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IgMs produced by two acquired immune deficiency syndrome lymphoma cell
lines: Ig binding specificity and VH-gene putative somatic mutation
analysis [published erratum appears in Blood 1994 Aug 1;84(3):995]
VL Ng, MH Hurt, CL Fein, F Khayam-Bashi, J Marsh, WM Nunes, LW McPhaul, E Feigal, P Nelson and BG Herndier
Department of Laboratory Medicine, School of Medicine, University of
California, San Francisco.
Two B-cell lines, 2F7 and 10C9, were established by single cell cloning
from biopsies obtained from two acquired immune deficiency syndrome
patients with Burkitt's lymphoma. Representation of the original tumors was
verified by demonstration of (1) identical biallelic rearrangement of Ig
genes for 2F7 and (2) shared idiotype for 10C9. Both cell lines displayed
cell-surface Ig and secreted Ig (IgM lambda for 2F7, IgM kappa for 10C9).
IgMs from both cell lines immunoprecipitated actin; in addition, 2F7 IgM
lambda immunoprecipitated recombinant human immunodeficiency virus type 1
(HIV-1) gp 160. 2F7 IgM lambda did not react with other autoantigens
(double-stranded and single-stranded DNA, actin, bovine serum albumin,
IgG), whereas 10C9 IgM kappa reacted with human IgG. The 2F7 IgM
heavy-chain variable region (VH) showed a 95% nucleotide homology with a
previously sequenced VHIII germline gene, hv3019b9, whereas the 10C9 IgM VH
showed a 95% homology with a previously sequenced VHIV germline gene,
VH4.21. Use of minimally modified VH genes and demonstration of reactivity
with chronically present antigens (ie, actin, HIV-1 gp 160, or human IgG)
suggests that B cells in HIV-1-infected individuals proliferating in
response to chronic antigenic stimulation may be at increased risk for
lymphomagenesis.
Volume 83,
Issue 4,
pp. 1067-1078,
02/15/1994
Copyright © 1994 by The American Society of Hematology
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