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Gene involved in the 3q27 translocation associated with B-cell lymphoma,
BCL5, encodes a Kruppel-like zinc-finger protein
T Miki, N Kawamata, S Hirosawa and N Aoki
First Department of Internal Medicine, Tokyo Medical and Dental University,
Japan.
Chromosomal translocations involving band 3q27 are the recently described
nonrandom cytogenetic abnormalities in B-cell malignancies. We have
previously cloned the breakpoint region of 3q27, designated as the BCL5
locus, from the B-cell line carrying the t(3;22). The cDNA for the BCL5
gene was cloned from the human liver cDNA library. The nucleotide
sequencing analysis showed that the BCL5 gene encodes a potential
transcription factor containing six repeats of the Cys2-His2 zinc-finger
motif resembling the Drosophila segmentation gene Kruppel. The calculated
molecular weight was 78.8 kD, which was supported by an in vitro
transcription and translation experiment. A part of the sequence was
essentially identical to that of a genomic fragment, ZNF51, previously
reported to be located at 3qter. The translocation occurred in the 5'
region of the BCL5 gene, and the protein-coding exons were fused to the
Ig-lambda gene in a head-to-head configuration in the cell line carrying
t(3;22). The BCL5 cDNA probe detected a major transcript of 3.8 kb in
Burkitt's lymphoma cell lines and an aberrant transcript in the t(3;22)
cell line, whereas no transcript was detected in myeloid, monocytoid,
erythroid, T-lymphoid, and Epstein-Barr virus- immortalized
B-lymphoblastoid cell lines.
Volume 83,
Issue 1,
pp. 26-32,
01/01/1994
Copyright © 1994 by The American Society of Hematology
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