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Role of light chain variable region in myeloma with light chain deposition
disease: evidence from an experimental model
AA Khamlichi, A Rocca, G Touchard, P Aucouturier, JL Preud'homme and M Cogne
Laboratoire d'Immunologie et Genetique, CNRS URA 1172, IBMIG, Faculte des
Sciences, Poitiers, France.
Light chain deposition disease (LCDD) results from a propensity of some
human monoclonal L chains to form tissue deposits. We designed an
experimental model for in vivo expression of human kappa L chain sequences
in mice and compared a somatically mutated LCDD chain with a closely
related control kappa chain, both encoded by the unique V kappa IV gene.
Mice secreting the LCDD chain but not those producing the control chain
showed deposits with a distribution similar to that observed in patients.
These data show that discrete changes in V region sequences can play a
major role in tissue deposition of human L chains.
Volume 86,
Issue 10,
pp. 3655-3659,
11/15/1995
Copyright © 1995 by The American Society of Hematology
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