|
 Previous Article | Table of Contents | Next Article 
DNA rearrangements proximal to the EVI1 locus associated with the 3q21q26
syndrome
ER Levy, E Parganas, K Morishita, S Fichelson, L James, D Oscier, S Gisselbrecht, JN Ihle and VJ Buckle
Molecular Haematology Unit, John Radcliffe Hospital, Oxford, UK.
Specific rearrangements involving 3q21 and 3q26 are well documented in
acute myeloid leukemia (AML). Aberrant expression of the Ecotropic virus
integration-1 (EVI1) gene, located at 3q26, has been reported in
individuals with AML and translocations or inversions of chromosome 3 long
arm. We have studied six individuals with AML and inv(3)(q21q26) for
disruptions to the EVI1 locus by in situ hybridization and long- range
mapping. EVI1 transcripts have been detected in the blast cells of the two
individuals available for expression studies. We derived a YAC containing
the EVI1 gene and showed that it crossed the 3q26 inversion breakpoints in
three of four cases examined. Pulsed field analysis detected aberrant
fragments 3' of the EVI1 gene in all six patients. The orientation of the
gene was established and the locations of the breakpoints were refined by
in situ hybridization using phage clones from this region.
Volume 83,
Issue 5,
pp. 1348-1354,
03/01/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
G. Jin, Y. Yamazaki, M. Takuwa, T. Takahara, K. Kaneko, T. Kuwata, S. Miyata, and T. Nakamura
Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis
Blood,
May 1, 2007;
109(9):
3998 - 4005.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. Boyd, Y.-Y. Xiao, K. Fan, A. Poholek, N. G. Copeland, N. A. Jenkins, and A. S. Perkins
Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR
Blood,
January 15, 2006;
107(2):
733 - 741.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Cools, N. Mentens, M. D. Odero, P. Peeters, I. Wlodarska, M. Delforge, A. Hagemeijer, and P. Marynen
Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13)
Blood,
March 1, 2002;
99(5):
1776 - 1784.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kurokawa, K. Mitani, Y. Imai, S. Ogawa, Y. Yazaki, and H. Hirai
The t(3;21) Fusion Product, AML1/Evi-1, Interacts With Smad3 and Blocks Transforming Growth Factor-beta -Mediated Growth Inhibition of Myeloid Cells
Blood,
December 1, 1998;
92(11):
4003 - 4012.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Perkins and J. H. Kim
Zinc Fingers 1-7 of EVI1 Fail to Bind to the GATA Motif by Itself but Require the Core Site GACAAGATA for Binding
J. Biol. Chem.,
January 12, 1996;
271(2):
1104 - 1110.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
