SEARCH:   Advanced

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bedi, A Articles by Jones, R. Search for Related Content PubMed PubMed Citation Articles by Bedi, A Articles by Jones, R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia A Bedi, BA Zehnbauer, JP Barber, SJ Sharkis and RJ Jones Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, MD 21287-8967. BCR-ABL expression is presumed to effect clonal expansion in chronic myeloid leukemia (CML) by deregulation of cell proliferation. However, most studies have found that relative rates of cell proliferation are not increased in CML. Moreover, we found that CML progenitors display a normal proliferative response to growth factors and do not manifest greater proliferative potential than normal progenitors. Growth of malignancies depends on an imbalance between the rate of cell production and the rate of cell death. We found that BCR-ABL expression inappropriately prolongs the growth factor-independent survival of CML myeloid progenitors and granulocytes by inhibiting apoptosis, a genetically programmed process of active cell death; inhibition of BCR- ABL expression by antisense oligonucleotides reversed the suppression of apoptosis as well as the enhancement of survival. The decreased rate of programmed cell death appears to be the primary mechanism by which BCR-ABL effects expansion of the leukemic clone in CML. Volume 83, Issue 8, pp. 2038-2044, 04/15/1994 Copyright © 1994 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. H. Kim, W. Xu, C. Ma, X. Liu, K. Siminovitch, H. A. Messner, and J. H. Lipton Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia Blood, March 12, 2009; 113(11): 2517 - 2525. [Abstract] [Full Text] [PDF] X. Shi, Y. Jin, C. Cheng, H. Zhang, W. Zou, Q. Zheng, Z. Lu, Q. Chen, Y. Lai, and J. Pan Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation Clin. Cancer Res., March 1, 2009; 15(5): 1686 - 1697. [Abstract] [Full Text] [PDF] Y. Dai, S. Chen, C. A. Venditti, X.-Y. Pei, T. K. Nguyen, P. Dent, and S. Grant Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate Blood, August 1, 2008; 112(3): 793 - 804. [Abstract] [Full Text] [PDF] E. Kavalerchik, D. Goff, and C. H.M. Jamieson Chronic Myeloid Leukemia Stem Cells J. Clin. Oncol., June 10, 2008; 26(17): 2911 - 2915. [Abstract] [Full Text] [PDF] M. Copland, F. Pellicano, L. Richmond, E. K. Allan, A. Hamilton, F. Y. Lee, R. Weinmann, and T. L. Holyoake BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors Blood, March 1, 2008; 111(5): 2843 - 2853. [Abstract] [Full Text] [PDF] M. Mayerhofer, K. V. Gleixner, J. Mayerhofer, G. Hoermann, E. Jaeger, K. J. Aichberger, R. G. Ott, K. Greish, H. Nakamura, S. Derdak, et al. Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib Blood, February 15, 2008; 111(4): 2200 - 2210. [Abstract] [Full Text] [PDF] J. Lee, Y. Kim, J. Lim, M. Kim, and K. Han G-CSF and GM-CSF Concentrations and Receptor Expression in Peripheral Blood Leukemic Cells from Patients with Chronic Myelogenous Leukemia Ann. Clin. Lab. Sci., January 1, 2008; 38(4): 331 - 337. [Abstract] [Full Text] [PDF] C. H. Jamieson Chronic Myeloid Leukemia Stem Cells Hematology, January 1, 2008; 2008(1): 436 - 442. [Abstract] [Full Text] [PDF] P. La Rosee, T. Jia, S. Demehri, N. Hartel, P. de Vries, L. Bonham, D. Hollenback, J. W. Singer, J. V. Melo, B. J. Druker, et al. Antileukemic Activity of Lysophosphatidic Acid Acyltransferase-{beta} Inhibitor CT32228 in Chronic Myelogenous Leukemia Sensitive and Resistant to Imatinib. Clin. Cancer Res., November 1, 2006; 12(21): 6540 - 6546. [Abstract] [Full Text] [PDF] X. Ma, G. Ruan, Y. Wang, Q. Li, P. Zhu, Y.-Z. Qin, J.-L. Li, Y.-R. Liu, D. Ma, and H. Zhao Two Single-Nucleotide Polymorphisms with Linkage Disequilibrium in the Human Programmed Cell Death 5 Gene 5' Regulatory Region Affect Promoter Activity and the Susceptibility of Chronic Myelogenous Leukemia in Chinese Population Clin. Cancer Res., December 15, 2005; 11(24): 8592 - 8599. [Abstract] [Full Text] [PDF] K. J. Aichberger, M. Mayerhofer, M.-T. Krauth, A. Vales, R. Kondo, S. Derdak, W. F. Pickl, E. Selzer, M. Deininger, B. J. Druker, et al. Low-Level Expression of Proapoptotic Bcl-2-Interacting Mediator in Leukemic Cells in Patients with Chronic Myeloid Leukemia: Role of BCR/ABL, Characterization of Underlying Signaling Pathways, and Reexpression by Novel Pharmacologic Compounds Cancer Res., October 15, 2005; 65(20): 9436 - 9444. [Abstract] [Full Text] [PDF] F. B. Hickey, K. England, and T. G. Cotter Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1, and MEK J. Leukoc. Biol., July 1, 2005; 78(1): 289 - 300. [Abstract] [Full Text] [PDF] E. J. Andreu, E. Lledo, E. Poch, C. Ivorra, M. P. Albero, J. A. Martinez-Climent, C. Montiel-Duarte, J. Rifon, J. Perez-Calvo, C. Arbona, et al. BCR-ABL Induces the Expression of Skp2 through the PI3K Pathway to Promote p27Kip1 Degradation and Proliferation of Chronic Myelogenous Leukemia Cells Cancer Res., April 15, 2005; 65(8): 3264 - 3272. [Abstract] [Full Text] [PDF] K. J. Aichberger, M. Mayerhofer, M.-T. Krauth, H. Skvara, S. Florian, K. Sonneck, C. Akgul, S. Derdak, W. F. Pickl, V. Wacheck, et al. Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides Blood, April 15, 2005; 105(8): 3303 - 3311. [Abstract] [Full Text] [PDF] M. Deininger, E. Buchdunger, and B. J. Druker The development of imatinib as a therapeutic agent for chronic myeloid leukemia Blood, April 1, 2005; 105(7): 2640 - 2653. [Abstract] [Full Text] [PDF] P. B. Deming, Z. T. Schafer, J. S. Tashker, M. B. Potts, M. Deshmukh, and S. Kornbluth Bcr-Abl-Mediated Protection from Apoptosis Downstream of Mitochondrial Cytochrome c Release Mol. Cell. Biol., December 1, 2004; 24(23): 10289 - 10299. [Abstract] [Full Text] [PDF] P. Ramaraj, H. Singh, N. Niu, S. Chu, M. Holtz, J. K. Yee, and R. Bhatia Effect of Mutational Inactivation of Tyrosine Kinase Activity on BCR/ABL-Induced Abnormalities in Cell Growth and Adhesion in Human Hematopoietic Progenitors Cancer Res., August 1, 2004; 64(15): 5322 - 5331. [Abstract] [Full Text] [PDF] N. Ajenjo, E. Canon, I. Sanchez-Perez, D. Matallanas, J. Leon, R. Perona, and P. Crespo Subcellular Localization Determines the Protective Effects of Activated ERK2 against Distinct Apoptogenic Stimuli in Myeloid Leukemia Cells J. Biol. Chem., July 30, 2004; 279(31): 32813 - 32823. [Abstract] [Full Text] [PDF] R. Kuribara, H. Honda, H. Matsui, T. Shinjyo, T. Inukai, K. Sugita, S. Nakazawa, H. Hirai, K. Ozawa, and T. Inaba Roles of Bim in Apoptosis of Normal and Bcr-Abl-Expressing Hematopoietic Progenitors Mol. Cell. Biol., July 15, 2004; 24(14): 6172 - 6183. [Abstract] [Full Text] [PDF] B. Calabretta and D. Perrotti The biology of CML blast crisis Blood, June 1, 2004; 103(11): 4010 - 4022. [Abstract] [Full Text] [PDF] M. Mayerhofer, S. Florian, M.-T. Krauth, K. J. Aichberger, M. Bilban, R. Marculescu, D. Printz, G. Fritsch, O. Wagner, E. Selzer, et al. Identification of Heme Oxygenase-1 As a Novel BCR/ABL-Dependent Survival Factor in Chronic Myeloid Leukemia Cancer Res., May 1, 2004; 64(9): 3148 - 3154. [Abstract] [Full Text] [PDF] W. Matsui, C. A. Huff, Q. Wang, M. T. Malehorn, J. Barber, Y. Tanhehco, B. D. Smith, C. I. Civin, and R. J. Jones Characterization of clonogenic multiple myeloma cells Blood, March 15, 2004; 103(6): 2332 - 2336. [Abstract] [Full Text] [PDF] F. E. Ouriaghli, E. Sloand, L. Mainwaring, H. Fujiwara, K. Keyvanfar, J. J. Melenhorst, K. Rezvani, G. Sconocchia, S. Solomon, N. Hensel, et al. Clonal dominance of chronic myelogenous leukemia is associated with diminished sensitivity to the antiproliferative effects of neutrophil elastase Blood, November 15, 2003; 102(10): 3786 - 3792. [Abstract] [Full Text] [PDF] J. M. Goldman and J. V. Melo Chronic Myeloid Leukemia -- Advances in Biology and New Approaches to Treatment N. Engl. J. Med., October 9, 2003; 349(15): 1451 - 1464. [Full Text] [PDF] M. W. N. Deininger and B. J. Druker Specific Targeted Therapy of Chronic Myelogenous Leukemia with Imatinib Pharmacol. Rev., September 1, 2003; 55(3): 401 - 423. [Abstract] [Full Text] [PDF] R. Kurzrock, H. M. Kantarjian, B. J. Druker, and M. Talpaz Philadelphia Chromosome-Positive Leukemias: From Basic Mechanisms to Molecular Therapeutics Ann Intern Med, May 20, 2003; 138(10): 819 - 830. [Abstract] [Full Text] [PDF] S. Wong, J. McLaughlin, D. Cheng, and O. N. Witte Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors Blood, May 15, 2003; 101(10): 4088 - 4097. [Abstract] [Full Text] [PDF] J. Roman-Gomez, J. A. Castillejo, A. Jimenez, F. Cervantes, C. Boque, L. Hermosin, A. Leon, A. Granena, D. Colomer, A. Heiniger, et al. Cadherin-13, a Mediator of Calcium-Dependent Cell-Cell Adhesion, Is Silenced by Methylation in Chronic Myeloid Leukemia and Correlates With Pretreatment Risk Profile and Cytogenetic Response to Interferon Alfa J. Clin. Oncol., April 15, 2003; 21(8): 1472 - 1479. [Abstract] [Full Text] [PDF] N. Komatsu, T. Watanabe, M. Uchida, M. Mori, K. Kirito, S. Kikuchi, Q. Liu, T. Tauchi, K. Miyazawa, H. Endo, et al. A Member of Forkhead Transcription Factor FKHRL1 Is a Downstream Effector of STI571-induced Cell Cycle Arrest in BCR-ABL-expressing Cells J. Biol. Chem., February 14, 2003; 278(8): 6411 - 6419. [Abstract] [Full Text] [PDF] S. Salesse and C. M. Verfaillie BCR/ABL-mediated Increased Expression of Multiple Known and Novel Genes That May Contribute to the Pathogenesis of Chronic Myelogenous Leukemia Mol. Cancer Ther., February 1, 2003; 2(2): 173 - 182. [Abstract] [Full Text] [PDF] M. Mayerhofer, P. Valent, W. R. Sperr, J. D. Griffin, and C. Sillaber BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha , through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin Blood, November 15, 2002; 100(10): 3767 - 3775. [Abstract] [Full Text] [PDF] M. S. Holtz, M. L. Slovak, F. Zhang, C. L. Sawyers, S. J. Forman, and R. Bhatia Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation Blood, May 15, 2002; 99(10): 3792 - 3800. [Abstract] [Full Text] [PDF] B. Glei{beta}ner, N. Gokbuget, C. R. Bartram, B. Janssen, H. Rieder, J. W. G. Janssen, C. Fonatsch, A. Heyll, D. Voliotis, J. Beck, et al. Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis Blood, March 1, 2002; 99(5): 1536 - 1543. [Abstract] [Full Text] [PDF] D. G. Savage and K. H. Antman Imatinib Mesylate -- A New Oral Targeted Therapy N. Engl. J. Med., February 28, 2002; 346(9): 683 - 693. [Full Text] [PDF] S. N. Rylova, A. Amalfitano, D.-A. Persaud-Sawin, W.-X. Guo, J. Chang, P. J. Jansen, A. D. Proia, and R.-M. Boustany The CLN3 Gene is a Novel Molecular Target for Cancer Drug Discovery Cancer Res., February 1, 2002; 62(3): 801 - 808. [Abstract] [Full Text] [PDF] B. M. F. Mow, J. Chandra, P. A. Svingen, C. G. Hallgren, E. Weisberg, T. J. Kottke, V. L. Narayanan, M. R. Litzow, J. D. Griffin, E. A. Sausville, et al. Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro Blood, January 15, 2002; 99(2): 664 - 671. [Abstract] [Full Text] [PDF] M. J. Mauro, M. O'Dwyer, M. C. Heinrich, and B. J. Druker STI571: A Paradigm of New Agents for Cancer Therapeutics J. Clin. Oncol., January 1, 2002; 20(1): 325 - 334. [Abstract] [Full Text] [PDF] N. Hawk, T. Sun, S. Xie, Y. Wang, Y. Wu, J. Liu, and R. B. Arlinghaus Inhibition of the Bcr-Abl Oncoprotein by Bcr Requires Phosphoserine 354 Cancer Res., January 1, 2002; 62(2): 386 - 390. [Abstract] [Full Text] [PDF] N. Jena, M. Deng, E. Sicinska, P. Sicinski, and G. Q. Daley Critical Role for Cyclin D2 in BCR/ABL-induced Proliferation of Hematopoietic Cells Cancer Res., January 1, 2002; 62(2): 535 - 541. [Abstract] [Full Text] [PDF] S. M. Graham, H. G. Jorgensen, E. Allan, C. Pearson, M. J. Alcorn, L. Richmond, and T. L. Holyoake Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro Blood, January 1, 2002; 99(1): 319 - 325. [Abstract] [Full Text] [PDF] A. W. Goetz, H. van der Kuip, R. Maya, M. Oren, and W. E. Aulitzky Requirement for Mdm2 in the Survival Effects of Bcr-Abl and Interleukin 3 in Hematopoietic Cells Cancer Res., October 1, 2001; 61(20): 7635 - 7641. [Abstract] [Full Text] [PDF] H. van der Kuip, A. W. Goetz, C. Miething, J. Duyster, and W. E. Aulitzky Adhesion to fibronectin selectively protects Bcr-Abl+ cells from DNA damage-induced apoptosis Blood, September 1, 2001; 98(5): 1532 - 1541. [Abstract] [Full Text] [PDF] A. Di Cristofano, M. Niki, M. Zhao, F. G. Karnell, B. Clarkson, W. S. Pear, L. Van Aelst, and P. P. Pandolfi P62dok, a Negative Regulator of Ras and Mitogen-Activated Protein Kinase (Mapk) Activity, Opposes Leukemogenesis by P210bcr-abl J. Exp. Med., August 6, 2001; 194(3): 275 - 284. [Abstract] [Full Text] [PDF] R. C. Zhao, Y. Jiang, and C. M. Verfaillie A model of human p210bcr/ABL-mediated chronic myelogenous leukemia by transduction of primary normal human CD34+ cells with a BCR/ABL-containing retroviral vector Blood, April 15, 2001; 97(8): 2406 - 2412. [Abstract] [Full Text] [PDF] K. Okuda, E. Weisberg, D. G. Gilliland, and J. D. Griffin ARG tyrosine kinase activity is inhibited by STI571 Blood, April 15, 2001; 97(8): 2440 - 2448. [Abstract] [Full Text] [PDF] F. Prosper and C. M. Verfaillie Regulation of hematopoiesis through adhesion receptors J. Leukoc. Biol., March 1, 2001; 69(3): 307 - 316. [Abstract] [Full Text] T. L. Holyoake, X. Jiang, H. G. Jorgensen, S. Graham, M. J. Alcorn, C. Laird, A. C. Eaves, and C. J. Eaves Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3 Blood, February 1, 2001; 97(3): 720 - 728. [Abstract] [Full Text] [PDF] M. W. N. Deininger, J. M. Goldman, and J. V. Melo The molecular biology of chronic myeloid leukemia Blood, November 15, 2000; 96(10): 3343 - 3356. [Full Text] [PDF] J. T. Thiesing, S. Ohno-Jones, K. S. Kolibaba, and B. J. Druker Efficacy of STI571, an Abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against Bcr-Abl-positive cells Blood, November 1, 2000; 96(9): 3195 - 3199. [Abstract] [Full Text] [PDF] F. Gesbert and J. D. Griffin Bcr/Abl activates transcription of the Bcl-X gene through STAT5 Blood, September 15, 2000; 96(6): 2269 - 2276. [Abstract] [Full Text] [PDF] T. Jonuleit, H. van der Kuip, C. Miething, H. Michels, M. Hallek, J. Duyster, and W. E. Aulitzky Bcr-Abl kinase down-regulates cyclin-dependent kinase inhibitor p27 in human and murine cell lines Blood, September 1, 2000; 96(5): 1933 - 1939. [Abstract] [Full Text] [PDF] T. Stiewe, K. Parssanedjad, H. Esche, B. Opalka, and B. M. Pützer E1A Overcomes the Apoptosis Block in BCR-ABL+ Leukemia Cells and Renders Cells Susceptible to Induction of Apoptosis by Chemotherapeutic Agents Cancer Res., July 1, 2000; 60(14): 3957 - 3964. [Abstract] [Full Text] T. Kuwata, I-M. Wang, T. Tamura, R. M. Ponnamperuma, R. Levine, K. L. Holmes, H. C. Morse III, L. M. De Luca, and K. Ozato Vitamin A deficiency in mice causes a systemic expansion of myeloid cells Blood, June 1, 2000; 95(11): 3349 - 3356. [Abstract] [Full Text] [PDF] X. Tang, C. P. Downes, A. D. Whetton, and P. J. Owen-Lynch Role of Phosphatidylinositol 3-Kinase and Specific Protein Kinase B Isoforms in the Suppression of Apoptosis Mediated by the Abelson Protein-tyrosine Kinase J. Biol. Chem., April 21, 2000; 275(17): 13142 - 13148. [Abstract] [Full Text] [PDF] M. Horita, E. J. Andreu, A. Benito, C. Arbona, C. Sanz, I. Benet, F. Prosper, and J. L. Fernandez-Luna Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5-Dependent Expression of Bcl-XL J. Exp. Med., March 20, 2000; 191(6): 977 - 984. [Abstract] [Full Text] [PDF] C. Sillaber, F. Gesbert, D. A. Frank, M. Sattler, and J. D. Griffin STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells Blood, March 15, 2000; 95(6): 2118 - 2125. [Abstract] [Full Text] [PDF] M. S. Neshat, A. B. Raitano, H.-G. Wang, J. C. Reed, and C. L. Sawyers The Survival Function of the Bcr-Abl Oncogene Is Mediated by Bad-Dependent and -Independent Pathways: Roles for Phosphatidylinositol 3-Kinase and Raf Mol. Cell. Biol., February 15, 2000; 20(4): 1179 - 1186. [Abstract] [Full Text] P. A. Svingen, A. Tefferi, T. J. Kottke, G. Kaur, V. L. Narayanan, E. A. Sausville, and S. H. Kaufmann Effects of the bcr/abl Kinase Inhibitors AG957 and NSC 680410 on Chronic Myelogenous Leukemia Cells in Vitro Clin. Cancer Res., January 1, 2000; 6(1): 237 - 249. [Abstract] [Full Text] K. L. Berg, K. A. Siminovitch, and E. R. Stanley SHP-1 Regulation of p62DOK Tyrosine Phosphorylation in Macrophages J. Biol. Chem., December 10, 1999; 274(50): 35855 - 35865. [Abstract] [Full Text] [PDF] M. Sattler, S. Verma, C. H. Byrne, G. Shrikhande, T. Winkler, P. A. Algate, L. R. Rohrschneider, and J. D. Griffin BCR/ABL Directly Inhibits Expression of SHIP, an SH2-Containing Polyinositol-5-Phosphatase Involved in the Regulation of Hematopoiesis Mol. Cell. Biol., November 1, 1999; 19(11): 7473 - 7480. [Abstract] [Full Text] [PDF] X. Jiang, A. Lopez, T. Holyoake, A. Eaves, and C. Eaves Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia PNAS, October 26, 1999; 96(22): 12804 - 12809. [Abstract] [Full Text] [PDF] F. Pane, I. Mostarda, C. Selleri, R. Salzano, A. M. Raiola, L. Luciano, G. Saglio, B. Rotoli, and F. Salvatore BCR/ABL mRNA and the P210BCR/ABL Protein Are Downmodulated by Interferon-alpha in Chronic Myeloid Leukemia Patients Blood, October 1, 1999; 94(7): 2200 - 2207. [Abstract] [Full Text] [PDF] T. Holyoake, X. Jiang, C. Eaves, and A. Eaves Isolation of a Highly Quiescent Subpopulation of Primitive Leukemic Cells in Chronic Myeloid Leukemia Blood, September 15, 1999; 94(6): 2056 - 2064. [Abstract] [Full Text] [PDF] L. Gabriele, J. Phung, J. Fukumoto, D. Segal, I-M. Wang, P. Giannakakou, N. A. Giese, K. Ozato, and H. C. Morse III Regulation of Apoptosis in Myeloid Cells by Interferon Consensus Sequence-Binding Protein J. Exp. Med., August 2, 1999; 190(3): 411 - 422. [Abstract] [Full Text] [PDF] R. G. Wickremasinghe and A. V. Hoffbrand Biochemical and Genetic Control of Apoptosis: Relevance to Normal Hematopoiesis and Hematological Malignancies Blood, June 1, 1999; 93(11): 3587 - 3600. [Full Text] [PDF] Q. P. Dou, T. F. McGuire, Y. Peng, and B. An Proteasome Inhibition Leads to Significant Reduction of Bcr-Abl Expression and Subsequent Induction of Apoptosis in K562 Human Chronic Myelogenous Leukemia Cells J. Pharmacol. Exp. Ther., May 1, 1999; 289(2): 781 - 790. [Abstract] [Full Text] M. Nieborowska-Skorska, M. A. Wasik, A. Slupianek, P. Salomoni, T. Kitamura, B. Calabretta, and T. Skorski Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis J. Exp. Med., April 19, 1999; 189(8): 1229 - 1242. [Abstract] [Full Text] [PDF] F. Vinante, A. Rigo, E. Papini, M. A. Cassatella, and G. Pizzolo Heparin-Binding Epidermal Growth Factor-Like Growth Factor/Diphtheria Toxin Receptor Expression by Acute Myeloid Leukemia Cells Blood, March 1, 1999; 93(5): 1715 - 1723. [Abstract] [Full Text] [PDF] L. M. Martins, T. J. Kottke, S. H. Kaufmann, and W. C. Earnshaw Phosphorylated Forms of Activated Caspases Are Present in Cytosol From HL-60 Cells During Etoposide-Induced Apoptosis Blood, November 1, 1998; 92(9): 3042 - 3049. [Abstract] [Full Text] [PDF] S. Moore, D. N. Haylock, J.-P. Levesque, L. A. McDiarmid, L. M. Samels, L. B. To, P. J. Simmons, and T. P. Hughes Stem Cell Factor as a Single Agent Induces Selective Proliferation of the Philadelphia Chromosome Positive Fraction of Chronic Myeloid Leukemia CD34+ Cells Blood, October 1, 1998; 92(7): 2461 - 2470. [Abstract] [Full Text] [PDF] T. Skorski, P. Wlodarski, L. Daheron, P. Salomoni, M. Nieborowska-Skorska, M. Majewski, M. Wasik, and B. Calabretta BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac PNAS, September 29, 1998; 95(20): 11858 - 11862. [Abstract] [Full Text] [PDF] F. Dazzi, D. Capelli, R. Hasserjian, F. Cotter, M. Corbo, A. Poletti, W. Chinswangwatanakul, J. M. Goldman, and M. Y. Gordon The Kinetics and Extent of Engraftment of Chronic Myelogenous Leukemia Cells in Non-Obese Diabetic/Severe Combined Immunodeficiency Mice Reflect the Phase of the Donor's Disease: An In Vivo Model of Chronic Myelogenous Leukemia Biology Blood, August 15, 1998; 92(4): 1390 - 1396. [Abstract] [Full Text] [PDF] A. M. Gewirtz, D. L. Sokol, and M. Z. Ratajczak Nucleic Acid Therapeutics: State of the Art and Future Prospects Blood, August 1, 1998; 92(3): 712 - 736. [Full Text] [PDF] C. Selleri, J. P. Maciejewski, F. Pane, L. Luciano, A. M. Raiola, I. Mostarda, F. Salvatore, and B. Rotoli Fas-Mediated Modulation of Bcr/Abl in Chronic Myelogenous Leukemia Results in Differential Effects on Apoptosis Blood, August 1, 1998; 92(3): 981 - 989. [Abstract] [Full Text] [PDF] P. Salomoni, M. A. Wasik, R. F. Riedel, K. Reiss, J. K. Choi, T. Skorski, and B. Calabretta Expression of Constitutively Active Raf-1 in the Mitochondria Restores Antiapoptotic and Leukemogenic Potential of a Transformation-deficient BCR/ABL Mutant J. Exp. Med., June 15, 1998; 187(12): 1995 - 2007. [Abstract] [Full Text] [PDF] R. Bhatia and C. M. Verfaillie Inhibition of BCR-ABL Expression With Antisense Oligodeoxynucleotides Restores beta 1 Integrin-Mediated Adhesion and Proliferation Inhibition in Chronic Myelogenous Leukemia Hematopoietic Progenitors Blood, May 1, 1998; 91(9): 3414 - 3422. [Abstract] [Full Text] [PDF] L. Dubrez, B. Eymin, O. Sordet, N. Droin, A. G. Turhan, and E. Solary BCR-ABL Delays Apoptosis Upstream of Procaspase-3 Activation Blood, April 1, 1998; 91(7): 2415 - 2422. [Abstract] [Full Text] [PDF] K. Yanagisawa, H. Yamauchi, M. Kaneko, H. Kohno, H. Hasegawa, and S. Fujita Suppression of Cell Proliferation and the Expression of a bcr-abl Fusion Gene and Apoptotic Cell Death in a New Human Chronic Myelogenous Leukemia Cell Line, KT-1, by Interferon-alpha Blood, January 15, 1998; 91(2): 641 - 648. [Abstract] [Full Text] [PDF] D. Blickstein, A. Aviram, J. Luboshitz, M. Prokocimer, P. Stark, O. Bairey, J. Sulkes, and M. Shaklai BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients: Clinical Presentation Blood, October 1, 1997; 90(7): 2768 - 2771. [Abstract] [Full Text] [PDF] R. A. Brodsky, M. S. Vala, J. P. Barber, M. E. Medof, and R. J. Jones Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria PNAS, August 5, 1997; 94(16): 8756 - 8760. [Abstract] [Full Text] [PDF] S. Qin, Y. Minami, T. Kurosaki, and H. Yamamura Distinctive Functions of Syk and Lyn in Mediating Osmotic Stress- and Ultraviolet C Irradiation-induced Apoptosis in Chicken B Cells J. Biol. Chem., July 18, 1997; 272(29): 17994 - 17999. [Abstract] [Full Text] [PDF] A.L. Petzer, C.J. Eaves, M.J. Barnett, and A.C. Eaves Selective Expansion of Primitive Normal Hematopoietic Cells in Cytokine-Supplemented Cultures of Purified Cells From Patients With Chronic Myeloid Leukemia Blood, July 1, 1997; 90(1): 64 - 69. [Abstract] [Full Text] [PDF] J.L. Vaerman, P. Moureau, F. Deldime, P. Lewalle, C. Lammineur, F. Morschhauser, and P. Martiat Antisense Oligodeoxyribonucleotides Suppress Hematologic Cell Growth Through Stepwise Release of Deoxyribonucleotides Blood, July 1, 1997; 90(1): 331 - 339. [Abstract] [Full Text] [PDF] C. Selleri, T. Sato, L. Del Vecchio, L. Luciano, A. J. Barrett, B. Rotoli, N. S. Young, and J. P. Maciejewski Involvement of Fas-Mediated Apoptosis in the Inhibitory Effects of Interferon-alpha in Chronic Myelogenous Leukemia Blood, February 1, 1997; 89(3): 957 - 964. [Abstract] [Full Text] [PDF] A. J. McGahon, W. K. Nishioka, S. J. Martin, A. Mahboubi, T. G. Cotter, and D. R. Green Regulation of the Fas Apoptotic Cell Death Pathway by Abl J. Biol. Chem., September 22, 1995; 270(38): 22625 - 22631. [Abstract] [Full Text] [PDF] S. R. Lasky, K. Iwata, A. G. Rosmarin, D. G. Caprio, and A. L. Maizel Differential Regulation of JunD by Dihydroxycholecalciferol in Human Chronic Myelogenous Leukemia Cells J. Biol. Chem., August 25, 1995; 270(34): 19676 - 19679. [Abstract] [Full Text] [PDF] F. Gesbert, W. R. Sellers, S. Signoretti, M. Loda, and J. D. Griffin BCR/ABL Regulates Expression of the Cyclin-dependent Kinase Inhibitor p27Kip1 through the Phosphatidylinositol 3-Kinase/AKT Pathway J. Biol. Chem., December 8, 2000; 275(50): 39223 - 39230. [Abstract] [Full Text] [PDF] Y. Parada, L. Banerji, J. Glassford, N. C. Lea, M. Collado, C. Rivas, J. L. Lewis, M. Y. Gordon, N. S. B. Thomas, and E. W.-F. Lam BCR-ABL and Interleukin 3 Promote Haematopoietic Cell Proliferation and Survival through Modulation of Cyclin D2 and p27Kip1 Expression J. Biol. Chem., June 22, 2001; 276(26): 23572 - 23580. [Abstract] [Full Text] [PDF]

	Copyright © 1994 by American Society of Hematology         Online ISSN: 1528-0020