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Enhanced production of B lymphocytes after castration
CA Wilson, SA Mrose and DW Thomas
Biogen, Inc, Cambridge, MA 02142.
Castration has long been recognized to stimulate thymic growth and augment
cellular immunity. We sought to determine whether castration affects B
lymphopoiesis by analyzing the phenotype of bone marrow and spleen cells
from animals postcastration. In this report, we show that the bone marrow
cells from castrated male mice show a sustained, twofold to threefold
increase in numbers of B220+/IgM- cells and of newly formed B220+/IgM+ B
cells. Most of the expanded B220+/IgM- cell population consisted of small,
HSAhi, CD43- cells characteristic of pre- B cells. The castrated animals
also showed increased numbers of splenic B cells, primarily consisting of
small IgM+, IgDlo, B220lo, HSAhi cells. Taken together, these results show
that castration causes dramatic, long-lived enhancement of B lymphopoiesis
in bone marrow and increased numbers of mature B cells in the periphery.
Volume 85,
Issue 6,
pp. 1535-1539,
03/15/1995
Copyright © 1995 by The American Society of Hematology
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