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Association of p72 tyrosine kinase with Stat factors and its activation by
interleukin-3, interleukin-6, and granulocyte colony-stimulating factor
T Matsuda and T Hirano
Division of Molecular Oncology, Osaka University Medical School, Japan.
Hematopoietic cytokines, including interleukin-3 (IL-3), IL-6, and
granulocyte colony-stimulating factor (G-CSF), induce the proliferation,
differentiation, and activation of hematopoietic lineage cells. These
cytokines activate the Jak/Stat-mediated signal transduction pathway that
is important in the biologic activities of these cytokines. In this study,
we showed that hematopoietic cytokines, such as IL-3, IL-6, and G-CSF, all
induced tyrosine-phosphorylation of Stat family proteins and
Stat-associated 150-kD and 72-kD molecules in hematopoietic lineage cell
lines. Furthermore, we showed that the 72-kD molecule had tyrosine kinase
activity. The tyrosine kinase activity of the 72-kD molecule was enhanced
by the stimulation through an IL-6 signal transducer, gp130, that was
shared among the receptors for the IL-6-related cytokine subfamily, such as
leukemia inhibitory factor, oncostatin M, IL-11, and ciliary neurotrophic
factor. Because 72-kD tyrosine kinase was distinct from Syk, Tec, and Btk
and coimmunoprecipitated with anti-Stat antiserum, we termed it Stat-
associated 72-kD tyrosine kinase (p72sak). p72sak may directly activate
Stat family proteins or other signal transducing molecules for IL-3, G-
CSF, and the IL-6-related cytokine subfamily.
Volume 83,
Issue 12,
pp. 3457-3461,
06/15/1994
Copyright © 1994 by The American Society of Hematology
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