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A clinical analysis of two indolent lymphoma entities: mantle cell lymphoma
and marginal zone lymphoma (including the mucosa-associated lymphoid tissue
and monocytoid B-cell subcategories): a Southwest Oncology Group study
RI Fisher, S Dahlberg, BN Nathwani, PM Banks, TP Miller and TM Grogan
Loyola University Stritch School of Medicine, Maywood, IL.
The objectives of this study were (1) to determine the clinical
presentation and natural history associated with two newly recognized
pathologic entities termed mantle cell lymphoma (MCL) and marginal zone
lymphoma (MZL), including the mucosa-associated lymphoid tissue (MALT) and
monocytoid B-cell subcategories, and (2) to determine whether these
entities differ clinically from the other relatively indolent non-
Hodgkin's lymphomas with which they have been previously classified. We
reviewed the conventional pathology and clinical course of 376 patients who
had no prior therapy; had stage III/IV disease; were classified as Working
Formulation categories A, B, C, D, or E; and received cyclophosphamide,
doxorubicin, vincristine, prednisone (CHOP) on Southwest Oncology Group
(SWOG) studies no. 7204, 7426, or 7713. All slides were reviewed by the
three pathologists who reached a consensus diagnosis. Age, sex, performance
status, bone marrow and/or gastrointestinal involvement, failure-free
survival, and overall survival were compared among all the categories. We
found that (1) MCL and MZL each represent approximately 10% of stage III or
IV patients previously classified as Working Formulation categories A
through E and treated with CHOP on SWOG clinical trials; (2) the
failure-free survival and overall survival of patients with MZL is the same
as that of patients with Working Formulation categories A through E, but
the failure-free survival and overall survival of the monocytoid B-cell
patients were higher than that of the MALT lymphoma patients (P = .009 and
.007, respectively); and (3) the failure-free survival and overall survival
of patients with MCL is significantly worse than that of patients with
Working Formulation categories A through E (P = .0002 and .0001,
respectively). In conclusion, patients with advanced stage MALT lymphomas
may have a more aggressive course than previously recognized. Patients with
MCL do not have an indolent lymphoma and are candidates for innovative
therapy.
Volume 85,
Issue 4,
pp. 1075-1082,
02/15/1995
Copyright © 1995 by The American Society of Hematology
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113(19):
4604 - 4613.
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|
|
|
|
|
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P. Martin, A. Chadburn, P. Christos, K. Weil, R. R. Furman, J. Ruan, R. Elstrom, R. Niesvizky, S. Ely, M. DiLiberto, et al.
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27(8):
1209 - 1213.
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|
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|
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October 1, 2008;
112(7):
2687 - 2693.
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[Full Text]
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|
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|
|
|
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Ann. Onc.,
July 1, 2008;
19(7):
1327 - 1330.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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April 1, 2008;
14(7):
2154 - 2160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Straus
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September 1, 2007;
3(5):
281 - 282.
[Full Text]
[PDF]
|
|
|
|
|
|
|
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April 1, 2007;
13(7):
2226 - 2235.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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18(1):
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[Full Text]
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|
|
|
|
|
|
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January 1, 2007;
2007(1):
270 - 276.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. I. Fisher, S. H. Bernstein, B. S. Kahl, B. Djulbegovic, M. J. Robertson, S. de Vos, E. Epner, A. Krishnan, J. P. Leonard, S. Lonial, et al.
Multicenter Phase II Study of Bortezomib in Patients With Relapsed or Refractory Mantle Cell Lymphoma
J. Clin. Oncol.,
October 20, 2006;
24(30):
4867 - 4874.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Strauss, L. Maharaj, S. Hoare, P. W. Johnson, J. A. Radford, S. Vinnecombe, L. Millard, A. Rohatiner, A. Boral, E. Trehu, et al.
Bortezomib Therapy in Patients With Relapsed or Refractory Lymphoma: Potential Correlation of In Vitro Sensitivity and Tumor Necrosis Factor Alpha Response With Clinical Activity
J. Clin. Oncol.,
May 1, 2006;
24(13):
2105 - 2112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Nademanee, S. Forman, A. Molina, H. Fung, D. Smith, A. Dagis, C. Kwok, D. Yamauchi, A.-L. Anderson, P. Falk, et al.
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October 15, 2005;
106(8):
2896 - 2902.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Romaguera, L. Fayad, M. A. Rodriguez, K. R. Broglio, F. B. Hagemeister, B. Pro, P. McLaughlin, A. Younes, F. Samaniego, A. Goy, et al.
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|
|
|
|
|
|
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23(26):
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|
|
|
|
|
|
|
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April 1, 2005;
16(4):
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|
|
|
|
|
|
|
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February 1, 2005;
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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104(12):
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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September 1, 2004;
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510 - 514.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kohlhammer, C. Schwaenen, S. Wessendorf, K. Holzmann, H. A. Kestler, D. Kienle, T. F. E. Barth, P. Moller, G. Ott, J. Kalla, et al.
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Blood,
August 1, 2004;
104(3):
795 - 801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Mangel, H. A. Leitch, J. M. Connors, R. Buckstein, K. Imrie, D. Spaner, M. Crump, N. Pennell, A. Boudreau, and N. L. Berinstein
Intensive chemotherapy and autologous stem-cell transplantation plus rituximab is superior to conventional chemotherapy for newly diagnosed advanced stage mantle-cell lymphoma: a matched pair analysis
Ann. Onc.,
February 1, 2004;
15(2):
283 - 290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Corcione, N. Arduino, E. Ferretti, L. Raffaghello, S. Roncella, D. Rossi, F. Fedeli, L. Ottonello, L. Trentin, F. Dallegri, et al.
CCL19 and CXCL12 Trigger in Vitro Chemotaxis of Human Mantle Cell Lymphoma B Cells
Clin. Cancer Res.,
February 1, 2004;
10(3):
964 - 971.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. I. Fisher, T. P. Miller, and O. A. O'Connor
Diffuse Aggressive Lymphoma
Hematology,
January 1, 2004;
2004(1):
221 - 236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. F. Khouri, M.-S. Lee, R. M. Saliba, G. Jun, L. Fayad, A. Younes, B. Pro, S. Acholonu, P. McLaughlin, R. L. Katz, et al.
Nonablative Allogeneic Stem-Cell Transplantation for Advanced/Recurrent Mantle-Cell Lymphoma
J. Clin. Oncol.,
December 1, 2003;
21(23):
4407 - 4412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. W. Tsang, M. K. Gospodarowicz, M. Pintilie, W. Wells, D. C. Hodgson, A. Sun, M. Crump, and B. J. Patterson
Localized Mucosa-Associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy Has Excellent Clinical Outcome
J. Clin. Oncol.,
November 15, 2003;
21(22):
4157 - 4164.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Kouroukis, A. Belch, M. Crump, E. Eisenhauer, R. D. Gascoyne, R. Meyer, R. Lohmann, P. Lopez, J. Powers, R. Turner, et al.
Flavopiridol in Untreated or Relapsed Mantle-Cell Lymphoma: Results of a Phase II Study of the National Cancer Institute of Canada Clinical Trials Group
J. Clin. Oncol.,
May 1, 2003;
21(9):
1740 - 1745.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Klasa, R. M. Meyer, C. Shustik, C. A. Sawka, A. Smith, R. Guevin, A. Maksymiuk, M. Rubinger, M. Samosh, S. Laplante, et al.
Randomized Phase III Study of Fludarabine Phosphate Versus Cyclophosphamide, Vincristine, and Prednisone in Patients With Recurrent Low-Grade Non-Hodgkin's Lymphoma Previously Treated With an Alkylating Agent or Alkylator-Containing Regimen
J. Clin. Oncol.,
December 15, 2002;
20(24):
4649 - 4654.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Igarashi, Y. Kobayashi, M. Ogura, T. Kinoshita, T. Ohtsu, Y. Sasaki, Y. Morishima, T. Murate, M. Kasai, N. Uike, et al.
Factors affecting toxicity, response and progression-free survival in relapsed patients with indolent B-cell lymphoma and mantle cell lymphoma treated with rituximab: a Japanese phase II study
Ann. Onc.,
June 1, 2002;
13(6):
928 - 943.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. K. Gopal, J. G. Rajendran, S. H. Petersdorf, D. G. Maloney, J. F. Eary, B. L. Wood, T. A. Gooley, S. A. Bush, L. D. Durack, P. J. Martin, et al.
High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma
Blood,
May 1, 2002;
99(9):
3158 - 3162.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. M. Howard, J. G. Gribben, D. S. Neuberg, M. Grossbard, C. Poor, M. J. Janicek, and M. A. Shipp
Rituximab and CHOP Induction Therapy for Newly Diagnosed Mantle-Cell Lymphoma: Molecular Complete Responses Are Not Predictive of Progression-Free Survival
J. Clin. Oncol.,
March 1, 2002;
20(5):
1288 - 1294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Conconi, F. Bertoni, E. Pedrinis, T. Motta, E. Roggero, S. Luminari, C. Capella, M. Bonato, F. Cavalli, and E. Zucca
Nodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes
Blood,
August 1, 2001;
98(3):
781 - 786.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Cavalli, P. G. Isaacson, R. D. Gascoyne, and E. Zucca
MALT Lymphomas
Hematology,
January 1, 2001;
2001(1):
241 - 258.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Arber
Molecular Diagnostic Approach to Non-Hodgkin's Lymphoma
J. Mol. Diagn.,
November 1, 2000;
2(4):
178 - 190.
[Full Text]
|
|
|
|
|
|
|
E. Zucca, F. Bertoni, E. Roggero, and F. Cavalli
The gastric marginal zone B-cell lymphoma of MALT type
Blood,
July 15, 2000;
96(2):
410 - 419.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ferraro, V. F. Trastek, H. Adlakha, C. Deschamps, M. S. Allen, and P. C. Pairolero
Primary non-Hodgkin's lymphoma of the lung
Ann. Thorac. Surg.,
April 1, 2000;
69(4):
993 - 997.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Yatabe, R. Suzuki, K. Tobinai, Y. Matsuno, R. Ichinohasama, M. Okamoto, M. Yamaguchi, J.-i. Tamaru, N. Uike, Y. Hashimoto, et al.
Significance of cyclin D1 overexpression for the diagnosis of mantle cell lymphoma: a clinicopathologic comparison of cyclin D1-positive MCL and cyclin D1-negative MCL-like B-cell lymphoma
Blood,
April 1, 2000;
95(7):
2253 - 2261.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Berger, P. Felman, C. Thieblemont, T. Pradier, L. Baseggio, P.-A. Bryon, G. Salles, E. Callet-Bauchu, and B. Coiffier
Non-MALT marginal zone B-cell lymphomas: a description of clinical presentation and outcome in 124 patients
Blood,
March 15, 2000;
95(6):
1950 - 1956.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Chiarle, L. M. Budel, J. Skolnik, G. Frizzera, M. Chilosi, A. Corato, G. Pizzolo, J. Magidson, A. Montagnoli, M. Pagano, et al.
Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma
Blood,
January 15, 2000;
95(2):
619 - 626.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. N. Nathwani, J. R. Anderson, J. O. Armitage, F. Cavalli, J. Diebold, M. R. Drachenberg, N. L. Harris, K. A. MacLennan, H. K. Muller-Hermelink, F. A. Ullrich, et al.
Marginal Zone B-Cell Lymphoma: A Clinical Comparison of Nodal and Mucosa-Associated Lymphoid Tissue Types
J. Clin. Oncol.,
August 1, 1999;
17(8):
2486 - 2486.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Babb, R. M. Cruz, and B. Puligandla
Sinonasal Mucosa-Associated Lymphoid Tissue Lymphoma
Arch Otolaryngol Head Neck Surg,
May 1, 1999;
125(5):
585 - 588.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-Y. Li, F. Gaillard, A. Moreau, J.-L. Harousseau, C. Laboisse, N. Milpied, R. Bataille, and H. Avet-Loiseau
Detection of Translocation t(11;14)(q13;q32) in Mantle Cell Lymphoma by Fluorescence in Situ Hybridization
Am. J. Pathol.,
May 1, 1999;
154(5):
1449 - 1452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. S. Andersen, J. W. Donovan, J. S. Borus, C. M. Poor, D. Neuberg, J. C. Aster, L. M. Nadler, A. S. Freedman, and J. G. Gribben
Failure of Immunologic Purging in Mantle Cell Lymphoma Assessed by Polymerase Chain Reaction Detection of Minimal Residual Disease
Blood,
November 15, 1997;
90(10):
4212 - 4221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Jennings and K. A. Foon
Recent Advances in Flow Cytometry: Application to the Diagnosis of Hematologic Malignancy
Blood,
October 15, 1997;
90(8):
2863 - 2892.
[Full Text]
[PDF]
|
|
|
|
|
|
|
The Non-Hodgkin's Lymphoma Classification Project
A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma
Blood,
June 1, 1997;
89(11):
3909 - 3918.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Argatoff, J. M. Connors, R. J. Klasa, D. E. Horsman, and R. D. Gascoyne
Mantle Cell Lymphoma: A Clinicopathologic Study of 80 Cases
Blood,
March 15, 1997;
89(6):
2067 - 2078.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Ott, J. Kalla, M. M. Ott, B. Schryen, T. Katzenberger, J. G. Muller, and H. K. Muller-Hermelink
Blastoid Variants of Mantle Cell Lymphoma: Frequent bcl-1 Rearrangements at the Major Translocation Cluster Region and Tetraploid Chromosome Clones
Blood,
February 15, 1997;
89(4):
1421 - 1429.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
