|
|
 Previous Article | Table of Contents | Next Article 
Similar patterns of V kappa gene usage but different degrees of somatic
mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's
macroglobulinemia, and myeloma
SD Wagner, V Martinelli and L Luzzatto
Department of Haematology, Royal Postgraduate Medical School, Hammersmith
Hospital, London, UK.
To compare V kappa gene usage and the amount of somatic mutation in
rearranged Ig genes from patients with lymphoproliferative disorders, we
have polymerase chain reaction-amplified and sequenced a total of 26 V
kappa genes from a total of 55 cases. Six sequences were obtained both from
six cases of prolymphocytic leukemia (PLL) and from nine cases of hairy
cell leukemia (HCL). Seven sequences were obtained both from 11 cases of
Waldenstrom's macroglobulinemia (WM) and 29 cases of multiple myeloma (MM).
Eleven different germline genes have been used in this series, indicating a
wide but nonrandom usage of germline Ig gene rearrangements in these
disorders. Comparison of the nucleotide sequences of V kappa genes obtained
from B-cell malignancies with germline V kappa genes shows that somatic
mutation is rare in PLL and HCL and common in WM and MM. Analysis of the
pattern of mutations suggests that WM and MM are derived from B cells that
have been selected by antigen at a relatively late stage of
differentiation.
Volume 83,
Issue 12,
pp. 3647-3653,
06/15/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. Koshiol, G. Gridley, E. A. Engels, M. L. McMaster, and O. Landgren
Chronic Immune Stimulation and Subsequent Waldenstrom Macroglobulinemia
Arch Intern Med,
September 22, 2008;
168(17):
1903 - 1909.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Gonzalez, M. van der Burg, R. Garcia-Sanz, J. A. Fenton, A. W. Langerak, M. Gonzalez, J. J. M. van Dongen, J. F. San Miguel, and G. J. Morgan
Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma
Blood,
November 1, 2007;
110(9):
3112 - 3121.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Kriangkum, B. J. Taylor, S. P. Treon, M. J. Mant, A. R. Belch, and L. M. Pilarski
Clonotypic IgM V/D/J sequence analysis in Waldenstrom macroglobulinemia suggests an unusual B-cell origin and an expansion of polyclonal B cells in peripheral blood
Blood,
October 1, 2004;
104(7):
2134 - 2142.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Gertz, G. Merlini, and S. P. Treon
Amyloidosis and Waldenstrom's Macroglobulinemia
Hematology,
January 1, 2004;
2004(1):
257 - 282.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Tanioka, S. Tamashima, S.-i. Shimizu, H. Kobayashi, Y. Kobayashi, and H. Sugimura
A Case of Primary Plasma Cell Leukemia with Hairy-cell Morphology and Lambda-type Bence-Jones Protein. Immunohistochemical and Molecular Analysis
Jpn. J. Clin. Oncol.,
May 1, 2003;
33(5):
232 - 237.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Sahota, F. Forconi, C. H. Ottensmeier, D. Provan, D. G. Oscier, T. J. Hamblin, and F. K. Stevenson
Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events
Blood,
July 30, 2002;
100(4):
1505 - 1507.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Ciric, V. VanKeulen, M. Rodriguez, R. A. Kyle, M. A. Gertz, and L. R. Pease
Clonal evolution in Waldenstrom macroglobulinemia highlights functional role of B-cell receptor
Blood,
January 1, 2001;
97(1):
321 - 323.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Capello, U. Vitolo, L. Pasqualucci, S. Quattrone, G. Migliaretti, L. Fassone, C. Ariatti, D. Vivenza, A. Gloghini, C. Pastore, et al.
Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia
Blood,
January 15, 2000;
95(2):
651 - 659.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Dimopoulos, P. Panayiotidis, L. A. Moulopoulos, P. Sfikakis, and M. Dalakas
Waldenstrom’s Macroglobulinemia: Clinical Features, Complications, and Management
J. Clin. Oncol.,
January 5, 2000;
18(1):
214 - 214.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Kuppers, U. Klein, M.-L. Hansmann, and K. Rajewsky
Cellular Origin of Human B-Cell Lymphomas
N. Engl. J. Med.,
November 11, 1999;
341(20):
1520 - 1529.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Z. Gong, S. Zheng, R. Chiarle, C. De Wolf-Peeters, G. Palestro, G. Frizzera, and G. Inghirami
Detection of Immunoglobulin {kappa} Light Chain Rearrangements by Polymerase Chain Reaction : An Improved Method for Detecting Clonal B-CellLymphoproliferative Disorders
Am. J. Pathol.,
August 1, 1999;
155(2):
355 - 363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Sahota, R. Garand, R. Mahroof, A. Smith, N. Juge-Morineau, F. K. Stevenson, and R. Bataille
VH Gene Analysis of IgM-Secreting Myeloma Indicates an Origin From a Memory Cell Undergoing Isotype Switch Events
Blood,
August 1, 1999;
94(3):
1070 - 1076.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. T. Messmer, J. J. Sullivan, N. Chiorazzi, T. C. Rodman, and D. S. Thaler
Two Human Neonatal IgM Antibodies Encoded by Different Variable-Region Genes Bind the Same Linear Peptide: Evidence for a Stereotyped Repertoire of Epitope Recognition
J. Immunol.,
February 15, 1999;
162(4):
2184 - 2192.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Dorfman, A. Shahsafaei, L. M. Nadler, and G. J. Freeman
The Leukocyte Semaphorin CD100 Is Expressed in Most T-Cell, but Few B-Cell, Non-Hodgkin's Lymphomas
Am. J. Pathol.,
July 1, 1998;
153(1):
255 - 262.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Arpin, O. de Bouteiller, D. Razanajaona, I. Fugier-Vivier, F. Briere, J. Banchereau, S. Lebecque, and Y.-J. Liu
The Normal Counterpart of IgD Myeloma Cells in Germinal Center Displays Extensively Mutated IgVH Gene, Cµ-Cdelta Switch, and lambda Light Chain Expression
J. Exp. Med.,
April 20, 1998;
187(8):
1169 - 1178.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ivanovski, F. Silvestri, G. Pozzato, S. Anand, C. Mazzaro, O. R. Burrone, and D. G. Efremov
Somatic Hypermutation, Clonal Diversity, and Preferential Expression of the VH 51p1/VL kv325 Immunoglobulin Gene Combination in Hepatitis C Virus-Associated Immunocytomas
Blood,
April 1, 1998;
91(7):
2433 - 2442.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Sahota, R. Garand, R. Bataille, A. J. Smith, and F. K. Stevenson
VH Gene Analysis of Clonally Related IgM and IgG From Human Lymphoplasmacytoid B-Cell Tumors With Chronic Lymphocytic Leukemia Features and High Serum Monoclonal IgG
Blood,
January 1, 1998;
91(1):
238 - 243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Kosmas, K. Stamatopoulos, D. Loukopoulos;, F. K. Stevenson, and S.S. Sahota
Antigen Selection of Multiple Myeloma Clonogenic B Cells as Evidenced by VH and VL Gene Mutations
Blood,
August 1, 1997;
90(3):
1334 - 1334.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Sahota, R. Leo, T. J. Hamblin, and F. K. Stevenson
Myeloma VL and VH Gene Sequences Reveal a Complementary Imprint of Antigen Selection in Tumor Cells
Blood,
January 1, 1997;
89(1):
219 - 226.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
