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The gamma subunit of the interleukin-2 receptor is expressed in human
monocytes and modulated by interleukin-2, interferon gamma, and
transforming growth factor beta 1
MC Bosco, I Espinoza-Delgado, M Schwabe, SM Russell, WJ Leonard, DL Longo and L Varesio
Laboratory of Experimental Immunology, National Cancer Institute- Frederick
Cancer Research and Development Center, MD 21702-1201.
The interleukin-2 receptor gamma (IL-2R gamma) chain is a newly recognized
component of the IL-2R of lymphoid cells that is required for their
response to IL-2. We investigated the expression of IL-2R gamma protein in
human monocytes by Western blot analysis using an antiserum specific for
IL-2R gamma. We found that IL-2R gamma subunit is constitutively expressed
in human monocytes and upregulated by the monocyte-activating factors IL-2
and interferon gamma (IFN gamma). Furthermore, we show that transforming
growth factor beta 1 (TGF beta 1) downmodulates, in a dose-dependent
manner, basal and IL-2-induced, but not IFN gamma-induced, IL-2R gamma
chain expression, and this effect may be responsible for TGF beta 1
suppressive activity on IL-2- activated monocytes. Overall, these results
show that the expression of the IL-2R gamma subunit in human monocytes is
tightly regulated by the cytokine network, suggesting a critical role
played by this protein on monocyte activation.
Volume 83,
Issue 12,
pp. 3462-3467,
06/15/1994
Copyright © 1994 by The American Society of Hematology
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