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Transmission of maternal blood cells to the fetus during pregnancy:
detection in mouse neonatal spleen by immunofluorescence flow cytometry and
polymerase chain reaction
M Shimamura, S Ohta, R Suzuki and K Yamazaki
Laboratory of Molecular Immunology, Mitsubishi Kasei Institute of Life
Sciences, Tokyo, Japan.
Mouse embryos were transferred to allogeneic pseudopregnant foster mothers
and the cells of the resultant neonates were analyzed for the expression of
maternal major histocompatibility complex (MHC) antigens to elucidate
maternal cell transmission to the fetus during pregnancy. Expression of
maternal-type MHC antigens was detected in the spleen but not in the liver
or thymus of the neonates in analyses by immunofluorescence flow cytometry
and polymerase chain reaction. These findings provide evidence, on the
molecular basis, that maternal blood cells are transmitted to the fetus
through the placenta.
Volume 83,
Issue 4,
pp. 926-930,
02/15/1994
Copyright © 1994 by The American Society of Hematology
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