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Interleukin-12 enhances peripheral hematopoiesis in vivo
JD Jackson, Y Yan, MJ Brunda, LS Kelsey and JE Talmadge
Department of Pathology and Microbiology, University of Nebraska Medical
Center, Omaha 68198-3135, USA.
Interleukin 12(IL-12) is a cytokine that supports the proliferation and
activation of cytotoxic T lymphocytes and natural killer (NK) cells. Recent
evidence has suggested that IL-12 also has hematopoietic activities in
vitro. We report studies that show that IL-12 has significant in vivo
hematopoietic stimulating activity that includes enhancement of peripheral
(splenic) hematopoiesis and mobilization of hematopoietic progenitor cells
to the peripheral circulation. A single injection of recombinant murine
IL-12 significantly reduced the number of bone marrow (BM) colony-forming
unit granulocyte-macrophage (CFU-GM) in a time-dependent manner, while
concomitantly stimulating high proliferative potential. In contrast,
splenic CFU-GM and HPP were increased in a time- and dose-dependent manner.
Chronic administration of IL-12 resulted in significant splenic hyperplasia
with increased progenitor cells, increased circulating progenitor cells,
and BM hypoplasia with decreased progenitor cells. These data show that
IL-12 has significant in vivo hematopoietic effects that include the
ability to mobilize progenitor cells to the peripheral circulation, which
may prove to be of significant benefit for peripheral blood stem cell
transplantation. Thus, IL-12 has potential to be an important agent for
clinical transplantation because of its hematopoietic mobilization and its
previously shown immune augmenting and therapeutic activities. This
combination of hematopoietic and immune functions is unique and not
achievable with currently used hematopoietic growth factors.
Volume 85,
Issue 9,
pp. 2371-2376,
05/01/1995
Copyright © 1995 by The American Society of Hematology
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