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Alterations of the p53 tumor suppressor gene in diffuse large cell
lymphomas with translocations of the c-MYC and BCL-2 proto-oncogenes
MM Farrugia, LJ Duan, MD Reis, BY Ngan and NL Berinstein
Department of Immunology, University of Toronto, Ontario, Canada.
Diffuse large cell lymphomas are aggressive tumors of B-cell origin. In
some cases they arise from low-grade follicular lymphomas carrying the
t(14;18) translocation, an event that leads to the overexpression of the
BCL-2 gene product. More frequently, however, they lack the t(14;18)
translocation. Rearrangements of the c-MYC proto-oncogene and mutations of
the p53 tumor suppressor gene have also been documented in these lymphomas.
This study examines the extent to which alterations in the BCL-2, c-MYC,
and p53 genes co-exist within individual lymphomas. Eight diffuse large
cell lymphoma cell lines and 11 diffuse large cell lymphoma tumors were
assessed for genetic alterations in these three genes. Our results indicate
that there is a heterogeneity in the oncogene/suppressor gene profile among
diffuse large cell lymphomas. Two cell lines and one tumor carried
alterations in all three genes, one cell line carried alterations of c-MYC
and p53, and one primary tumor and one cell line carried p53 mutations and
the t(14;18). Single alterations of BCL-2 and p53 were also observed.
Another cell line had no alterations in any of these genes. The
heterogeneity indicates that varied mechanisms may be involved in the
generation of diffuse large cell lymphomas.
Volume 83,
Issue 1,
pp. 191-198,
01/01/1994
Copyright © 1994 by The American Society of Hematology
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