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The function of c-fms in hairy-cell leukemia: macrophage colony-
stimulating factor stimulates hairy-cell movement
J Burthem, PK Baker, JA Hunt and JC Cawley
Department of Haematology, University of Liverpool, UK.
Hairy cells (HCs) and some activated B cells express high levels of
macrophage colony-stimulating factor (M-CSF) (CSF-1) receptor, but the
functional effects of the cytokine on B cells have not been previously
identified. Using video microscopy, image analysis, and migration assays,
M-CSF was shown to induce chemokinetic and chemotactic movement of HCs.
This movement response involved transition to a highly mobile, rounded cell
form and was accompanied by distinctive changes in F-actin polymerization
and distribution. Furthermore, the M-CSF-induced motility was substantially
modified by the adhesive protein used as a substratum and involved
qualitative changes in the function of the alpha v beta 3 integrin of HCs.
It is suggested that the findings are relevant to the pathophysiology of
hairy-cell leukemia (HCL) in particular, and to the biology of B-cell
migration in general.
Volume 83,
Issue 5,
pp. 1381-1389,
03/01/1994
Copyright © 1994 by The American Society of Hematology
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