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Isolation and characterization of the human interleukin-9 receptor gene
MS Chang, G Engel, C Benedict, R Basu and J McNinch
Department of Developmental Biology, Amgen Inc. Thousand Oaks, CA 91361.
To better understand the regulation of interleukin-9 (IL-9) receptor
expression, we have isolated the genomic clone of the human IL-9 receptor
based on its sequence homology with a human IL-9 receptor cDNA isolated
from the human megakaryocyte cell line UT-7. The entire genomic structure
has been determined. The human IL-9 receptor gene consists of 10 exons
spread over approximately 13.7 kb of DNA. The nucleotide sequence of the
coding region from the genomic DNA is identical to our cDNA clone. Several
blocks of transcriptional control sequence have been identified at the 5'
noncoding region of the IL-9 receptor gene that may play an important role
in the regulation of the IL-9 receptor gene. A fusion gene containing 659
bp of human IL-9 receptor 5' noncoding region linked to the firefly
luciferase gene directed expression of luciferase activity in human
embryonic kidney 293 cell line, but not in the mouse fibroblast cell line
NIH3T3 cells.
Volume 83,
Issue 11,
pp. 3199-3205,
06/01/1994
Copyright © 1994 by The American Society of Hematology
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