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Similar patterns of V kappa gene usage but different degrees of somatic
mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's
macroglobulinemia, and myeloma
SD Wagner, V Martinelli and L Luzzatto
Department of Haematology, Royal Postgraduate Medical School, Hammersmith
Hospital, London, UK.
To compare V kappa gene usage and the amount of somatic mutation in
rearranged Ig genes from patients with lymphoproliferative disorders, we
have polymerase chain reaction-amplified and sequenced a total of 26 V
kappa genes from a total of 55 cases. Six sequences were obtained both from
six cases of prolymphocytic leukemia (PLL) and from nine cases of hairy
cell leukemia (HCL). Seven sequences were obtained both from 11 cases of
Waldenstrom's macroglobulinemia (WM) and 29 cases of multiple myeloma (MM).
Eleven different germline genes have been used in this series, indicating a
wide but nonrandom usage of germline Ig gene rearrangements in these
disorders. Comparison of the nucleotide sequences of V kappa genes obtained
from B-cell malignancies with germline V kappa genes shows that somatic
mutation is rare in PLL and HCL and common in WM and MM. Analysis of the
pattern of mutations suggests that WM and MM are derived from B cells that
have been selected by antigen at a relatively late stage of
differentiation.
Volume 83,
Issue 12,
pp. 3647-3653,
06/15/1994
Copyright © 1994 by The American Society of Hematology
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