SEARCH:   Advanced

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cattoretti, G Articles by Dalla-Favera, R Search for Related Content PubMed PubMed Citation Articles by Cattoretti, G Articles by Dalla-Favera, R Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  BCL-6 protein is expressed in germinal-center B cells G Cattoretti, CC Chang, K Cechova, J Zhang, BH Ye, B Falini, DC Louie, K Offit, RS Chaganti and R Dalla-Favera Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA. Structural alterations of the 5' noncoding region of the BCL-6 gene have been found in 40% of diffuse large cell lymphoma (DLCL) and 5% to 10% of follicular lymphomas (FL), suggesting that deregulated BCL-6 expression may play a role in lymphomagenesis. Nucleotide sequencing of BCL-6 cDNA predicted a protein containing six zinc-finger domains, suggesting that it may function as a transcription factor. Using antisera raised against N- and C-terminal BCL-6 synthetic oligopeptides in immunoprecipitation, immunoblot, and immunocytochemical assays, this study identifies the BCL-6 gene product as a 95-kD nuclear protein. Western blot analysis of human tumor cell lines representative of various hematopoietic lineages/stages of differentiation showed that the BCL-6 protein is predominantly expressed in the B-cell lineage where it was found in mature B cells. Immunohistochemical analysis of normal human lymphoid tissues indicated that BCL-6 expression is topographically restricted to germinal centers including all centroblasts and centrocytes. The BCL-6 protein was also detectable in inter- and intra-follicular CD4+ T cells, but not in other follicular components including mantle-zone B cells, plasma cells, dendritic cells, and macrophages. Immunohistochemical analysis of DLCL and FL biopsy samples showed that the BCL-6 protein is detectable in these tumors independent of the presence of BCL-6 gene rearrangements. These results indicate that the expression of the BCL-6 gene is specifically regulated during B-cell differentiation and suggest a role for BCL-6 in germinal center development or function. Because DLCL derive from germinal-center B cells, deregulated BCL-6 expression may contribute to lymphomagenesis by preventing postgerminal center differentiation. Volume 86, Issue 1, pp. 45-53, 07/01/1995 Copyright © 1995 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S.-O. Yoon, X. Zhang, P. Berner, and Y. S. Choi IL-21 and IL-10 have redundant roles but differential capacities at different stages of plasma cell generation from human germinal center B cells J. Leukoc. Biol., December 1, 2009; 86(6): 1311 - 1318. [Abstract] [Full Text] [PDF] R. J. Johnston, A. C. Poholek, D. DiToro, I. Yusuf, D. Eto, B. Barnett, A. L. Dent, J. Craft, and S. Crotty Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation Science, August 21, 2009; 325(5943): 1006 - 1010. [Abstract] [Full Text] [PDF] P. Barros, P. Jordan, and P. Matos Rac1 Signaling Modulates BCL-6-Mediated Repression of Gene Transcription Mol. Cell. Biol., August 1, 2009; 29(15): 4156 - 4166. [Abstract] [Full Text] [PDF] M. Saito, U. Novak, E. Piovan, K. Basso, P. Sumazin, C. Schneider, M. Crespo, Q. Shen, G. Bhagat, A. Califano, et al. BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma PNAS, July 7, 2009; 106(27): 11294 - 11299. [Abstract] [Full Text] [PDF] M. Gururajan, A. Simmons, T. Dasu, B. T. Spear, C. Calulot, D. A. Robertson, D. L. Wiest, J. G. Monroe, and S. Bondada Early Growth Response Genes Regulate B Cell Development, Proliferation, and Immune Response J. Immunol., October 1, 2008; 181(7): 4590 - 4602. [Abstract] [Full Text] [PDF] H. Schmidlin, S. A. Diehl, M. Nagasawa, F. A. Scheeren, R. Schotte, C. H. Uittenbogaart, H. Spits, and B. Blom Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression Blood, September 1, 2008; 112(5): 1804 - 1812. [Abstract] [Full Text] [PDF] S. A. Diehl, H. Schmidlin, M. Nagasawa, S. D. van Haren, M. J. Kwakkenbos, E. Yasuda, T. Beaumont, F. A. Scheeren, and H. Spits STAT3-Mediated Up-Regulation of BLIMP1 Is Coordinated with BCL6 Down-Regulation to Control Human Plasma Cell Differentiation J. Immunol., April 1, 2008; 180(7): 4805 - 4815. [Abstract] [Full Text] [PDF] F. Mora-Lopez, E. Reales, J. A. Brieva, and A. Campos-Caro Human BSAP and BLIMP1 conform an autoregulatory feedback loop Blood, November 1, 2007; 110(9): 3150 - 3157. [Abstract] [Full Text] [PDF] S. Valsami, V. Pappa, D. Rontogianni, F. Kontsioti, E. Papageorgiou, J. Dervenoulas, T. Karmiris, S. Papageorgiou, N. Harhalakis, N. Xiros, et al. A clinicopathological study of B-cell differentiation markers and transcription factors in classical Hodgkin's lymphoma: a potential prognostic role of MUM1/IRF4 Haematologica, October 1, 2007; 92(10): 1343 - 1350. [Abstract] [Full Text] [PDF] C. Atayar, A. van den Berg, T. Blokzijl, M. Boot, R. D Gascoyne, L. Visser, and S. Poppema Hodgkin's lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments J. Clin. Pathol., October 1, 2007; 60(10): 1092 - 1097. [Abstract] [Full Text] [PDF] S. Parekh, J. M. Polo, R. Shaknovich, P. Juszczynski, P. Lev, S. M. Ranuncolo, Y. Yin, U. Klein, G. Cattoretti, R. D. Favera, et al. BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms Blood, September 15, 2007; 110(6): 2067 - 2074. [Abstract] [Full Text] [PDF] Y. Kinugasa, M. Hieda, M. Hori, and S. Higashiyama The Carboxyl-terminal Fragment of Pro-HB-EGF Reverses Bcl6-mediated Gene Repression J. Biol. Chem., May 18, 2007; 282(20): 14797 - 14806. [Abstract] [Full Text] [PDF] T. C. Kuo, A. L. Shaffer, J. Haddad Jr., Y. S. Choi, L. M. Staudt, and K. Calame Repression of BCL-6 is required for the formation of human memory B cells in vitro J. Exp. Med., April 16, 2007; 204(4): 819 - 830. [Abstract] [Full Text] [PDF] H. Ichii, A. Sakamoto, M. Arima, M. Hatano, Y. Kuroda, and T. Tokuhisa Bcl6 is essential for the generation of long-term memory CD4+ T cells Int. Immunol., April 1, 2007; 19(4): 427 - 433. [Abstract] [Full Text] [PDF] J. M. Polo, P. Juszczynski, S. Monti, L. Cerchietti, K. Ye, J. M. Greally, M. Shipp, and A. Melnick Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas PNAS, February 27, 2007; 104(9): 3207 - 3212. [Abstract] [Full Text] [PDF] A. Kotani, N. Kakazu, T. Tsuruyama, I.-m. Okazaki, M. Muramatsu, K. Kinoshita, H. Nagaoka, D. Yabe, and T. Honjo Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice PNAS, January 30, 2007; 104(5): 1616 - 1620. [Abstract] [Full Text] [PDF] Z. S. M. Rahman, B. Alabyev, and T. Manser Fc{gamma}RIIB Regulates Autoreactive Primary Antibody-Forming Cell, but Not Germinal Center B Cell, Activity J. Immunol., January 15, 2007; 178(2): 897 - 907. [Abstract] [Full Text] [PDF] A. Reiter Diagnosis and Treatment of Childhood Non-Hodgkin Lymphoma Hematology, January 1, 2007; 2007(1): 285 - 296. [Abstract] [Full Text] [PDF] G. Cattoretti, R. Shaknovich, P. M. Smith, H.-M. Jack, V. V. Murty, and B. Alobeid Stages of Germinal Center Transit Are Defined by B Cell Transcription Factor Coexpression and Relative Abundance J. Immunol., November 15, 2006; 177(10): 6930 - 6939. [Abstract] [Full Text] [PDF] E. Arguni, M. Arima, N. Tsuruoka, A. Sakamoto, M. Hatano, and T. Tokuhisa JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells Int. Immunol., July 1, 2006; 18(7): 1079 - 1089. [Abstract] [Full Text] [PDF] I. S. Lossos and D. Morgensztern Prognostic Biomarkers in Diffuse Large B-Cell Lymphoma J. Clin. Oncol., February 20, 2006; 24(6): 995 - 1007. [Abstract] [Full Text] [PDF] D. Bechtel, J. Kurth, C. Unkel, and R. Kuppers Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas Blood, December 15, 2005; 106(13): 4345 - 4350. [Abstract] [Full Text] [PDF] N. Taubenheim, M. von Hornung, A. Durandy, K. Warnatz, L. Corcoran, H.-H. Peter, and H. Eibel Defined Blocks in Terminal Plasma Cell Differentiation of Common Variable Immunodeficiency Patients J. Immunol., October 15, 2005; 175(8): 5498 - 5503. [Abstract] [Full Text] [PDF] I. S. Lossos Molecular Pathogenesis of Diffuse Large B-Cell Lymphoma J. Clin. Oncol., September 10, 2005; 23(26): 6351 - 6357. [Abstract] [Full Text] [PDF] Y. Ohkubo, M. Arima, E. Arguni, S. Okada, K. Yamashita, S. Asari, S. Obata, A. Sakamoto, M. Hatano, J. O-Wang, et al. A Role for c-fos/Activator Protein 1 in B Lymphocyte Terminal Differentiation J. Immunol., June 15, 2005; 174(12): 7703 - 7710. [Abstract] [Full Text] [PDF] F. J. Pixley, Y. Xiong, R. Y.-L. Yu, E. A. Sahai, E. R. Stanley, and B. H. Ye BCL6 suppresses RhoA activity to alter macrophage morphology and motility J. Cell Sci., May 1, 2005; 118(9): 1873 - 1883. [Abstract] [Full Text] [PDF] D. Zhu, C. F. Qi, H. C. Morse III, S. Janz, and F. K. Stevenson Deregulated expression of the Myc cellular oncogene drives development of mouse "Burkitt-like" lymphomas from naive B cells Blood, March 1, 2005; 105(5): 2135 - 2137. [Abstract] [Full Text] [PDF] R. Y.-L. Yu, X. Wang, F. J. Pixley, J. J. Yu, A. L. Dent, H. E. Broxmeyer, E. R. Stanley, and B. H. Ye BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production Blood, February 15, 2005; 105(4): 1777 - 1784. [Abstract] [Full Text] [PDF] J. S. Rice, J. Newman, C. Wang, D. J. Michael, and B. Diamond Receptor editing in peripheral B cell tolerance PNAS, February 1, 2005; 102(5): 1608 - 1613. [Abstract] [Full Text] [PDF] T. T. Batchelor, B. R. Buchbinder, and N. L. Harris Case 1-2005 - A 35-Year-Old Woman with Difficulty Walking, Headache, and Nausea N. Engl. J. Med., January 13, 2005; 352(2): 185 - 194. [Full Text] [PDF] K. Basso, U. Klein, H. Niu, G. A. Stolovitzky, Y. Tu, A. Califano, G. Cattoretti, and R. Dalla-Favera Tracking CD40 signaling during germinal center development Blood, December 15, 2004; 104(13): 4088 - 4096. [Abstract] [Full Text] [PDF] T. Katzenberger, G. Ott, T. Klein, J. Kalla, H. K. Muller-Hermelink, and M. M. Ott Cytogenetic Alterations Affecting BCL6 Are Predominantly Found in Follicular Lymphomas Grade 3B with a Diffuse Large B-Cell Component Am. J. Pathol., August 1, 2004; 165(2): 481 - 490. [Abstract] [Full Text] [PDF] C. Tunyaplin, A. L. Shaffer, C. D. Angelin-Duclos, X. Yu, L. M. Staudt, and K. L. Calame Direct Repression of prdm1 by Bcl-6 Inhibits Plasmacytic Differentiation J. Immunol., July 15, 2004; 173(2): 1158 - 1165. [Abstract] [Full Text] [PDF] T. Chtanova, S. G. Tangye, R. Newton, N. Frank, M. R. Hodge, M. S. Rolph, and C. R. Mackay T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells J. Immunol., July 1, 2004; 173(1): 68 - 78. [Abstract] [Full Text] [PDF] I. S. Lossos, D. K. Czerwinski, A. A. Alizadeh, M. A. Wechser, R. Tibshirani, D. Botstein, and R. Levy Prediction of Survival in Diffuse Large-B-Cell Lymphoma Based on the Expression of Six Genes N. Engl. J. Med., April 29, 2004; 350(18): 1828 - 1837. [Abstract] [Full Text] [PDF] N. Chevallier, C. M. Corcoran, C. Lennon, E. Hyjek, A. Chadburn, V. J. Bardwell, J. D. Licht, and A. Melnick ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein Blood, February 15, 2004; 103(4): 1454 - 1463. [Abstract] [Full Text] [PDF] C. P. Hans, D. D. Weisenburger, T. C. Greiner, R. D. Gascoyne, J. Delabie, G. Ott, H. K. Muller-Hermelink, E. Campo, R. M. Braziel, E. S. Jaffe, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray Blood, January 1, 2004; 103(1): 275 - 282. [Abstract] [Full Text] [PDF] B. Falini, E. Tiacci, A. Pucciarini, B. Bigerna, J. Kurth, G. Hatzivassiliou, S. Droetto, B. V. Galletti, M. Gambacorta, A. Orazi, et al. Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT) Blood, November 15, 2003; 102(10): 3684 - 3692. [Abstract] [Full Text] [PDF] D. Capello, M. Cerri, G. Muti, E. Berra, P. Oreste, C. Deambrogi, D. Rossi, G. Dotti, A. Conconi, M. Vigano, et al. Molecular histogenesis of posttransplantation lymphoproliferative disorders Blood, November 15, 2003; 102(10): 3775 - 3785. [Abstract] [Full Text] [PDF] Z. SM. Rahman, S. P. Rao, S. L. Kalled, and T. Manser Normal Induction but Attenuated Progression of Germinal Center Responses in BAFF and BAFF-R Signaling-Deficient Mice J. Exp. Med., October 20, 2003; 198(8): 1157 - 1169. [Abstract] [Full Text] [PDF] A. M. Ranger, J. Zha, H. Harada, S. R. Datta, N. N. Danial, A. P. Gilmore, J. L. Kutok, M. M. Le Beau, M. E. Greenberg, and S. J. Korsmeyer Bad-deficient mice develop diffuse large B cell lymphoma PNAS, August 5, 2003; 100(16): 9324 - 9329. [Abstract] [Full Text] [PDF] H. Niu, G. Cattoretti, and R. Dalla-Favera BCL6 Controls the Expression of the B7-1/CD80 Costimulatory Receptor in Germinal Center B Cells J. Exp. Med., July 21, 2003; 198(2): 211 - 221. [Abstract] [Full Text] [PDF] P. Tsapogas, T. Breslin, S. Bilke, A. Lagergren, R. Mansson, D. Liberg, C. Peterson, and M. Sigvardsson RNA analysis of B cell lines arrested at defined stages of differentiation allows for an approximation of gene expression patterns during B cell development J. Leukoc. Biol., July 1, 2003; 74(1): 102 - 110. [Abstract] [Full Text] [PDF] N. Takeda, M. Arima, N. Tsuruoka, S. Okada, M. Hatano, A. Sakamoto, Y. Kohno, and T. Tokuhisa Bcl6 Is a Transcriptional Repressor for the IL-18 Gene J. Immunol., July 1, 2003; 171(1): 426 - 431. [Abstract] [Full Text] [PDF] L. Pasqualucci, A. Migliazza, K. Basso, J. Houldsworth, R. S. K. Chaganti, and R. Dalla-Favera Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma Blood, April 15, 2003; 101(8): 2914 - 2923. [Abstract] [Full Text] [PDF] U. Klein, Y. Tu, G. A. Stolovitzky, J. L. Keller, J. Haddad Jr., V. Miljkovic, G. Cattoretti, A. Califano, and R. Dalla-Favera Transcriptional analysis of the B cell germinal center reaction PNAS, March 4, 2003; 100(5): 2639 - 2644. [Abstract] [Full Text] [PDF] J. Linderoth, M. Jerkeman, E. Cavallin-Stahl, S. Kvaloy, and E. Torlakovic Immunohistochemical Expression of CD23 and CD40 May Identify Prognostically Favorable Subgroups of Diffuse Large B-cell Lymphoma: A Nordic Lymphoma Group Study Clin. Cancer Res., February 1, 2003; 9(2): 722 - 728. [Abstract] [Full Text] [PDF] A. G. Bosga-Bouwer, G. W. van Imhoff, R. Boonstra, A. van der Veen, E. Haralambieva, A. van den Berg, B. de Jong, V. Krause, M. C. Palmer, R. Coupland, et al. Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive Blood, February 1, 2003; 101(3): 1149 - 1154. [Abstract] [Full Text] [PDF] I. Wlodarska, P. Nooyen, B. Maes, J. I. Martin-Subero, R. Siebert, P. Pauwels, C. De Wolf-Peeters, and A. Hagemeijer Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma Blood, January 15, 2003; 101(2): 706 - 710. [Abstract] [Full Text] [PDF] S. W. French, C. S. Malone, R. R. Shen, M. Renard, S. E. Henson, M. D. Miner, R. Wall, and M. A. Teitell Sp1 Transactivation of the TCL1 Oncogene J. Biol. Chem., January 3, 2003; 278(2): 948 - 955. [Abstract] [Full Text] [PDF] X. Wang, Z. Li, A. Naganuma, and B. H. Ye Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas PNAS, November 12, 2002; 99(23): 15018 - 15023. [Abstract] [Full Text] [PDF] F. H. Vasanwala, S. Kusam, L. M. Toney, and A. L. Dent Repression of AP-1 Function: A Mechanism for the Regulation of Blimp-1 Expression and B Lymphocyte Differentiation by the B Cell Lymphoma-6 Protooncogene J. Immunol., August 15, 2002; 169(4): 1922 - 1929. [Abstract] [Full Text] [PDF] M. P. Butler, S. Iida, D. Capello, D. Rossi, P. H. Rao, P. Nallasivam, D. C. Louie, S. Chaganti, T. Au, R. D. Gascoyne, et al. Alternative Translocation Breakpoint Cluster Region 5' to BCL-6 in B-cell Non-Hodgkin's Lymphoma Cancer Res., July 15, 2002; 62(14): 4089 - 4094. [Abstract] [Full Text] [PDF] M. Arima, H. Toyama, H. Ichii, S. Kojima, S. Okada, M. Hatano, G. Cheng, M. Kubo, T. Fukuda, and T. Tokuhisa A Putative Silencer Element in the IL-5 Gene Recognized by Bcl6 J. Immunol., July 15, 2002; 169(2): 829 - 836. [Abstract] [Full Text] [PDF] G. H. Underhill, H. A. Minges-Wols, J. L. Fornek, P. L. Witte, and G. S. Kansas IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules Blood, April 15, 2002; 99(8): 2905 - 2912. [Abstract] [Full Text] [PDF] A. Melnick, G. Carlile, K. F. Ahmad, C.-L. Kiang, C. Corcoran, V. Bardwell, G. G. Prive, and J. D. Licht Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors Mol. Cell. Biol., March 15, 2002; 22(6): 1804 - 1818. [Abstract] [Full Text] [PDF] R. B. Lorsbach, D. Shay-Seymore, J. Moore, P. M. Banks, R. P. Hasserjian, J. T. Sandlund, and F. G. Behm Clinicopathologic analysis of follicular lymphoma occurring in children Blood, March 15, 2002; 99(6): 1959 - 1964. [Abstract] [Full Text] [PDF] B. Falini and D. Y. Mason Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry Blood, January 15, 2002; 99(2): 409 - 426. [Abstract] [Full Text] [PDF] K. Kahnt, K. Matz-Rensing, P. Hofmann, C. Stahl-Hennig, and F.-J. Kaup SIV-associated Lymphomas in Rhesus Monkeys (Macaca mulatta) in Comparison with HIV-associated Lymphomas Vet. Pathol., January 1, 2002; 39(1): 42 - 55. [Abstract] [Full Text] [PDF] P. Starostik, J. Patzner, A. Greiner, S. Schwarz, J. Kalla, G. Ott, and H. K. Muller-Hermelink Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways Blood, January 1, 2002; 99(1): 3 - 9. [Abstract] [Full Text] [PDF] U. Klein, Y. Tu, G. A. Stolovitzky, M. Mattioli, G. Cattoretti, H. Husson, A. Freedman, G. Inghirami, L. Cro, L. Baldini, et al. Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells J. Exp. Med., December 3, 2001; 194(11): 1625 - 1638. [Abstract] [Full Text] [PDF] I. S. Lossos, C. D. Jones, R. Warnke, Y. Natkunam, H. Kaizer, J. L. Zehnder, R. Tibshirani, and R. Levy Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma Blood, August 15, 2001; 98(4): 945 - 951. [Abstract] [Full Text] [PDF] A. Carbone, A. Gloghini, L. M. Larocca, D. Capello, F. Pierconti, V. Canzonieri, U. Tirelli, R. Dalla-Favera, and G. Gaidano Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas Blood, February 1, 2001; 97(3): 744 - 751. [Abstract] [Full Text] [PDF] N. L. Harris, H. Stein, S. E. Coupland, M. Hummel, R. D. Favera, L. Pasqualucci, and W. C. Chan New Approaches to Lymphoma Diagnosis Hematology, January 1, 2001; 2001(1): 194 - 220. [Abstract] [Full Text] [PDF] E. Hyjek, A. Chadburn, Y. F. Liu, E. Cesarman, and D. M. Knowles BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus Blood, January 1, 2001; 97(1): 270 - 276. [Abstract] [Full Text] [PDF] O. Albagli, C. Lindon, D. Lantoine, S. Quief, E. Puvion, C. Pinset, and F. Puvion-Dutilleul DNA Replication Progresses on the Periphery of Nuclear Aggregates Formed by the BCL6 Transcription Factor Mol. Cell. Biol., November 15, 2000; 20(22): 8560 - 8570. [Abstract] [Full Text] C. Angelin-Duclos, G. Cattoretti, K.-I Lin, and K. Calame Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo J. Immunol., November 15, 2000; 165(10): 5462 - 5471. [Abstract] [Full Text] [PDF] L. Pasqualucci, A. Neri, L. Baldini, R. Dalla-Favera, and A. Migliazza BCL-6 Mutations Are Associated with Immunoglobulin Variable Heavy Chain Mutations in B-Cell Chronic Lymphocytic Leukemia Cancer Res., October 1, 2000; 60(20): 5644 - 5648. [Abstract] [Full Text] T. G. Willis and M. J. S. Dyer The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies Blood, August 1, 2000; 96(3): 808 - 822. [Full Text] [PDF] H. Zan, Z. Li, K. Yamaji, P. Dramitinos, A. Cerutti, and P. Casali B Cell Receptor Engagement and T Cell Contact Induce bcl-6 Somatic Hypermutation in Human B Cells: Identity with Ig Hypermutation J. Immunol., July 15, 2000; 165(2): 830 - 839. [Abstract] [Full Text] [PDF] K. D. Huynh, W. Fischle, E. Verdin, and V. J. Bardwell BCoR, a novel corepressor involved in BCL-6 repression Genes & Dev., July 15, 2000; 14(14): 1810 - 1823. [Abstract] [Full Text] S. S. Sahota, Z. Davis, T. J. Hamblin, and F. K. Stevenson Somatic mutation of bcl-6 genes can occur in the absence of VH mutations in chronic lymphocytic leukemia Blood, June 1, 2000; 95(11): 3534 - 3540. [Abstract] [Full Text] [PDF] B. Falini, M. Fizzotti, A. Pucciarini, B. Bigerna, T. Marafioti, M. Gambacorta, R. Pacini, C. Alunni, L. Natali-Tanci, B. Ugolini, et al. A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells Blood, March 15, 2000; 95(6): 2084 - 2092. [Abstract] [Full Text] [PDF] I. S. Lossos and R. Levy Mutation analysis of the 5' noncoding regulatory region of the BCL-6 gene in non-Hodgkin lymphoma: evidence for recurrent mutations and intraclonal heterogeneity Blood, February 15, 2000; 95(4): 1400 - 1405. [Abstract] [Full Text] [PDF] D. Capello, U. Vitolo, L. Pasqualucci, S. Quattrone, G. Migliaretti, L. Fassone, C. Ariatti, D. Vivenza, A. Gloghini, C. Pastore, et al. Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia Blood, January 15, 2000; 95(2): 651 - 659. [Abstract] [Full Text] [PDF] M. Montesinos-Rongen, R. Kuppers, D. Schluter, T. Spieker, D. Van Roost, C. Schaller, G. Reifenberger, O. D. Wiestler, and M. Deckert-Schluter Primary Central Nervous System Lymphomas Are Derived from Germinal-Center B Cells and Show a Preferential Usage of the V4-34 Gene Segment Am. J. Pathol., December 1, 1999; 155(6): 2077 - 2086. [Abstract] [Full Text] [PDF] M. B. Harris, C.-C. Chang, M. T. Berton, N. N. Danial, J. Zhang, D. Kuehner, B. H. Ye, M. Kvatyuk, P. P. Pandolfi, G. Cattoretti, et al. Transcriptional Repression of Stat6-Dependent Interleukin-4-Induced Genes by BCL-6: Specific Regulation of Ivarepsilon Transcription and Immunoglobulin E Switching Mol. Cell. Biol., October 1, 1999; 19(10): 7264 - 7275. [Abstract] [Full Text] [PDF] A. L. Dent, T. M. Doherty, W. E. Paul, A. Sher, and L. M. Staudt BCL-6-Deficient Mice Reveal an IL-4-Independent, STAT6-Dependent Pathway That Controls Susceptibility to Infection by Leishmania major J. Immunol., August 15, 1999; 163(4): 2098 - 2103. [Abstract] [Full Text] [PDF] T. Yoshida, T. Fukuda, M. Hatano, H. Koseki, S.-i. Okabe, K. Ishibashi, S. Kojima, M. Arima, I. Komuro, G. Ishii, et al. The role of Bcl6 in mature cardiac myocytes Cardiovasc Res, June 1, 1999; 42(3): 670 - 679. [Abstract] [Full Text] [PDF] A. Brauninger, R. Kuppers, T. Spieker, R. Siebert, J. G. Strickler, B. Schlegelberger, K. Rajewsky, and M.-L. Hansmann Molecular Analysis of Single B Cells From T-Cell-Rich B-Cell Lymphoma Shows the Derivation of the Tumor Cells From Mutating Germinal Center B Cells and Exemplifies Means by Which Immunoglobulin Genes Are Modified in Germinal Center B Cells Blood, April 15, 1999; 93(8): 2679 - 2687. [Abstract] [Full Text] [PDF] C. ANGELIN-DUCLOS, G. CATTORETTI, D.H. CHANG, K.-I. LIN, Y. LIN, J. YU, and K. CALAME Role of B-lymphocyte-induced Maturation Protein-1 in Terminal Differentiation of B Cells and Other Cell Lineages Cold Spring Harb Symp Quant Biol, January 1, 1999; 64(0): 61 - 70. [Abstract] [PDF] A. L. Dent, J. Hu-Li, W. E. Paul, and L. M. Staudt T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6 PNAS, November 10, 1998; 95(23): 13823 - 13828. [Abstract] [Full Text] [PDF] C.-W. Wong and M. L. Privalsky Components of the SMRT Corepressor Complex Exhibit Distinctive Interactions with the POZ Domain Oncoproteins PLZF, PLZF-RARalpha , and BCL-6 J. Biol. Chem., October 16, 1998; 273(42): 27695 - 27702. [Abstract] [Full Text] [PDF] A. Carbone, A. Gloghini, G. Gaidano, S. Franceschi, D. Capello, H. G. Drexler, B. Falini, and R. Dalla-Favera Expression Status of BCL-6 and Syndecan-1 Identifies Distinct Histogenetic Subtypes of Hodgkin's Disease Blood, October 1, 1998; 92(7): 2220 - 2228. [Abstract] [Full Text] [PDF] E. Cesarman, A. Chadburn, Y.-F. Liu, A. Migliazza, R. Dalla-Favera, and D. M. Knowles BCL-6 Gene Mutations in Posttransplantation Lymphoproliferative Disorders Predict Response to Therapy and Clinical Outcome Blood, October 1, 1998; 92(7): 2294 - 2302. [Abstract] [Full Text] [PDF] L. Pasqualucci, A. Migliazza, N. Fracchiolla, C. William, A. Neri, L. Baldini, R. S. K. Chaganti, U. Klein, R. Kuppers, K. Rajewsky, et al. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci PNAS, September 29, 1998; 95(20): 11816 - 11821. [Abstract] [Full Text] [PDF] L. M. Larocca, D. Capello, A. Rinelli, S. Nori, A. Antinori, A. Gloghini, A. Cingolani, A. Migliazza, G. Saglio, S. Cammilleri-Broet, et al. The Molecular and Phenotypic Profile of Primary Central Nervous System Lymphoma Identifies Distinct Categories of the Disease and Is Consistent With Histogenetic Derivation From Germinal Center-Related B Cells Blood, August 1, 1998; 92(3): 1011 - 1019. [Abstract] [Full Text] [PDF] S. Okabe, T. Fukuda, K. Ishibashi, S. Kojima, S. Okada, M. Hatano, M. Ebara, H. Saisho, and T. Tokuhisa BAZF, a Novel Bcl6 Homolog, Functions as a Transcriptional Repressor Mol. Cell. Biol., July 1, 1998; 18(7): 4235 - 4244. [Abstract] [Full Text] H. Niu, B. H. Ye, and R. Dalla-Favera Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor Genes & Dev., July 1, 1998; 12(13): 1953 - 1961. [Abstract] [Full Text] G. Gaidano, A. Carbone, and R. Dalla-Favera Genetic Basis of Acquired Immunodeficiency Syndrome-Related Lymphomagenesis J Natl Cancer Inst Monographs, April 1, 1998; 1998(23): 95 - 100. [Abstract] [Full Text] J. Golay, V. Broccoli, G. Lamorte, C. Bifulco, C. Parravicini, A. Pizzey, N. S. B. Thomas, D. Delia, P. Ferrauti, D. Vitolo, et al. The A-Myb Transcription Factor Is a Marker of Centroblasts In Vivo J. Immunol., March 15, 1998; 160(6): 2786 - 2793. [Abstract] [Full Text] [PDF] A. Carbone, G. Gaidano, A. Gloghini, L. M. Larocca, D. Capello, V. Canzonieri, A. Antinori, U. Tirelli, B. Falini, and R. Dalla-Favera Differential Expression of BCL-6, CD138/Syndecan-1, and Epstein-Barr Virus-Encoded Latent Membrane Protein-1 Identifies Distinct Histogenetic Subsets of Acquired Immunodeficiency Syndrome-Related Non-Hodgkin's Lymphomas Blood, February 1, 1998; 91(3): 747 - 755. [Abstract] [Full Text] [PDF] W. Chen, S. Iida, D. C. Louie, R. Dalla-Favera, and R.S.K. Chaganti Heterologous Promoters Fused to BCL6 by Chromosomal Translocations Affecting Band 3q27 Cause Its Deregulated Expression During B-Cell Differentiation Blood, January 15, 1998; 91(2): 603 - 607. [Abstract] [Full Text] [PDF] P. Dhordain, O. Albagli, R. J. Lin, S. Ansieau, S. Quief, A. Leutz, J.-P. Kerckaert, R. M. Evans, and D. Leprince Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein PNAS, September 30, 1997; 94(20): 10762 - 10767. [Abstract] [Full Text] [PDF] T. Fukuda, T. Yoshida, S. Okada, M. Hatano, T. Miki, K. Ishibashi, S. Okabe, H. Koseki, S. Hirosawa, M. Taniguchi, et al. Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation J. Exp. Med., August 4, 1997; 186(3): 439 - 448. [Abstract] [Full Text] [PDF] G. Gaidano, A. Carbone, C. Pastore, D. Capello, A. Migliazza, A. Gloghini, S. Roncella, M. Ferrarini, G. Saglio, and R. Dalla-Favera Frequent Mutation of the 5' Noncoding Region of the BCL-6 Gene in Acquired Immunodeficiency Syndrome-Related Non-Hodgkin's Lymphomas Blood, May 15, 1997; 89(10): 3755 - 3762. [Abstract] [Full Text] [PDF]

	Copyright © 1995 by American Society of Hematology         Online ISSN: 1528-0020