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Effects of stem cell factor (kit-ligand) and interleukin-3 on the growth
and serine proteinase expression of rat bone-marrow-derived or serosal mast
cells
DM Haig, JF Huntley, A MacKellar, GF Newlands, L Inglis, R Sangha, D Cohen, A Hapel, SJ Galli and HR Miller
Moredun Research Institute, Edinburgh, Scotland, UK.
The effects of rat stem-cell factor (SCF) and interleukin-3 (IL-3), alone
or in combination, on the in vitro growth and serine proteinase expression
of rat serosal/connective-tissue mast cells (CTMC) or bone marrow-derived
mast cells (BMMC) were examined. Rat SCF stimulated the growth of both CTMC
and BMMC. IL-3 stimulated BMMC growth to a lesser extent than did SCF,
whereas CTMC numbers did not increase in IL-3. However, SCF and IL-3 had
synergistic effects on the growth of both BMMC and CTMC. SCF favoured the
maintenance of rat mast cell proteinase- I (RMCP-I) in CTMC, but did not
induce detectable production of RMCP-I in BMMC. In contrast, when IL-3 or
lymph node-conditioned medium (LNCM) was added to SCF, a subpopulation of
CTMC expressed and stored the soluble proteinase RMCP-II. In BMMC, the
RMCP-II content of cells maintained in SCF was significantly less than that
of cells maintained in IL-3 or LNCM. RMCP-II also appeared in the
supernatants of BMMC, especially when BMMC numbers were increasing rapidly
in SCF with or without IL-3 or LNCM. Thus, SCF and IL-3 can regulate the
growth of rat BMMC and CTMC, as well as influence their production and
release of proteinases.
Volume 83,
Issue 1,
pp. 72-83,
01/01/1994
Copyright © 1994 by The American Society of Hematology
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