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Characterization of CD33 as a new member of the sialoadhesin family of
cellular interaction molecules
SD Freeman, S Kelm, EK Barber and PR Crocker
Molecular Haemopoiesis Laboratory, Imperial Cancer Research Fund (ICRF),
University of Oxford, John Radcliffe Hospital, Headington, UK.
CD33 is a member of the Ig superfamily that is restricted to cells of the
myelomonocytic lineage but whose functions and binding properties are
unknown. It shares sequence similarity with sialoadhesin, CD22, and the
myelin-associated glycoprotein, which constitute the Sialoadhesin family of
sialic acid-dependent cell adhesion molecules. In the present study, we
show that CD33 is a fourth member of this family. As a model for sialic
acid-dependent binding, human erythrocytes were derivatized with
N-acetylneuraminic acid (NeuAc) in different linkages. A recombinant
soluble form of CD33, Fc-CD33, bound red blood cells with a specificity
similar to that of sialoadhesin, preferring NeuAc alpha 2,3Gal in N- and
O-glycans over NeuAc alpha 2,6Gal in N-glycans. Fc- CD33 also bound
selectively to the myeloid cell lines HL-60 and U937. However, CD33 was
unable to mediate cell binding after transient expression in COS cells,
despite high levels of surface expression. Pretreatment of the
CD33-transfected cells with sialidase rendered them capable of mediating
sialic acid-dependent binding. These results show that CD33 can function as
a sialic acid-dependent cell adhesion molecule and that binding can be
modulated by endogenous sialoglycoconjugates when CD33 is expressed in a
plasma membrane.
Volume 85,
Issue 8,
pp. 2005-2012,
04/15/1995
Copyright © 1995 by The American Society of Hematology
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279(18):
18748 - 18758.
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278(33):
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|
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|
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|
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|
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|
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|
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|
|
|
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|
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|
|
|
|
|
|
|
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[Abstract]
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|
|
|
|
|
|
|
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J. Biol. Chem.,
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8633 - 8640.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Floyd, J. Ni, A. L. Cornish, Z. Zeng, D. Liu, K. C. Carter, J. Steel, and P. R. Crocker
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J. Biol. Chem.,
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Vitale, C. Romagnani, M. Falco, M. Ponte, M. Vitale, A. Moretta, A. Bacigalupo, L. Moretta, and M. C. Mingari
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December 21, 1999;
96(26):
15091 - 15096.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Nicoll, J. Ni, D. Liu, P. Klenerman, J. Munday, S. Dubock, M.-G. Mattei, and P. R. Crocker
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J. Biol. Chem.,
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Patel, E. C. M. B.-V. d. Linden, S. W. Altmann, K. Gish, S. Balasubramanian, J. C. Timans, D. Peterson, M. P. Bell, J. F. Bazan, A. Varki, et al.
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J. Biol. Chem.,
August 6, 1999;
274(32):
22729 - 22738.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. C. Taylor, C. D. Buckley, M. Douglas, A. J. Cody, D. L. Simmons, and S. D. Freeman
The Myeloid-specific Sialic Acid-binding Receptor, CD33, Associates with the Protein-tyrosine Phosphatases, SHP-1 and SHP-2
J. Biol. Chem.,
April 23, 1999;
274(17):
11505 - 11512.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Cornish, S. Freeman, G. Forbes, J. Ni, M. Zhang, M. Cepeda, R. Gentz, M. Augustus, K. C. Carter, and P. R. Crocker
Characterization of Siglec-5, a Novel Glycoprotein Expressed on Myeloid Cells Related to CD33
Blood,
September 15, 1998;
92(6):
2123 - 2132.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Razi and A. Varki
Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes
PNAS,
June 23, 1998;
95(13):
7469 - 7474.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. P. Skelton, C. Zeng, A. Nocks, and I. Stamenkovic
Glycosylation Provides Both Stimulatory and Inhibitory Effects on Cell Surface and Soluble CD44 Binding to Hyaluronan
J. Cell Biol.,
January 26, 1998;
140(2):
431 - 446.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. N.J. Hart
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
Blood,
November 1, 1997;
90(9):
3245 - 3287.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Gallart, D. Roelcke, M. Blay, A. Pereira, A. Martinez, O. Masso, O. Vinas, M. Cid, J. Esparza, R. Molina, et al.
Anti-Sia-lb (Anti-Gd) Cold Agglutinins Bind the Domain NeuNAcalpha 2-3Gal in Sialyl Lewisx, Sialyl Lewisa, and Related Carbohydrates on Nucleated Cells and in Soluble Cancer-Associated Mucins
Blood,
August 15, 1997;
90(4):
1576 - 1587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. E. Collins, M. Kiso, A. Hasegawa, M. B. Tropak, J. C. Roder, P. R. Crocker, and R. L. Schnaar
Binding Specificities of the Sialoadhesin Family of I-type Lectins. SIALIC ACID LINKAGE AND SUBSTRUCTURE REQUIREMENTS FOR BINDING OF MYELIN-ASSOCIATED GLYCOPROTEIN, SCHWANN CELL MYELIN PROTEIN, AND SIALOADHESIN
J. Biol. Chem.,
July 4, 1997;
272(27):
16889 - 16895.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. E. Collins, L. J.-S. Yang, G. Mukhopadhyay, M. T. Filbin, M. Kiso, A. Hasegawa, and R. L. Schnaar
Sialic Acid Specificity of Myelin-associated Glycoprotein Binding
J. Biol. Chem.,
January 10, 1997;
272(2):
1248 - 1255.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-X. Shi, R. Chammas, N. M. Varki, L. Powell, and A. Varki
Sialic Acid 9-O-Acetylation on Murine Erythroleukemia Cells Affects Complement Activation, Binding to I-type Lectins, and Tissue Homing
J. Biol. Chem.,
December 6, 1996;
271(49):
31526 - 31532.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Sgroi, A. Nocks, and I. Stamenkovic
A Single N-linked Glycosylation Site Is Implicated in the Regulation of Ligand Recognition by the I-type Lectins CD22 and CD33
J. Biol. Chem.,
August 2, 1996;
271(31):
18803 - 18809.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Vinson, P. A. van der Merwe, Sør. Kelm, A. May, E. Y. Jones, and P. R. Crocker
Characterization of the Sialic Acid-binding Site in Sialoadhesin by Site-directed Mutagenesis
J. Biol. Chem.,
April 19, 1996;
271(16):
9267 - 9272.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. van der Merwe, P. R. Crocker, M. Vinson, A. N. Barclay, R. Schauer, and Sør. Kelm
Localization of the Putative Sialic Acid-binding Site on the Immunoglobulin Superfamily Cell-surface Molecule CD22
J. Biol. Chem.,
April 19, 1996;
271(16):
9273 - 9280.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Nath, P. A. van der Merwe, Sør. Kelm, P. Bradfield, and P. R. Crocker
The Amino-terminal Immunoglobulin-like Domain of Sialoadhesin Contains the Sialic Acid Binding Site
J. Biol. Chem.,
November 3, 1995;
270(44):
26184 - 26191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Angata and A. Varki
Cloning, Characterization, and Phylogenetic Analysis of Siglec-9, a New Member of the CD33-related Group of Siglecs. EVIDENCE FOR CO-EVOLUTION WITH SIALIC ACID SYNTHESIS PATHWAYS
J. Biol. Chem.,
July 14, 2000;
275(29):
22127 - 22135.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Q. Zhang, G. Nicoll, C. Jones, and P. R. Crocker
Siglec-9, a Novel Sialic Acid Binding Member of the Immunoglobulin Superfamily Expressed Broadly on Human Blood Leukocytes
J. Biol. Chem.,
July 14, 2000;
275(29):
22121 - 22126.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Vinson, P. J. L. M. Strijbos, A. Rowles, L. Facci, S. E. Moore, D. L. Simmons, and F. S. Walsh
Myelin-associated Glycoprotein Interacts with Ganglioside GT1b. A MECHANISM FOR NEURITE OUTGROWTH INHIBITION
J. Biol. Chem.,
June 1, 2001;
276(23):
20280 - 20285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Li, W. Zhang, T. Wan, J. Zhang, T. Chen, Y. Yu, J. Wang, and X. Cao
Cloning and Characterization of Siglec-10, a Novel Sialic Acid Binding Member of the Ig Superfamily, from Human Dendritic Cells
J. Biol. Chem.,
July 20, 2001;
276(30):
28106 - 28112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Vitale, C. Romagnani, A. Puccetti, D. Olive, R. Costello, L. Chiossone, A. Pitto, A. Bacigalupo, L. Moretta, and M. C. Mingari
Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: Engagement of CD33 induces apoptosis of leukemic cells
PNAS,
May 8, 2001;
98(10):
5764 - 5769.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
