|
 Previous Article | Table of Contents | Next Article 
Induced expression of c-fms in normal hematopoietic cells shows evidence
for both conservation and lineage restriction of signal transduction in
response to macrophage colony-stimulating factor
GA McArthur, LR Rohrschneider and GR Johnson
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne
Hospital, Victoria, Australia.
Retrovirus-mediated gene transfer was used to obtain expression of the
macrophage colony-stimulating factor (MCSF) receptor, c-fms, on
hematopoietic lineages that normally do not express this receptor. Cultures
of murine fetal liver cells infected with the c-fms retrovirus developed
erythroid colonies in cultures stimulated with M-CSF. However, these
colonies were fewer and less hemoglobinized than colonies in parallel
cultures stimulated by erythropoietin. Culture of isolated clones
demonstrated a direct action of M-CSF on erythroid clones. Culture of c-fms
retrovirus-infected adult murine bone marrow cells showed megakaryocyte and
novel macrophage-megakaryocyte clones when stimulated by M-CSF. Culture of
isolated clones again confirmed a direct action of M-CSF on megakaryocyte
clones. In contrast, M-CSF stimulation of c-fms-infected granulocytes and
granulocyte progenitor cells did not elicit proliferation, enhanced
survival, or functional stimulation of granulocytes. These findings provide
evidence for both conservation and lineage restriction of signal
transduction in normal hematopoietic cells.
Volume 83,
Issue 4,
pp. 972-981,
02/15/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. Brisken, M. Socolovsky, H. F. Lodish, and R. Weinberg
The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium
PNAS,
October 29, 2002;
99(22):
14241 - 14245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.D. Cashman, I. Clark-Lewis, A.C. Eaves, and C.J. Eaves
Differentiation Stage-Specific Regulation of Primitive Human Hematopoietic Progenitor Cycling by Exogenous and Endogenous Inhibitors in an In Vivo Model
Blood,
December 1, 1999;
94(11):
3722 - 3729.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. METCALF
Stem Cells, Pre-Progenitor Cells and Lineage-Committed Cells: Are Our Dogmas Correct?
Ann. N.Y. Acad. Sci.,
April 30, 1999;
872(1):
289 - 304.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Jacob, J. S. Haug, S. Raptis, and D. C. Link
Specific Signals Generated by the Cytoplasmic Domain of the Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Not Required for G-CSF-Dependent Granulocytic Differentiation
Blood,
July 15, 1998;
92(2):
353 - 361.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Metcalf
Lineage Commitment and Maturation in Hematopoietic Cells: The Case for Extrinsic Regulation
Blood,
July 15, 1998;
92(2):
345 - 347.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Socolovsky, H. F. Lodish, and G. Q. Daley
Control of hematopoietic differentiation: Lack of specificity in signaling by cytokine receptors
PNAS,
June 9, 1998;
95(12):
6573 - 6575.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Goldsmith, A. Mikami, Y. You, K. D. Liu, L. Thomas, P. Pharr, and G. D. Longmore
Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo
PNAS,
June 9, 1998;
95(12):
7006 - 7011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Socolovsky, I. Dusanter-Fourt, and H. F. Lodish
The Prolactin Receptor and Severely Truncated Erythropoietin Receptors Support Differentiation of Erythroid Progenitors
J. Biol. Chem.,
May 30, 1997;
272(22):
14009 - 14012.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
