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The flt3 ligand supports proliferation of lymphohematopoietic progenitors
and early B-lymphoid progenitors
F Hirayama, SD Lyman, SC Clark and M Ogawa
Department of Medicine, Medical University of South Carolina, Charleston,
USA.
We have examined the effects of the murine ligand (FL) for the flt3/flk2
tyrosine kinase receptor on the proliferation of murine lymphohematopoietic
progenitors as well as committed myeloid and B-cell progenitors. In the
presence of erythropoietin, FL alone supported scant colony formation from
enriched marrow cells of normal mice. However, when it was combined with
interleukin-3 (IL-3), steel factor (SF), or IL-11, FL significantly
enhanced colony formation. When tested on enriched marrow cells from
5-fluorouracil (5-FU)-treated mice, FL neither enhanced IL-3-dependent
colony formation nor synergized with SF in support of colony formation.
However, FL synergized with IL-6, IL- 11, or granulocyte-colony stimulating
factor (G-CSF) in support of formation of various types of colonies,
including multilineage colonies. Approximately 30% of these colonies
yielded pre-B-cell colonies when replated in secondary cultures containing
SF and IL-7, indicating that 2-cytokine combinations, including FL and
IL-6, IL-11, or G-CSF can support the proliferation of primitive
lymphohematopoietic progenitors. FL, by itself and in synergy with IL-7 or
SF, supported the proliferation of B-cell progenitors. These results show
that FL has a wide range of activities in early hematopoiesis and B
lymphopoiesis.
Volume 85,
Issue 7,
pp. 1762-1768,
04/01/1995
Copyright © 1995 by The American Society of Hematology
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