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Trisomy 3 in low-grade B-cell lymphomas of mucosa-associated lymphoid
tissue
AC Wotherspoon, TM Finn and PG Isaacson
Department of Histopathology, University College London Medical School, UK.
Characteristic chromosomal aberrations have been associated with subtypes
of non-Hodgkin's lymphoma with distinct clinicopathologic features.
Low-grade B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) form
such a group and might be expected to be characterized by a specific
cytogenetic abnormality. Metaphase analyses of MALT lymphoma are rare due
to problems with fresh tissue collection and poor in vitro proliferation.
However, the small number of published series suggests that chromosome
trisomies, particularly trisomy 3, might be characteristic of these tumors.
The application of interphase cytogenetic techniques to routinely processed
material allows the examination of a large series of archival cases and is
particularly useful for the demonstration of chromosome trisomies. We have
used this technique to analyze 70 cases of low-grade MALT lymphoma from
various sites and found trisomy 3 in 60%. This finding compares with 16% in
low- grade nodal B-cell lymphoma and 27% in primary splenic lymphoma of
marginal zone type (splenic lymphoma with villous lymphocytes). These
results provide further evidence that low-grade MALT lymphomas from all
sites form a single pathologic entity distinct from nodal B-cell lymphomas.
Although MALT lymphoma and primary splenic lymphoma may arise from marginal
zone B cells, they are genetically distinct.
Volume 85,
Issue 8,
pp. 2000-2004,
04/15/1995
Copyright © 1995 by The American Society of Hematology
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