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Regulation by interleukin-2 (IL-2) and interferon gamma of IL-2 receptor
gamma chain gene expression in human monocytes
MC Bosco, I Espinoza-Delgado, M Schwabe, GL Gusella, DL Longo, K Sugamura and L Varesio
Laboratory of Experimental Immunology, National Cancer Institute- Frederick
Cancer Research and Development Center 21702-1201.
The interleukin-2 receptor gamma chain (IL-2R gamma) gene codes for a
subunit of the IL-2R and is expressed in human lymphoid cells. The present
study was undertaken to determine whether human monocytes expressed the
IL-2R gamma gene constitutively or after activation by IL- 2 or interferon
gamma (IFN gamma). Fresh human monocytes constitutively expressed low but
significant levels of IL-2R gamma mRNA, and nuclear run-on experiments
showed that IL-2R gamma gene was transcriptionally active. Stimulation with
IL-2 or IFN gamma induced a major increase of IL-2R gamma mRNA in a time-
and a dose-dependent manner. However, neither cytokine increased the
transcriptional activity of the gene. The enhancement of IL-2R gamma mRNA
expression by either IL-2 or IFN gamma was concomitant with the
stabilization of the mRNA, suggesting a postranscriptional level of
control. Finally, the augmented expression of IL-2R gamma in IL-2- and IFN
gamma-treated monocytes was associated with an increased IL-2-binding
activity, compared with that of unstimulated cells. These results provide
the first evidence of the expression of the IL-2R gamma gene in nonlymphoid
cells and of its modulation by IL-2 and IFN gamma through
posttranscriptional mechanisms.
Volume 83,
Issue 10,
pp. 2995-3002,
05/15/1994
Copyright © 1994 by The American Society of Hematology
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