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Oligoclonal expansion of CD8+ CD57+ T cells with restricted T-cell receptor
beta chain variability after bone marrow transplantation
G Gorochov, P Debre, V Leblond, B Sadat-Sowti, F Sigaux and B Autran
Laboratoire d'Hematologie Moleculaire, Hopital Saint-Louis, Paris, France.
A major expansion of CD8+57+ lymphocytes expressing an alpha-beta T- cell
receptor (TCR) is frequent after bone marrow transplantation (BMT). We
examined the clonality of the TCR beta gene repertoire in these expanded
CD8+57+ cells after allogeneic or autologous BMT. We performed a polymerase
chain reaction (PCR) analysis of the V beta chain usage in CD8+57+ cells
purified from nine BMT recipients with a series of oligonucleotides
specific for 20 V beta gene families. PCR products from selected TCR beta
gene rearrangements were sequenced. The CD8+57+ cells from eight of nine
patients used a restricted set of V beta families, with a marked
predominance of two to three V beta gene families per patient, whereas the
control autologous CD57- subset expressed the whole 20 V beta families. A
direct sequencing analysis confirmed the V beta 16 and V beta 17 clonality
in six patients, showing a striking homology in the CDR3 sequences of the V
beta 16 products. The CD8+57+ cells, but not the CD57- cells, displayed an
oligoclonal pattern of TCR rearrangements as shown by PCR analysis of TCR
gamma gene rearrangements. Such an oligoclonal expansion of CD8+57+ cells,
using a restricted set of the V beta gene families, may result from a
specific TCR stimulation of a limited number of T-cell clones in BMT
recipients.
Volume 83,
Issue 2,
pp. 587-595,
01/15/1994
Copyright © 1994 by The American Society of Hematology
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