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Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same
level in infected cells of HTLV-1-associated myelopathy or tropical spastic
paraparesis patients as in asymptomatic carriers but at a lower level in
adult T-cell leukemia cells
Y Furukawa, M Osame, R Kubota, M Tara and M Yoshida
Department of Cellular and Molecular Biology, University of Tokyo, Japan.
Patients with human T-cell leukemia virus type-1 (HTLV-1)-associated
myelopathy (HAM/TSP) generally harbor a much greater population of HTLV-
1-infected T cells in peripheral blood mononuclear cells (PBMCs) than
asymptomatic carriers. These cells are not malignant but frequently
proliferate clonally. To investigate the possibility that higher expression
of the viral activator Tax induces preferential proliferation of infected
nonmalignant T cells in HAM/TSP patients, the expression of Tax mRNA in
fresh PBMCs was analyzed by reverse transcriptase-mediated polymerase chain
reaction. Total amount of Tax mRNA was higher in HAM/TSP patients than in
carriers, but the expression level was almost the same as that in
asymptomatic carriers when compared per infected cell. The expression
levels in adult T-cell leukemia patients were significantly lower than
those in HAM/TSP patients and asymptomatic carriers. These results indicate
that tax gene is not expressed at a continuously high level in HAM/TSP
patients who carry a high population of infected T cells, even in those
with clonally proliferated infected T cells.
Volume 85,
Issue 7,
pp. 1865-1870,
04/01/1995
Copyright © 1995 by The American Society of Hematology
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