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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tsai, L. Articles by Ozanne, B Search for Related Content PubMed PubMed Citation Articles by Tsai, L. Articles by Ozanne, B Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Expression of platelet-derived growth factor and its receptors by two pre-B acute lymphocytic leukemia cell lines LH Tsai, L White, E Raines, R Ross, RG Smith, W Cushley and B Ozanne CRC Beatson Laboratories, Bearsden, Glasgow, Scotland. Platelet-derived growth factors (PDGF) are potent regulators of cell proliferation. The three isoforms of PDGF AA, AB, and BB are encoded by two genes: PDGF A and PDGF B. The v-sis oncogene is homologous to the PDGF-B gene. v-sis can transform cells that express the appropriate PDGF receptors. Two different types of receptors, PDGF-alpha and PDGF- beta, also encoded by two genes, have been identified. We show that two cell lines. SMS-SB and NALM-6, both derived from pre-B-cell acute lymphocytic leukemias, express the PDGF-A chain gene, and one of them, SMS-SB, releases PDGF-A chains into the media. The SMS-SB cells also express the PDGF-beta receptor, whereas NALM-6 cells express the PDGF- alpha receptor and bind PDGF. This extends the possible targets for PDGF to the B-cell lineage lymphocytes. Volume 83, Issue 1, pp. 51-55, 01/01/1994 Copyright © 1994 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 1994 by American Society of Hematology         Online ISSN: 1528-0020