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Cloning of the human homologue of the murine flt3 ligand: a growth factor
for early hematopoietic progenitor cells
SD Lyman, L James, L Johnson, K Brasel, P de Vries, SS Escobar, H Downey, RR Splett, MP Beckmann and HJ McKenna
Department of Molecular Genetics, Immunex Research and Development Corp,
Seattle, WA 98101.
Using a fragment of the murine flt3 ligand as a probe, we have succeeded in
cloning a human flt3 ligand from a human T-cell lambda gt10 cDNA library.
The human and murine ligands are 72% identical at the amino acid level.
Analysis of multiple cDNA clones shows that alternative splicing of the
human flt3 mRNA can occur at a number of positions. A recombinant soluble
form of the human flt3 ligand stimulates the proliferation and colony
formation of a subpopulation of human bone marrow cells that are CD34+ and
are enriched for primitive hematopoietic cells. In addition, the human flt3
ligand also stimulates the proliferation of cells expressing murine flt3
receptors. Northern blot analysis shows widespread expression of flt3
ligand mRNA transcripts in human tissues.
Volume 83,
Issue 10,
pp. 2795-2801,
05/15/1994
Copyright © 1994 by The American Society of Hematology
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