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Granulocyte colony-stimulating factor receptor mRNA upregulation is an
immediate early marker of myeloid differentiation and exhibits
dysfunctional regulation in leukemic cells
RA Steinman and DJ Tweardy
Department of Medicine, University of Pittsburgh School of Medicine, PA.
The identification of early markers of myeloid differentiation can
facilitate an understanding of how differentiation is arrested in
leukemogenesis. Using murine bone marrow and the granulocyte-precusor cell
line 32Dc13, we show that message for the granulocyte colony- stimulating
factor receptor (G-CSFR) is upregulated by G-CSF in an immediate early
fashion that is specific to the differentiation pathway and is antagonized
by interleukin-3. We further show that G-CSFR message is superinduced by
cycloheximide and that these patterns of regulation are altered in leukemic
cell lines. In particular, the v-abl oncogene product supresses both
ligand-mediated upregulation and superinduction of the G-CSFR gene.
Volume 83,
Issue 1,
pp. 119-127,
01/01/1994
Copyright © 1994 by The American Society of Hematology
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