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Recognition of minor histocompatibility antigens on lymphocytic and myeloid
leukemic cells by cytotoxic T-cell clones
D van der Harst, E Goulmy, JH Falkenburg, YM Kooij-Winkelaar, SA van Luxemburg- Heijs, HM Goselink and A Brand
Department of Immunohematology and Bloodbank, University Medical Center,
Leiden, The Netherlands.
Clinical studies indicated an enhanced antileukemic effect of allogeneic
bone marrow transplantation (BMT), as compared with autologous BMT. After
allogeneic HLA-identical BMT, donor-derived cytotoxic T lymphocytes (CTLs)
directed at minor histocompatibility (mH) antigens on the recipients,
tissues can be shown. To evaluate the antileukemic reactivity of mH
antigen-specific CTLs, we analyzed the expression of mH antigens on
circulating lymphocytic and myeloid leukemic cells. We show that the
defined mH specificities HA-1 through HA-5 and H-Y are present on leukemic
cells, indicating that mH antigen- specific CTLs are capable of HLA class
I-restricted antigen-specific lysis of leukemic cells. Compared with
interleukin-2-stimulated normal lymphocytes, leukemic cells of lymphocytic
origin are less susceptible to T-cell-mediated cytotoxicity by the HA-2 mH
antigen-specific CTL and the anti-HLA-A2 CTL clone. A possible explanation
for this phenomenon is impaired expression of the LFA-1 adhesion molecule.
Our study suggests that mH antigen-specific HLA class I-restricted CD8+
CTLs may be involved in the graft-versus-leukemia reactivity after
allogeneic BMT.
Volume 83,
Issue 4,
pp. 1060-1066,
02/15/1994
Copyright © 1994 by The American Society of Hematology
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