Inhibition of CD26 enzyme activity with pro-boropro stimulates rat
granulocyte/macrophage colony formation and thymocyte proliferation in
vitro
LA Bristol, W Bachovchin and L Takacs
Unit of Special Projects, National Institute on Alcohol and Alcohol Abuse,
National Institutes of Health, Rockville, MD, USA.
CD26 dipeptidyl peptidase (DPPIV) is involved in the regulation of
proliferation of some hematopoietic and T-lineage cells. Here, we show that
Pro-boropro a potent inhibitor of DPP activity has a costimulating effect
in hematopoietic colony assays for macrophage and, to a lesser extent, for
granulocyte colonies and has a stimulating effect in organ cultures of
immature thymocytes. Based on these and other evidences, we propose that
the mechanism by which CD26 regulates proliferation is associated with its
DPP activity.
Volume 85,
Issue 12,
pp. 3602-3609,
06/15/1995
Copyright © 1995 by The American Society of Hematology
