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Elevated serum levels of soluble CD23 (sCD23) precede the appearance
ofacquired immunodeficiency syndrome--associated non-Hodgkin's lymphoma
S Yawetz, WG Cumberland, M van der Meyden and O Martinez-Maza
Department of Microbiology & Immunology, Jonsson Comprehensive Cancer
Center, UCLA School of Medicine 90095-1747, USA.
Human immunodeficiency virus (HIV) infection-associated B-cell
hyperstimulation, in particular, the chronic stimulation of B cells to
undergo isotype switching, may play an important role in the pathogenesis
of acquired immunodeficiency syndrome-associated lymphoma (AIDS lymphoma).
Isotype switching can be induced by various immune system factors,
including cytokines, cell-surface stimulatory molecule interactions, and
CD23. CD23 is a B-cell differentiation and activation marker expressed on
mature B cells that is lost after isotype switching; soluble CD23 (sCD23)
also is a B-cell-stimulatory factor. Because sCD23 is associated with Ig
isotype switching, and because an enhancement of isotype switching may
contribute to the genesis of AIDS lymphoma, we examined serum sCD23 levels
in a retrospective study of HIV-seropositive subjects who had gone on to
develop lymphomas. Subjects were participants in the Multicenter AIDS
Cohort Study at UCLA, a study of the natural history of AIDS. Greatly
elevated sCD23 serum levels were seen in subjects who developed AIDS
lymphoma, when compared with others with AIDS (without lymphoma), or to
HIV- seronegative or HIV-seropositive subjects who did not have AIDS.
Because the induction of IgE has been tied to the activity of CD23, serum
IgE levels were also examined in this study, and found to be significantly
elevated in those who developed AIDS lymphoma. These findings suggests that
serum sCD23 levels potentially may serve as a clinical tool for early
detection of lymphomas in people who have HIV infection. Also, these
observations provide clues on possible pathogenetic mechanisms that result
in lymphomagenesis in the context of HIV infection and AIDS.
Volume 85,
Issue 7,
pp. 1843-1849,
04/01/1995
Copyright © 1995 by The American Society of Hematology
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