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A bone marrow stromal-derived growth factor, interleukin-11, stimulates
recovery of small intestinal mucosal cells after cytoablative therapy
XX Du, CM Doerschuk, A Orazi and DA Williams
Herman B. Wells Center for Pediatric Research, James Whitcomb Riley
Hospital for Children, Indianapolis, IN.
The proliferation of epithelial cells lining the small intestinal mucosa
may be regulated by microenvironmental signals leading to differentiation
of precursor cells in the small intestinal crypts. Proliferation of
hematopoietic cells within the hematopoietic microenvironment is known to
be regulated by a growing number of glycoprotein growth factors in a
hierarchial fashion. We studied the effects of administration of the
microenvironment-derived hematopoietic growth factor interleukin-11 (IL-11)
on mice given combination radiation/chemotherapy. Treatment of such mice
with IL-11 led to significantly increased survival and evidence of rapid
recovery of the small intestinal mucosa, which is severely damaged by these
cytoxic agents. This recovery was associated with an increase in the
mitotic index of crypt cells and an increased frequency of staining of
these cells with a monoclonal antibody to proliferating cell nuclear
antigen, a member of the cyclin family of nuclear antigens.
Volume 83,
Issue 1,
pp. 33-37,
01/01/1994
Copyright © 1994 by The American Society of Hematology
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