|
|
 Previous Article | Table of Contents | Next Article 
Cloning of the human homologue of the murine flt3 ligand: a growth factor
for early hematopoietic progenitor cells
SD Lyman, L James, L Johnson, K Brasel, P de Vries, SS Escobar, H Downey, RR Splett, MP Beckmann and HJ McKenna
Department of Molecular Genetics, Immunex Research and Development Corp,
Seattle, WA 98101.
Using a fragment of the murine flt3 ligand as a probe, we have succeeded in
cloning a human flt3 ligand from a human T-cell lambda gt10 cDNA library.
The human and murine ligands are 72% identical at the amino acid level.
Analysis of multiple cDNA clones shows that alternative splicing of the
human flt3 mRNA can occur at a number of positions. A recombinant soluble
form of the human flt3 ligand stimulates the proliferation and colony
formation of a subpopulation of human bone marrow cells that are CD34+ and
are enriched for primitive hematopoietic cells. In addition, the human flt3
ligand also stimulates the proliferation of cells expressing murine flt3
receptors. Northern blot analysis shows widespread expression of flt3
ligand mRNA transcripts in human tissues.
Volume 83,
Issue 10,
pp. 2795-2801,
05/15/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Sekine, K. Kataoka, Y. Fukuyama, Y. Adachi, J. Davydova, M. Yamamoto, R. Kobayashi, K. Fujihashi, H. Suzuki, D. T. Curiel, et al.
A Novel Adenovirus Expressing Flt3 Ligand Enhances Mucosal Immunity by Inducing Mature Nasopharyngeal-Associated Lymphoreticular Tissue Dendritic Cell Migration
J. Immunol.,
June 15, 2008;
180(12):
8126 - 8134.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. L. Papenfuss, A. P. Kithcart, N. D. Powell, M. A. McClain, I. E. Gienapp, T. M. Shawler, and C. C. Whitacre
Disease-modifying capability of murine Flt3-ligand DCs in experimental autoimmune encephalomyelitis
J. Leukoc. Biol.,
December 1, 2007;
82(6):
1510 - 1518.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Buza-Vidas, M. Cheng, S. Duarte, H. Nozad, S. E. W. Jacobsen, and E. Sitnicka
Crucial role of FLT3 ligand in immune reconstitution after bone marrow transplantation and high-dose chemotherapy
Blood,
July 1, 2007;
110(1):
424 - 432.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Edwan, G. Perry, J. E. Talmadge, and D. K. Agrawal
Flt-3 Ligand Reverses Late Allergic Response and Airway Hyper-Responsiveness in a Mouse Model of Allergic Inflammation
J. Immunol.,
April 15, 2004;
172(8):
5016 - 5023.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ozeki, H. Kiyoi, Y. Hirose, M. Iwai, M. Ninomiya, Y. Kodera, S. Miyawaki, K. Kuriyama, C. Shimazaki, H. Akiyama, et al.
Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia
Blood,
March 1, 2004;
103(5):
1901 - 1908.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Higano, N. J. Vogelzang, J. A. Sosman, A. Feng, D. Caron, and E. J Small
Safety and Biological Activity of Repeated Doses of Recombinant Human Flt3 Ligand in Patients with Bone Scan-Negative Hormone-Refractory Prostate Cancer
Clin. Cancer Res.,
February 15, 2004;
10(4):
1219 - 1225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Gilliland and J. D. Griffin
The roles of FLT3 in hematopoiesis and leukemia
Blood,
August 13, 2002;
100(5):
1532 - 1542.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Li, L. Lu, Z. Wang, L. Wang, J. J. Fung, A. W. Thomson, and S. Qian
IL-12 Antagonism Enhances Apoptotic Death of T Cells Within Hepatic Allografts from Flt3 Ligand-Treated Donors and Promotes Graft Acceptance
J. Immunol.,
May 1, 2001;
166(9):
5619 - 5628.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Chklovskaia, C. Nissen, L. Landmann, C. Rahner, O. Pfister, and A. Wodnar-Filipowicz
Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor {gamma}-chain signaling and inhibited by cyclosporin A
Blood,
February 15, 2001;
97(4):
1027 - 1034.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Mwangi, W. C. Brown, and G. H. Palmer
Identification of Fetal Liver Tyrosine Kinase 3 (Flt3) Ligand Domain Required for Receptor Binding and Function Using Naturally Occurring Ligand Isoforms
J. Immunol.,
December 15, 2000;
165(12):
6966 - 6974.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mizuki, R. Fenski, H. Halfter, I. Matsumura, R. Schmidt, C. Muller, W. Gruning, K. Kratz-Albers, S. Serve, C. Steur, et al.
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
Blood,
December 1, 2000;
96(12):
3907 - 3914.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Zhang, S. Fukuda, Y. Lee, G. Hangoc, S. Cooper, R. Spolski, W. J. Leonard, and H. E. Broxmeyer
Essential Role of Signal Transducer and Activator of Transcription (Stat)5a but Not Stat5b for Flt3-Dependent Signaling
J. Exp. Med.,
September 5, 2000;
192(5):
719 - 728.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Solanilla, J. Dechanet, A. El Andaloussi, M. Dupouy, F. Godard, J. Chabrol, P. Charbord, J. Reiffers, A. T. Nurden, B. Weksler, et al.
CD40-ligand stimulates myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells
Blood,
June 15, 2000;
95(12):
3758 - 3764.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Wang, S. E. Braun, G. Sonpavde, and K. Cornetta
Antileukemic Activity of Flt3 Ligand in Murine Leukemia
Cancer Res.,
April 1, 2000;
60(7):
1895 - 1900.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C.-C. Shih, M. C.-T. Hu, J. Hu, Y. Weng, P. J. Yazaki, J. Medeiros, and S. J. Forman
A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells
Blood,
March 15, 2000;
95(6):
1957 - 1966.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Wolf and L. R. Rohrschneider
Fiz1, a Novel Zinc Finger Protein Interacting with the Receptor Tyrosine Kinase Flt3
J. Biol. Chem.,
July 23, 1999;
274(30):
21478 - 21484.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Chklovskaia, W. Jansen, C. Nissen, S. D. Lyman, C. Rahner, L. Landmann, and A. Wodnar-Filipowicz
Mechanism of flt3 Ligand Expression in Bone Marrow Failure: Translocation From Intracellular Stores to the Surface of T Lymphocytes After Chemotherapy-Induced Suppression of Hematopoiesis
Blood,
April 15, 1999;
93(8):
2595 - 2604.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-F. Arrighi, C. Hauser, B. Chapuis, R. H. Zubler, and V. Kindler
Long-Term Culture of Human CD34+ Progenitors With FLT3-Ligand, Thrombopoietin, and Stem Cell Factor Induces Extensive Amplification of a CD34-CD14- and a CD34-CD14+ Dendritic Cell Precursor
Blood,
April 1, 1999;
93(7):
2244 - 2252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Goff, D. S. Shields, and J. S. Greenberger
Influence of Cytokines on the Growth Kinetics and Immunophenotype of Daughter Cells Resulting From the First Division of Single CD34+Thy-1+lin- Cells
Blood,
December 1, 1998;
92(11):
4098 - 4107.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Yu, T. A. Fehniger, P. Fuchshuber, K. S. Thiel, E. Vivier, W. E. Carson, and M. A. Caligiuri
Flt3 Ligand Promotes the Generation of a Distinct CD34+ Human Natural Killer Cell Progenitor That Responds to Interleukin-15
Blood,
November 15, 1998;
92(10):
3647 - 3657.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Neipp, T. Zorina, M. A. Domenick, B. G. Exner, and S. T. Ildstad
Effect of FLT3 Ligand and Granulocyte Colony-Stimulating Factor on Expansion and Mobilization of Facilitating Cells and Hematopoietic Stem Cells in Mice: Kinetics and Repopulating Potential
Blood,
November 1, 1998;
92(9):
3177 - 3188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Moore, D. N. Haylock, J.-P. Levesque, L. A. McDiarmid, L. M. Samels, L. B. To, P. J. Simmons, and T. P. Hughes
Stem Cell Factor as a Single Agent Induces Selective Proliferation of the Philadelphia Chromosome Positive Fraction of Chronic Myeloid Leukemia CD34+ Cells
Blood,
October 1, 1998;
92(7):
2461 - 2470.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Kapp, M. Bhatia, D. Bonnet, B. Murdoch, and J. E. Dick
Treatment of Non-Obese Diabetic (NOD)/Severe-Combined Immunodeficient Mice (SCID) With flt3 Ligand and Interleukin-7 Impairs the B-Lineage Commitment of Repopulating Cells After Transplantation of Human Hematopoietic Cells
Blood,
September 15, 1998;
92(6):
2024 - 2031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Graddis, K. Brasel, D. Friend, S. Srinivasan, S. Wee, S. D. Lyman, C. J. March, and J. T. McGrew
Structure-Function Analysis of FLT3 Ligand-FLT3 Receptor Interactions Using a Rapid Functional Screen
J. Biol. Chem.,
July 10, 1998;
273(28):
17626 - 17633.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Antonysamy, R. J. Steptoe, A. Khanna, W. A. Rudert, V. M. Subbotin, and A. W. Thomson
Flt-3 Ligand Increases Microchimerism But Can Prevent the Therapeutic Effect of Donor Bone Marrow in Transiently Immunosuppressed Cardiac Allograft Recipients
J. Immunol.,
April 15, 1998;
160(8):
4106 - 4113.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. S. Gotze, M. Ramirez, K. Tabor, D. Small, W. Matthews, and C. I. Civin
Flt3high and Flt3low CD34+ Progenitor Cells Isolated From Human Bone Marrow Are Functionally Distinct
Blood,
March 15, 1998;
91(6):
1947 - 1958.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Lyman and S. E. W. Jacobsen
c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities
Blood,
February 15, 1998;
91(4):
1101 - 1134.
[Full Text]
[PDF]
|
|
|
|
|
|
|
N Fortunel, P Batard, A Hatzfeld, M. Monier, B Panterne, J Lebkowski, and J Hatzfeld
High proliferative potential-quiescent cells: a working model to study primitive quiescent hematopoietic cells
J. Cell Sci.,
January 7, 1998;
111(13):
1867 - 1875.
[Abstract]
[PDF]
|
|
|
|
|
|
|
O. P. Veiby, O. J. Borge, A. Martensson, E. X. Beck, A. E. Schade, K. Grzegorzewski, S. D. Lyman, I.-L. Martensson, and S. E.W. Jacobsen
Bidirectional Effect of Interleukin-10 on Early Murine B-Cell Development: Stimulation of flt3-Ligand Plus Interleukin-7-Dependent Generation of CD19- ProB Cells From Uncommitted Bone Marrow Progenitor Cells and Growth Inhibition of CD19+ ProB Cells
Blood,
December 1, 1997;
90(11):
4321 - 4331.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Ebihara, K. Tsuji, S. D. Lyman, X. Sui, M. Yoshida, K. Muraoka, K. Yamada, R. Tanaka, and T. Nakahata
Synergistic Action of Flt3 and gp130 Signalings in Human Hematopoiesis
Blood,
December 1, 1997;
90(11):
4363 - 4368.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. C. Dooley, M. Xiao, B. K. Oppenlander, J. M. Plunkett, and S. D. Lyman
Flt3 Ligand Enhances the Yield of Primitive Cells After Ex Vivo Cultivation of CD34+ CD38dim Cells and CD34+ CD38dim CD33dim HLA-DR+ Cells
Blood,
November 15, 1997;
90(10):
3903 - 3913.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Brasel, H. J. McKenna, K. Charrier, P. J. Morrissey, D. E. Williams, and S. D. Lyman
Flt3 Ligand Synergizes With Granulocyte-Macrophage Colony-Stimulating Factor or Granulocyte Colony-Stimulating Factor to Mobilize Hematopoietic Progenitor Cells Into the Peripheral Blood of Mice
Blood,
November 1, 1997;
90(9):
3781 - 3788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. N. Haylock, M. J. Horsfall, T. L. Dowse, H. S. Ramshaw, S. Niutta, S. Protopsaltis, L. Peng, C. Burrell, I. Rappold, H.-J. Buhring, et al.
Increased Recruitment of Hematopoietic Progenitor Cells Underlies the Ex Vivo Expansion Potential of FLT3 Ligand
Blood,
September 15, 1997;
90(6):
2260 - 2272.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Strobl, C. Bello-Fernandez, E. Riedl, W. F. Pickl, O. Majdic, S. D. Lyman, and W. Knapp
flt3 Ligand in Cooperation With Transforming Growth Factor-beta 1 Potentiates In Vitro Development of Langerhans-Type Dendritic Cells and Allows Single-Cell Dendritic Cell Cluster Formation Under Serum-Free Conditions
Blood,
August 15, 1997;
90(4):
1425 - 1434.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Papayannopoulou, B. Nakamoto, R. G. Andrews, S. D. Lyman, and M. Y. Lee
In Vivo Effects of Flt3/Flk2 Ligand on Mobilization of Hematopoietic Progenitors in Primates and Potent Synergistic Enhancement With Granulocyte Colony-Stimulating Factor
Blood,
July 15, 1997;
90(2):
620 - 629.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. S.-C. Juan, I. K. McNiece, G. Van, D. Lacey, C. Hartley, P. McElroy, Y. Sun, J. Argento, D. Hill, X.-Q. Yan, et al.
Chronic Expression of Murine flt3 Ligand in Mice Results in Increased Circulating White Blood Cell Levels and Abnormal Cellular Infiltrates Associated With Splenic Fibrosis
Blood,
July 1, 1997;
90(1):
76 - 84.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Rappold, B. L. Ziegler, I. Kohler, S. Marchetto, O. Rosnet, D. Birnbaum, P. J. Simmons, A. C.W. Zannettino, B. Hill, S. Neu, et al.
Functional and Phenotypic Characterization of Cord Blood and Bone Marrow Subsets Expressing FLT3 (CD135) Receptor Tyrosine Kinase
Blood,
July 1, 1997;
90(1):
111 - 125.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Molineux, C. McCrea, X. Q. Yan, P. Kerzic, and I. McNiece
Flt-3 Ligand Synergizes With Granulocyte Colony-Stimulating Factor to Increase Neutrophil Numbers and to Mobilize Peripheral Blood Stem Cells With Long-Term Repopulating Potential
Blood,
June 1, 1997;
89(11):
3998 - 4004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Sudo, C. Shimazaki, E. Ashihara, T. Kikuta, H. Hirai, T. Sumikuma, N. Yamagata, H. Goto, T. Inaba, N. Fujita, et al.
Synergistic Effect of FLT-3 Ligand on the Granulocyte Colony-Stimulating Factor-Induced Mobilization of Hematopoietic Stem Cells and Progenitor Cells Into Blood in Mice
Blood,
May 1, 1997;
89(9):
3186 - 3191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Piacibello, F. Sanavio, L. Garetto, A. Severino, D. Bergandi, J. Ferrario, F. Fagioli, M. Berger, and M. Aglietta
Extensive Amplification and Self-Renewal of Human Primitive Hematopoietic Stem Cells From Cord Blood
Blood,
April 15, 1997;
89(8):
2644 - 2653.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Gattei, A. Celetti, A. Cerrato, M. Degan, A. De Iuliis, F. M. Rossi, G. Chiappetta, C. Consales, S. Improta, V. Zagonel, et al.
Expression of the RET Receptor Tyrosine Kinase and GDNFR-alpha in Normal and Leukemic Human Hematopoietic Cells and Stromal Cells of the Bone Marrow Microenvironment
Blood,
April 15, 1997;
89(8):
2925 - 2937.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
