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Autocrine interleukin-1 beta regulates both proliferation and apoptosis in
EL4-6.1 thymoma cells
M Fratelli, V Gagliardini, G Galli, P Gnocchi, P Ghiara and P Ghezzi
Istituto di Richerche Farmacologiche Mario Negri, Milan, Italy.
We demonstrate here that EL4-6.1 cells, a mouse thymoma that expresses high
levels of membrane interleukin (IL)-1 receptors, produce IL-1 beta as an
autocrine regulatory factor. Endogenous IL-1 beta sustains both
proliferation and apoptosis: during the exponential phase, it mainly
promotes proliferation, while during the plateau phase of cell growth, it
induces death by apoptosis. Additionally, we show that exogenous IL- 1 beta
added to EL4-6.1 cells in lag phase induces apoptosis in a portion of the
cells and proliferation in the remaining cells. Therefore, IL-1 beta can
exert two completely opposite effects on a single cell type, depending on
the state of the target cell.
Volume 85,
Issue 12,
pp. 3532-3537,
06/15/1995
Copyright © 1995 by The American Society of Hematology
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