|
|
 Previous Article | Table of Contents | Next Article 
Lymphoma-associated translocation t(14;18) in blood B cells of normal
individuals
J Limpens, R Stad, C Vos, C de Vlaam, D de Jong, GJ van Ommen, E Schuuring and PM Kluin
Departments of Pathology and Human Genetics, University of Leiden, The
Netherlands.
Successive oncogenic steps are necessary to generate cancer. In many B-
cell lymphomas, chromosomal translocations are considered to be an early
oncogenic hit. We investigated whether the lymphoma-associated t(14;18)
involving the BCL2 oncogene can occur outside the context of malignancy. To
this end, we extensively screened blood cells from healthy blood donors by
a very sensitive seminested polymerase chain reaction (PCR) for breakpoint
junctions at JH1-5 on 14q32 and the major breakpoint region of BCL2 on
18q21. In each individual, mononuclear cells, granulocytes, flow-sorted B
cells, and T cells were separately tested in five to seven independently
performed PCRs (in total, 0.5 x 10(6) to 1.0 x 10(6) cells per fraction per
individual). Amplification products that hybridized with an internal BCL2
probe and a JH probe were sequenced. Six of nine individuals harbored
t(14;18) breakpoints. Translocations were restricted to B cells, with an
estimated frequency of 1 in 10(5) or less circulating B cells. In total, 23
of 51 experiments on B cells were positive in contrast to 1 of 48 on T
cells and 2 of 47 experiments on granulocytes. Consistent with the presence
of 4.7% to 13.0% B cells in the mononuclear cell fractions, only very few
(4 of 47) tests were positive in these fractions. Sequence analysis showed
that four of six individuals harbored two to five unrelated
t(14;18)-carrying B-cell clones. All breakpoints had a structure similar to
that in follicular lymphoma. We propose that B cells with the t(14;18)
translocation are regularly generated in normal individuals, but that only
very few cells with the translocation will acquire the additional oncogenic
hits necessary to establish the malignant phenotype.
Volume 85,
Issue 9,
pp. 2528-2536,
05/01/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
N. Ueffing, K. K. Singh, A. Christians, C. Thorns, A. C. Feller, F. Nagl, F. Fend, S. Heikaus, A. Marx, R. B. Zotz, et al.
A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein
Blood,
July 16, 2009;
114(3):
572 - 579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Agopian, J.-M. Navarro, A.-C. Gac, Y. Lecluse, M. Briand, P. Grenot, P. Gauduchon, P. Ruminy, P. Lebailly, B. Nadel, et al.
Agricultural pesticide exposure and the molecular connection to lymphomagenesis
J. Exp. Med.,
July 6, 2009;
206(7):
1473 - 1483.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. T. Howard, S. Dufresne, S. H. Swerdlow, and J. R. Cook
Follicular Lymphoma of the Spleen: Multiparameter Analysis of 16 Cases
Am J Clin Pathol,
May 1, 2009;
131(5):
656 - 662.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R B Ilgenfritz, K Kayasut, A Le Tourneau, O A Calendini, L Ouafi, C Marzac, J Diebold, F Devez, V Ducruit, P E Bouchet, et al.
Correlation between molecular and histopathological diagnoses of B cell lymphomas in bone marrow biopsy and aspirates
J. Clin. Pathol.,
April 1, 2009;
62(4):
357 - 360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Brassesco, A. P. Montaldi, D. E. Gras, M. L. Camparoto, N. M. Martinez-Rossi, C. A. Scrideli, L. G. Tone, and E. T. Sakamoto-Hojo
Cytogenetic and molecular analysis of MLL rearrangements in acute lymphoblastic leukaemia survivors
Mutagenesis,
March 1, 2009;
24(2):
153 - 160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.-J. J. Cheung, S. P. Shah, C. Steidl, N. Johnson, T. Relander, A. Telenius, B. Lai, K. P. Murphy, W. Lam, A. J. Al-Tourah, et al.
Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances
Blood,
January 1, 2009;
113(1):
137 - 148.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. d'Amore, E. Chan, J. Iqbal, H. Geng, K. Young, L. Xiao, M. M. Hess, W. G. Sanger, L. Smith, C. Wiuf, et al.
Clonal Evolution in t(14;18)-Positive Follicular Lymphoma, Evidence for Multiple Common Pathways, and Frequent Parallel Clonal Evolution
Clin. Cancer Res.,
November 15, 2008;
14(22):
7180 - 7187.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. R. Calvo, B. Dabir, A. Kovach, C. Devor, R. Bandle, A. Bond, J. H. Shih, and E. S. Jaffe
IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma
Blood,
November 1, 2008;
112(9):
3818 - 3826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ruminy, F. Jardin, J.-M. Picquenot, F. Parmentier, N. Contentin, G. Buchonnet, S. Tison, V. Rainville, H. Tilly, and C. Bastard
S{micro} mutation patterns suggest different progression pathways in follicular lymphoma: early direct or late from FL progenitor cells
Blood,
September 1, 2008;
112(5):
1951 - 1959.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-J. Goval, C. Thielen, C. Bourguignon, R. Greimers, E. Dejardin, Y. S. Choi, J. Boniver, and L. de Leval
The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP
Haematologica,
August 1, 2008;
93(8):
1169 - 1177.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Potter
Brief Historical Sketch of Chromosomal Translocations and Tumors
J Natl Cancer Inst Monographs,
July 1, 2008;
2008(39):
2 - 7.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Dolken, L. Dolken, C. Hirt, C. Fusch, C. S. Rabkin, and F. Schuler
Age-Dependent Prevalence and Frequency of Circulating t(14;18)-Positive Cells in the Peripheral Blood of Healthy Individuals
J Natl Cancer Inst Monographs,
July 1, 2008;
2008(39):
44 - 47.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. McHale, Q. Lan, C. Corso, G. Li, L. Zhang, R. Vermeulen, J. D. Curry, M. Shen, R. Turakulov, R. Higuchi, et al.
Chromosome Translocations in Workers Exposed to Benzene
J Natl Cancer Inst Monographs,
July 1, 2008;
2008(39):
74 - 77.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Anderlini and R. E. Champlin
Biologic and molecular effects of granulocyte colony-stimulating factor in healthy individuals: recent findings and current challenges
Blood,
February 15, 2008;
111(4):
1767 - 1772.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Radcliffe, J. N. Arnold, D. M. Suter, M. R. Wormald, D. J. Harvey, L. Royle, Y. Mimura, Y. Kimura, R. B. Sim, S. Inoges, et al.
Human Follicular Lymphoma Cells Contain Oligomannose Glycans in the Antigen-binding Site of the B-cell Receptor
J. Biol. Chem.,
March 9, 2007;
282(10):
7405 - 7415.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Roulland, J.-M. Navarro, P. Grenot, M. Milili, J. Agopian, B. Montpellier, P. Gauduchon, P. Lebailly, C. Schiff, and B. Nadel
Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
J. Exp. Med.,
October 30, 2006;
203(11):
2425 - 2431.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. de Jong
Molecular Pathogenesis of Follicular Lymphoma: A Cross Talk of Genetic and Immunologic Factors
J. Clin. Oncol.,
September 10, 2005;
23(26):
6358 - 6363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bowman, D. Jones, L. J. Medeiros, and R. Luthra
Quantitative PCR Detection of t(14;18) bcl-2/JH Fusion Sequences in Follicular Lymphoma Patients: Comparison of Peripheral Blood and Bone Marrow Aspirate Samples
J. Mol. Diagn.,
November 1, 2004;
6(4):
396 - 400.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Brugger, J. Hirsch, F. Grunebach, R. Repp, P. Brossart, W. Vogel, H.-G. Kopp, M. G. Manz, M. Bitzer, G. Schlimok, et al.
Rituximab consolidation after high-dose chemotherapy and autologous blood stem cell transplantation in follicular and mantle cell lymphoma: a prospective, multicenter phase II study
Ann. Onc.,
November 1, 2004;
15(11):
1691 - 1698.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Vanasse, R. K. Winn, S. Rodov, A. W. Zieske, J. T. Li, J. C. Tupper, J. Tang, E. W. Raines, M. A. Peters, K. Y. Yeung, et al.
Bcl-2 Overexpression Leads to Increases in Suppressor of Cytokine Signaling-3 Expression in B Cells and De novo Follicular Lymphoma
Mol. Cancer Res.,
November 1, 2004;
2(11):
620 - 631.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. H. Sasso, M. Martinez, S. L. Yarfitz, P. Ghillani, L. Musset, J.-C. Piette, and P. Cacoub
Frequent Joining of Bcl-2 to a JH6 Gene in Hepatitis C Virus-Associated t(14;18)
J. Immunol.,
September 1, 2004;
173(5):
3549 - 3556.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Egle, A. W. Harris, M. L. Bath, L. O'Reilly, and S. Cory
VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia
Blood,
March 15, 2004;
103(6):
2276 - 2283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. L. Barrans, P. A.S. Evans, S. J.M. O'Connor, R. G. Owen, G. J. Morgan, and A. S. Jack
The Detection of t(14;18) in Archival Lymph Nodes: Development of a Fluorescence in Situ Hybridization (FISH)-Based Method and Evaluation by Comparison with Polymerase Chain Reaction
J. Mol. Diagn.,
August 1, 2003;
5(3):
168 - 175.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Fernandez-Ruiz, M. Cabrerizo, M. Ortega, C. Blas, P. Llamas, M. Santos-Roncero, S. Nieto, A. Acevedo, G. Perez, C. Nicolas, et al.
High Molecular Response Rate and Clinical Correlation in Patients with Follicular Lymphoma Treated with Cyclophosphamide-Vincristine-Prednisone plus Interferon {alpha} 2b
Clin. Cancer Res.,
July 1, 2003;
9(7):
2497 - 2503.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ladetto, D. Drandi, M. Compagno, M. Astolfi, F. Volpato, C. Voena, A. Novarino, B. Pollio, A. Addeo, I. Ricca, et al.
PCR-Detectable Nonneoplastic Bcl-2/IgH Rearrangements Are Common in Normal Subjects and Cancer Patients at Diagnosis but Rare in Subjects Treated With Chemotherapy
J. Clin. Oncol.,
April 1, 2003;
21(7):
1398 - 1403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Sanchez-Beato, A. Sanchez-Aguilera, and M. A. Piris
Cell cycle deregulation in B-cell lymphomas
Blood,
February 15, 2003;
101(4):
1220 - 1235.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Braziel, M. A. Shipp, A. L. Feldman, V. Espina, M. Winters, E. S. Jaffe, E. F. Petricoin III, and L. A. Liotta
Molecular Diagnostics
Hematology,
January 1, 2003;
2003(1):
279 - 293.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Zignego, C. Ferri, F. Giannelli, C. Giannini, P. Caini, M. Monti, M. E. Marrocchi, E. Di Pietro, G. La Villa, G. Laffi, et al.
Prevalence of bcl-2 Rearrangement in Patients with Hepatitis C Virus-Related Mixed Cryoglobulinemia with or without B-Cell Lymphomas
Ann Intern Med,
October 1, 2002;
137(7):
571 - 580.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Rawstron, M. R. Yuille, J. Fuller, M. Cullen, B. Kennedy, S. J. Richards, A. S. Jack, E. Matutes, D. Catovsky, P. Hillmen, et al.
Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion
Blood,
September 18, 2002;
100(7):
2289 - 2290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Rawstron, M. J. Green, A. Kuzmicki, B. Kennedy, J. A. L. Fenton, P. A. S. Evans, S. J. M. O'Connor, S. J. Richards, G. J. Morgan, A. S. Jack, et al.
Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts
Blood,
June 28, 2002;
100(2):
635 - 639.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Biagi and J. F. Seymour
Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation
Blood,
May 29, 2002;
99(12):
4265 - 4275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Cong, M. Raffeld, J. Teruya-Feldstein, L. Sorbara, S. Pittaluga, and E. S. Jaffe
In situ localization of follicular lymphoma: description and analysis by laser capture microdissection
Blood,
May 1, 2002;
99(9):
3376 - 3382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Z. Huang, W. G. Sanger, T. C. Greiner, L. M. Staudt, D. D. Weisenburger, D. L. Pickering, J. C. Lynch, J. O. Armitage, R. A. Warnke, A. A. Alizadeh, et al.
The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile
Blood,
April 1, 2002;
99(7):
2285 - 2290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Aster and J. A. Longtine
Detection of BCL2 Rearrangements in Follicular Lymphoma
Am. J. Pathol.,
March 1, 2002;
160(3):
759 - 763.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rambaldi, M. Lazzari, C. Manzoni, E. Carlotti, L. Arcaini, M. Baccarani, T. Barbui, C. Bernasconi, G. Dastoli, G. Fuga, et al.
Monitoring of minimal residual disease after CHOP and rituximab in previously untreated patients with follicular lymphoma
Blood,
February 1, 2002;
99(3):
856 - 862.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Husson, E. G. Carideo, D. Neuberg, J. Schultze, O. Munoz, P. W. Marks, J. W. Donovan, A. C. Chillemi, P. O'Connell, and A. S. Freedman
Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays
Blood,
January 1, 2002;
99(1):
282 - 289.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Herrera, U. Rodriguez, E. Gebhart, and P. Ostrosky-Wegman
Increased translocation frequency of chromosomes 7, 11 and 14 in lymphocytes from patients with neurocysticercosis
Mutagenesis,
November 1, 2001;
16(6):
495 - 497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. P. W. Mandigers, J. P. P. Meijerink, E. J. B. M. Mensink, E. L. R. T. M. Tonnissen, K. M. Hebeda, M. J. J. T. Bogman, and J. M. M. Raemaekers
Lack of correlation between numbers of circulating t(14;18)-positive cells and response to first-line treatment in follicular lymphoma
Blood,
August 15, 2001;
98(4):
940 - 944.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yasukawa, S. Bando, G. Dolken, E. Sada, Y. Yakushijin, S. Fujita, and H. Makino
Low frequency of BCL-2/JH translocation in peripheral blood lymphocytes of healthy Japanese individuals
Blood,
July 15, 2001;
98(2):
486 - 488.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Zhou, N. B. Levy, H. Xie, L. Qian, C.-Y. G. Lee, R. D. Gascoyne, and R. W. Craig
MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes
Blood,
June 15, 2001;
97(12):
3902 - 3909.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Maes, V. Vanhentenrijk, I. Wlodarska, J. Cools, B. Peeters, P. Marynen, and C. De Wolf-Peeters
The NPM-ALK and the ATIC-ALK Fusion Genes Can Be Detected in Non-Neoplastic Cells
Am. J. Pathol.,
June 1, 2001;
158(6):
2185 - 2193.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Airoldi, R. Guglielmino, F. Ghiotto, A. Corcione, P. Facchetti, M. Truini, and V. Pistoia
Cytokine Gene Expression in Neoplastic B Cells from Human Mantle Cell, Follicular, and Marginal Zone Lymphomas and in Their Postulated Normal Counterparts
Cancer Res.,
February 1, 2001;
61(4):
1285 - 1290.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Eguchi-Ishimae, M. Eguchi, E. Ishii, S. Miyazaki, K. Ueda, N. Kamada, and S. Mizutani
Breakage and fusion of the TEL (ETV6) gene in immature B lymphocytes induced by apoptogenic signals
Blood,
February 1, 2001;
97(3):
737 - 743.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. Summers, L. K. Goff, A. G. Wilson, R. K. Gupta, T. A. Lister, and J. Fitzgibbon
Frequency of the Bcl-2/IgH Rearrangement in Normal Individuals: Implications for the Monitoring of Disease in Patients With Follicular Lymphoma
J. Clin. Oncol.,
January 15, 2001;
19(2):
420 - 424.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Arber
Molecular Diagnostic Approach to Non-Hodgkin's Lymphoma
J. Mol. Diagn.,
November 1, 2000;
2(4):
178 - 190.
[Full Text]
|
|
|
|
|
|
|
T. G. Willis and M. J. S. Dyer
The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies
Blood,
August 1, 2000;
96(3):
808 - 822.
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. M. Aarts, R. J. Bende, E. J. Steenbergen, P. M. Kluin, E. C. M. Ooms, S. T. Pals, and C. J. M. van Noesel
Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load
Blood,
May 1, 2000;
95(9):
2922 - 2929.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Corcione, L. Ottonello, G. Tortolina, P. Facchetti, I. Airoldi, R. Guglielmino, P. Dadati, M. Truini, S. Sozzani, F. Dallegri, et al.
Stromal Cell-Derived Factor-1 as a Chemoattractant for Follicular Center Lymphoma B Cells
J Natl Cancer Inst,
April 19, 2000;
92(8):
628 - 635.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Apostolidis, R. K. Gupta, D. Grenzelias, P. W. M. Johnson, V. I. Pappa, K. E. Summers, A. Salam, K. Adams, A. J. Norton, J. A. L. Amess, et al.
High-Dose Therapy With Autologous Bone Marrow Support as Consolidation of Remission in Follicular Lymphoma: Long-Term Clinical and Molecular Follow-Up
J. Clin. Oncol.,
February 1, 2000;
18(3):
527 - 527.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Macintyre, D. Willerford, and S. W. Morris
Non-Hodgkin's Lymphoma: Molecular Features of B Cell Lymphoma
Hematology,
January 1, 2000;
2000(1):
180 - 204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Hallas, M. Albitar, J. Letofsky, M. J. Keating, K. Huebner, and C. M. Croce
Loss of FHIT Expression in Acute Lymphoblastic Leukemia
Clin. Cancer Res.,
September 1, 1999;
5(9):
2409 - 2414.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lopez-Guillermo, F. Cabanillas, T. I. McDonnell, P. McLaughlin, T. Smith, W. Pugh, F. Hagemeister, M. A. Rodriguez, J. E. Romaguera, A. Younes, et al.
Correlation of Bcl-2 Rearrangement With Clinical Characteristics and Outcome in Indolent Follicular Lymphoma
Blood,
May 1, 1999;
93(9):
3081 - 3087.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. A. Hosler, R. O. Bash, X. Bai, V. Jain, and R. H. Scheuermann
Development and Validation of a Quantitative Polymerase Chain Reaction Assay to Evaluate Minimal Residual Disease for T-Cell Acute Lymphoblastic Leukemia and Follicular Lymphoma
Am. J. Pathol.,
April 1, 1999;
154(4):
1023 - 1035.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Bose, M. Deininger, J. Gora-Tybor, J. M. Goldman, and J. V. Melo
The Presence of Typical and Atypical BCR-ABL Fusion Genes in Leukocytes of Normal Individuals: Biologic Significance and Implications for the Assessment of Minimal Residual Disease
Blood,
November 1, 1998;
92(9):
3362 - 3367.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Schnittger, B. Wormann, W. Hiddemann, and F. Griesinger
Partial Tandem Duplications of the MLL Gene Are Detectable in Peripheral Blood and Bone Marrow of Nearly All Healthy Donors
Blood,
September 1, 1998;
92(5):
1728 - 1734.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. A. Davis, D. G. Maloney, D. K. Czerwinski, T.-M. Liles, and R. Levy
Anti-Idiotype Antibodies Can Induce Long-Term Complete Remissions in Non-Hodgkin's Lymphoma Without Eradicating the Malignant Clone
Blood,
August 15, 1998;
92(4):
1184 - 1190.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. M. Uckun, K. Herman-Hatten, M.-L. Crotty, M. G. Sensel, H. N. Sather, L. Tuel-Ahlgren, M. B. Sarquis, B. Bostrom, J. B. Nachman, P. G. Steinherz, et al.
Clinical Significance of MLL-AF4 Fusion Transcript Expression in the Absence of a Cytogenetically Detectable t(4;11)(q21;q23) Chromosomal Translocation
Blood,
August 1, 1998;
92(3):
810 - 821.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Beylot-Barry, A. Groppi, B. Vergier, K. Pulford, J.P. Merlio, and t. French Study Group of Cutaneous Lymphoma
Characterization of t(2;5) Reciprocal Transcripts and Genomic Breakpoints in CD30+ Cutaneous Lymphoproliferations
Blood,
June 15, 1998;
91(12):
4668 - 4676.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lopez-Guillermo, F. Cabanillas, P. McLaughlin, T. Smith, F. Hagemeister, M. A. Rodriguez, J. E. Romaguera, A. Younes, A. H. Sarris, H. A. Preti, et al.
The Clinical Significance of Molecular Response in Indolent Follicular Lymphomas
Blood,
April 15, 1998;
91(8):
2955 - 2960.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ghia, V. A. Boussiotis, J. L. Schultze, A. A. Cardoso, D. M. Dorfman, J. G. Gribben, A. S. Freedman, and L. M. Nadler
Unbalanced Expression of Bcl-2 Family Proteins in Follicular Lymphoma: Contribution of CD40 Signaling in Promoting Survival
Blood,
January 1, 1998;
91(1):
244 - 251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. M. Leonard, F. Hetu, L. Busque, M. Gyger, R. Belanger, C. Perreault, and D.-C. Roy
Lymphoma Cell Burden in Progenitor Cell Grafts Measured by Competitive Polymerase Chain Reaction: Less Than One Log Difference Between Bone Marrow and Peripheral Blood Sources
Blood,
January 1, 1998;
91(1):
331 - 339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Jennings and K. A. Foon
Recent Advances in Flow Cytometry: Application to the Diagnosis of Hematologic Malignancy
Blood,
October 15, 1997;
90(8):
2863 - 2892.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. T. Voso, S. Hohaus, M. Moos, and R. Haas
Lack of t(14; 18) Polymerase Chain Reaction-Positive Cells in Highly Purified CD34+ Cells and Their CD19 Subsets in Patients With Follicular Lymphoma
Blood,
May 15, 1997;
89(10):
3763 - 3768.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
