloaded bile-duct cannulated rat and an iron-loaded Cebus monkey model. Parabactin was superior to desferrioxamine in both the rodent and the primate. Unlike desferrioxamine, nearly all of the parabactin-induced iron clearance occurred in the bile. This study represents an evaluation of the iron- clearing properties of parabactin, a hexacoordinate catecholamide siderophore.

Volume 82, Issue 8, pp. 2552-2557, 10/15/1993
Copyright © 1993 by The American Society of Hematology


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