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Roles for integrin very late activation antigen-4 in stroma-dependent
erythropoiesis
N Yanai, C Sekine, H Yagita and M Obinata
Department of Cell Biology, Tohoku University, Sendai, Japan.
Adhesion molecules are required for development of hematopoietic stem and
progenitor cells in the respective hematopoietic microenvironments. We
previously showed that development of the erythroid progenitor cells is
dependent on their direct adhesion to the stroma cells established from the
erythropoietic organs. In this stroma-dependent erythropoiesis, we examined
the role of adhesion molecules in erythropoiesis by blocking antibodies.
The development of the erythroid cells on stroma cells was inhibited by
anti-very late activation antigen-4 (VLA-4 integrin) antibody, but not by
anti-VLA-5 antibody, although the erythroid cells express both VLA-4 and
VLA-5. Whereas high levels of expression of vascular cell adhesion
molecule-1 (VCAM-1) and fibronectin, ligands for VLA-4, were detected in
the stroma cells, the adhesion and development of the erythroid progenitor
cells were partly inhibited by the blocking antibody against VCAM-1. VLA-5
and fibronectin could mediate adhesion of the erythroid progenitor cells to
the stromal cells, but the adhesion itself may not be sufficient for the
stroma-supported erythropoiesis. The stromal cells may support erythroid
development by the adhesion through a new ligand molecule(s) for VLA-4 in
addition to VCAM-1, and such collaborative interaction may provide adequate
signaling for the erythroid progenitor cells in the erythropoietic
microenvironment.
Volume 83,
Issue 10,
pp. 2844-2850,
05/15/1994
Copyright © 1994 by The American Society of Hematology
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